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Correlation between long noncoding RNA (ribonucleic acid) H19 and drug resistance of cancers to platinum chemotherapeutics

A chemotherapy drug and non-coding technology, applied in the fields of biomedicine and pharmaceuticals, can solve problems such as complex mechanisms, achieve improved prognosis, increase 5-year survival rate, and reduce platinum drug resistance

Active Publication Date: 2015-12-09
ZHEJIANG UNIV
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  • Abstract
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Problems solved by technology

Therefore, the mechanism by which H19 participates in tumorigenesis and development may be more complex
In addition, so far, the involvement of H19 in ovarian cancer cisplatin resistance and the specific mechanism of action have not been reported.

Method used

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  • Correlation between long noncoding RNA (ribonucleic acid) H19 and drug resistance of cancers to platinum chemotherapeutics
  • Correlation between long noncoding RNA (ribonucleic acid) H19 and drug resistance of cancers to platinum chemotherapeutics
  • Correlation between long noncoding RNA (ribonucleic acid) H19 and drug resistance of cancers to platinum chemotherapeutics

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Embodiment Construction

[0029] Embodiments of the present invention will be described in detail below in conjunction with examples. Those skilled in the art should understand that the following examples are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention.

[0030] If no specific technique or condition is indicated in the examples, it shall be carried out according to the technique or condition described in the literature in this field or according to the product specification. The reagents or instruments used were not indicated by the manufacturer, and they were all conventional products that could be purchased in the market.

[0031] 1. Establishment and identification of drug-resistant human ovarian cancer cell lines

[0032] 1. Cell lines and their culture conditions

[0033] The human ovarian cancer cell line A2780 was purchased from China Center for Type Culture Collection (Address: Wuhan University Campus, No. 299, Bay...

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Abstract

The invention relates to correlation between long noncoding RNA (ribonucleic acid) H19 and drug resistance of cancers to platinum chemotherapeutics and relates to usages of medicaments, which are capable of reducing and / or inhibiting expression of the long noncoding RNA H19 in cancer cells, in preparation of medicines for treatment or prevention of cancers and medicines for reducing drug resistance of the cancers to the platinum chemotherapeutics. The invention further relates to usages of medicaments, which are capable of detecting expression of the long noncoding RNA H19, in preparation of detection kits, wherein the detection kits are used for diagnosis of carcinogenesis or predication of cancer relapse and used for predication, detection or diagnosis of drug resistance of cancer patients to the platinum chemotherapeutics. The invention further relates to pharmaceutical compositions comprising the medicaments. The cancers refer to cancers which can be treated with the platinum chemotherapeutics, and preferably, the cancers refer to ovarian cancers.

Description

technical field [0001] The invention belongs to the field of biomedicine and pharmacy, and specifically relates to the correlation between long non-coding RNAH19 and cancer platinum chemotherapy drug resistance. Background technique [0002] The mortality rate of ovarian cancer still ranks first in gynecological tumors. Although the treatment of ovarian cancer has been continuously improved, such as the expansion of surgical resection and the combination chemotherapy of paclitaxel and platinum drugs, the mortality rate is still high. It is reported that the five-year survival rate of stage III patients is only 29%. The reason is that in addition to the difficulty of early diagnosis, chemotherapy resistance is an important factor affecting the survival rate of ovarian cancer patients. Currently, platinum-based drugs are one of the first-choice drugs in the chemotherapy regimen for ovarian cancer. Although the effective rate of platinum-based combined chemotherapy for ovaria...

Claims

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Application Information

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IPC IPC(8): A61K48/00A61K38/46A61P35/00C12Q1/68C12N15/11
CPCA61K31/7088A61K48/00C12N15/113C12Q1/68
Inventor 华跃进郑智国徐虹
Owner ZHEJIANG UNIV
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