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Method and system for preparing lipid metabolism type obese gene individualized intervention drink

A technology of lipid metabolism and obesity gene, which is applied in the fields of biochemical equipment and methods, food preparation, determination/inspection of microorganisms, etc.

Inactive Publication Date: 2015-12-16
上海中优精准医疗科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current clinical treatment methods for obesity are mainly diet and exercise therapy, but there are non-individualized treatment methods such as "one size fits all" control of carbohydrate, fat and protein intake and blind use of weight loss drugs

Method used

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  • Method and system for preparing lipid metabolism type obese gene individualized intervention drink
  • Method and system for preparing lipid metabolism type obese gene individualized intervention drink
  • Method and system for preparing lipid metabolism type obese gene individualized intervention drink

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Example 1 Establishment of combined genotype risk level one

[0074] The polymorphic site detected in this example is: rs2230806 ( ABCA1 ), rs2241766( ADIPOQ ) and rs320 ( LPL ), label them as a, b, and c, respectively, and their subtype risks are shown in Table 8 below:

[0075] Table 8

[0076] genetic polymorphism genotype Risk (OR) a 1(AA) 1

[0077] The risk level calculated according to the single gene risk level listed in Table 8 is shown in Table 4 above.

Embodiment 2

[0078] Example 2 Establishment of combined genotype risk level II

[0079] The polymorphic site detected in this example is: rs2230806 ( ABCA1 ), rs2241766( ADIPOQ ), rs320( LPL ) and rs429358 ( APOE ), mark them as a, b, c, and d, respectively, and their subtype risks are shown in Table 9 below:

[0080] Table 9

[0081] genetic polymorphism genotype Risk (OR) a 1(AA) 1

2(AG) 1

3(GG) 4.12 b 1(GG) 3.85

2(GT) 1

3(TT) 1 c 1(GG) 1

2(GT) 1

3(TT) 3.22 d 1(CC) 2.69

2(CT) 2.69

3(TT) 1

[0082] The risk level calculated according to the single gene risk level listed in the above table is shown in Table 10 below:

[0083] Table 10

[0084]

Embodiment 3

[0085] Example 3 Individual gene detection one

[0086] The three polymorphic sites in Example 1 were used for individual gene detection.

[0087] Individual oral epithelial cell samples were collected, and the genomic DNA was extracted by silica gel adsorption. After verification by electrophoresis, fluorescence quantitative PCR was performed.

[0088] Individual samples were put into 3 reaction wells, and 3 sites were detected at the same time, namely rs2230806 ( ABCA1 ), rs2241766( ADIPOQ ), rs320( LPL ), in addition, according to the needs of the experiment, an NTC blank control hole without DNA template was added;

[0089] Reagents were added to each reaction well as a fluorescent quantitative PCR reaction system, with a total volume of 10 μL, that is, 2 μL of DNA template with a concentration of 20 ng / μL, 10× fluorescent quantitative PCR reaction buffer ABITaqman ? 1 μL of MGB, 25 mM dNTPs for DNA synthesis of four deoxynucleotide substrates 0.1 μL, 25 mM MgCl 2 ...

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Abstract

The invention discloses a method and system for preparing a lipid metabolism type obese gene individualized intervention drink. The method for preparing the lipid metabolism type obese gene individualized intervention drink comprises the four steps of establishment of linked gene type risk grades, detection of individual genes, determination of a drink formula according to the risk grade of a detecting result and making of the drink. The specific weight losing drink can be prepared according to the linked gene type of a fat individual, and a better weight losing effect is achieved. The linked gene type of the individual is obtained through a one-time detecting program based on the linked detecting technology; the preparation system of the individualized intervention drink is adopted, so that the integrated process from sample detecting to drink preparation is achieved. The prepared individualized intervention drink has good tastes, and is highly popular with the public.

Description

technical field [0001] The invention relates to an individualized intervention drink for obesity genes, in particular to a preparation method and system for an individualized intervention drink for lipid metabolism-type obesity genes. Background technique [0002] Obesity, as a disease, is seriously threatening human health. The World Health Organization Expert Committee proposes to use Body-Mass Index (BMI) as the standard for overweight or obesity, that is, a BMI between 25 and 28 is considered overweight, 28 to 32 is considered obese, and a BMI greater than 32 is considered very obese. Obesity is a chronic disease closely related to genetic factors and lifestyle. It can cause elevated blood lipids, which can easily lead to fatty liver, arterial vascular disease, heart disease, and diabetes. Obese children can also cause sexual dysfunction and lead to The morbidity and mortality of various diseases increase in adulthood. [0003] The current clinical treatment methods fo...

Claims

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Application Information

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IPC IPC(8): C12Q1/68A23L2/02A23L1/29A23L33/00
CPCC12Q1/6883A23L2/02C12Q1/6827C12Q2600/156
Inventor 傅咏南
Owner 上海中优精准医疗科技股份有限公司
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