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Application of micro RNA mimics in preparation of drug treating choroidal neovascularization

A new blood vessel and choroid technology, applied in the field of biomedicine, can solve the problems of limited drug control effect and complicated interactions

Inactive Publication Date: 2015-12-09
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology

Since the formation of new blood vessels is the result of the joint action of various cells and molecules, and the interactions between cells and molecules are intricate, the prevention and treatment effect of drugs developed for a single cell / factor is often limited

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  • Application of micro RNA mimics in preparation of drug treating choroidal neovascularization
  • Application of micro RNA mimics in preparation of drug treating choroidal neovascularization
  • Application of micro RNA mimics in preparation of drug treating choroidal neovascularization

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Embodiment Construction

[0018] Matrix metalloproteinases (matrixmetalloproteinases, MMPs) degrade extracellular matrix and endogenous vascular inhibitory factors during CNV formation, promote cell migration, new vessel sprouting, and tube formation, and at the same time facilitate the invasion of bone marrow derived cells (BMCs) In CNV, participate in neovascularization. The MMPs expressed by CNV in situ cells are limited, and BMCs are involved in the generation of CNV and are an important source of MMPs in CNV. The inventors found that miR188-5p regulates the expression of MMP-2 / -13. In this study, by constructing a CNV model of chimeric mice, we observed and explored whether BMCs involved in CNV generation were an important source of MMPs and whether MMP-2 / -13 expressed by BMCs was regulated by miR188-5p to affect the development of CNV. Further, the artificially synthesized microRNA mimic agomir was used to regulate the level of miR-188-5p in BMCs and inhibit the secretion of MMP2 / 13, thereby inh...

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Abstract

The invention provides application of micro RNA mimics in the preparation of a drug treating choroidal neovascularization (CNV). The inventor adjusts bone marrow derived cells MMP expression through micro RNA, utilizes the characteristic of chemotaxis of the bone marrow derived cells to CNV to realize high precision targeted drug delivery and sustained release drug delivery for a part of the CNV part, so as to inhibit the bone marrow derived cells from forming pathological new vessels together with in situ cells. The invention also provides application of micro RNA agomir in the preparation of a drug treating the choroidal neovascularization. The inventor simultaneously adjusts two types of MMP expressions of BMCS through the micro RNA agomir, so the invasion of the BMCS is inhibited to reduce CNV cells and factor sources, and the in situ cells are inhibited from migrating, and the CNV can be efficiently treated; besides, due to the characteristic of the BMCS only enriching at a local part of the CNV, a high precision targeted therapy can be realized at the part of the CNV.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of microRNAmimics in the preparation of drugs for treating choroidal neovascularization. Background technique [0002] Choroidal neovascularization (CNV) is a common lesion of more than 40 eye diseases, with a high incidence rate and a serious threat to visual function. The etiology of CNV is complex, and the pathogenesis is still unclear. Although there are many clinical treatment methods for CNV at present, there are problems such as poor efficacy, high recurrence rate, uncertain long-term safety and high price, which bring a heavy burden to the family and society. Research in this field has become a national standard. A major strategic need. Exploring the pathogenesis of CNV and actively looking for efficient targets to inhibit angiogenesis are the hope for fundamentally curing CNV-related diseases. Since the formation of new blood vessels is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K48/00A61K31/7105A61K31/7088A61P27/02
Inventor 侯慧媛高凡梁宏亮王雨生吕洋王海燕郭长梅
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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