Degradable starch-based hemostatic material, preparation method therefor and applications

Abstract

The invention discloses a degradable starch-based hemostatic material, a preparation method therefor and applications. The preparation method comprises steps: firstly, raw materials processing is carried out, namely, starch is cleaned in water; secondly, crosslinking is carried out, namely, ultrapure water is added in starch, the temperature is risen to 30-70 DEG C, sodium chloride and a sodium trimetaphosphate solution are added, heat insulation is carried out for 10-60min, a reaction with stirring is carried out for 2-48h, the solution pH is adjusted, and crosslinking starch is obtained; thirdly, enzyme pore forming is carried out, namely, the crosslinking starch, calcium chloride and alpha-amylase are mixed and reacted for 2-24 h, the reaction temperature is 50-75 DEG C, and the degradable starch-based hemostatic material is obtained after cleaning. The degradable starch-based hemostatic material can be used for preparing a hemostatic material of body surfaces and tissues in bodies, and preparing a bleeding control material for excessive bleeding of parenchymal viscera in the bodies or movable parts or parts difficult for haemostasis. The degradable starch-based hemostatic material is advantaged by good biological compatibility, degradation in bodies, low cost, simple preparation, convenient production, no toxins and environmental protection.

Description

technical field [0001] The invention belongs to the field of tissue damage repairing medical devices, in particular to a degradable starch-based hemostatic material and its preparation method and application. Background technique [0002] Blood has the functions of nourishing and moistening various tissues and organs of the whole body, and is one of the basic substances that constitute the human body and maintain human life activities. Traumatic hemorrhage is a common occurrence in human life, and acute massive hemorrhage and deep hemorrhage of substantial organs caused by war, traffic accidents, natural disasters, etc. are the main causes of death, disability and teratogenicity after human injury. When the traumatic blood loss reaches more than 20% of the total blood volume, obvious shock symptoms appear; when it reaches 40% of the total blood volume, there is life-threatening. Effective hemostasis is a necessary guarantee for the safety of patients, and it is also an effe...

AI Technical Summary

Problems solved by technology

[0007] 1. It mainly relies on the absorption of water in the blood to stop bleeding, and has limited activation of the blood coagulation system;

[0008] 2. Poor retrogradation, easy to cause blood scab to fall off and destroy new tissue, directly affecting the hemostatic effect of the material;

[0009] 3. The cross-linking process adopted by some starch-based hemostatic materials is complicated, the cross-linking residue is large, and it has certain toxicity;

[0010] 4. The price of some imported materials is high, the packaging volume is small, and the application efficiency and cost ratio is not ideal;

[0011] 5. Hemostasis limited to small trauma and body surface (such as skin) in the body, and the hemostatic effect on deep substantive organs and active parts is not ideal;

[0012] 6. Lack of basis for drug loading and simultaneous application with hemostatic materials with other hemostatic mechanisms

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