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Use of cyclocarya paliurus extract in preparation of drug for preventing and treating non-alcoholic fatty liver disease

A non-alcoholic, extractive technology used in Cyclocarya paliurus extract in the pharmaceutical field

Inactive Publication Date: 2015-12-02
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the development of medicines and health products for Cyclocarya paliurus is mostly focused on its hypoglycemic effect, but whether Cyclocarya paliurus can effectively prevent and treat NAFLD has not yet been reported

Method used

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  • Use of cyclocarya paliurus extract in preparation of drug for preventing and treating non-alcoholic fatty liver disease
  • Use of cyclocarya paliurus extract in preparation of drug for preventing and treating non-alcoholic fatty liver disease
  • Use of cyclocarya paliurus extract in preparation of drug for preventing and treating non-alcoholic fatty liver disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: Preparation of Cyclocarya paliurus extract

[0014] 100g of dried leaves of Cyclocarya paliurus were extracted by refluxing 1L of pure water for 3 times, each time for 2h, the extracts were combined, filtered, and the solvent was recovered to obtain the aqueous extract of Cyclocarya paliurus.

Embodiment 2

[0015] Embodiment 2: Preparation of Cyclocarya paliurus extract

[0016] 250 g of dried leaves of Cyclocarya paliurus were extracted by refluxing with 2 L of 80% (volume / volume) ethanol for 3 times, each time for 2 hours, the extracts were combined, filtered, and evaporated to dryness to obtain the dry extract of the alcoholic extract of Cyclocarya paliurus. The extraction rate is about 20%.

Embodiment 3

[0017] Example 3 The improvement effect of Cyclocarya paliurus extract on NAFLD

[0018] 1. Materials

[0019] 1.1 Animals

[0020] Male SD rats, 180-220 g, SPF grade, were purchased from Shanghai Xipuer-Bikay Experimental Animal Co., Ltd., license number: SCXK(HU)2008-0016.

[0021] 1.2 Reagents

[0022] Triglyceride (TG), total cholesterol (TC), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) detection kits were purchased from Nanjing Jiancheng Bioengineering Institute.

[0023] 1.3 Medicinal materials

[0024] Take Cyclocarya paliurus water extract and alcohol extract extract powder, respectively dilute or dissolve in an appropriate amount of 0.5% sodium carboxymethylcellulose solution, and prepare a certain concentration of intragastric solution.

[0025] 2. Experimental method

[0026] Eighty healthy male SD rats were randomly divided into two groups according to body weight after adaptive feeding for one week. Ten of them were the normal contro...

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Abstract

The invention belongs to the field of pharmacy and relates to a use of cyclocarya paliurus extract in preparation of a drug for preventing and treating non-alcoholic fatty liver disease. The cyclocarya paliurus extract can effectively reduce a degree of high fat diet-caused rat liver lipid accumulation and a triglyceride level and improve hepatic tissue and lung functions so that it is shown that the cyclocarya paliurus can substantially improve non-alcoholic fatty liver disease and can be used for preparation of a drug and a health product for preventing and treating non-alcoholic fatty liver disease. The cyclocarya paliurus extract widens an application range of a cyclocarya paliurus preparation in the medicine field and provides a novel choice for preventing and treating non-alcoholic fatty liver disease.

Description

technical field [0001] The present invention relates to the new application of the extract of Cyclocarya paliurus, in particular to the new application of the extract of Cyclocarya paliurus in the field of pharmacy, to be precise the role of the extract of Cyclocarya paliurus in the preparation of medicines / health care products for preventing and treating non-alcoholic fatty liver use. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) is a clinical syndrome characterized by fatty degeneration and fat storage in hepatic parenchymal cells without a history of excessive alcohol consumption. It is by far the most common chronic liver disease. Its basic course includes simple fatty liver, steatohepatitis, fatty liver fibrosis, and may eventually develop into fatty liver cirrhosis and fatty liver cancer, which may lead to premature death. There are about 20-40% of NAFLD patients in the world, and the number is increasing and showing a trend of younger age. ...

Claims

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Application Information

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IPC IPC(8): A61K36/52A23L1/29A61P1/16A23L33/00
Inventor 殷志琦林孜吴正凤操兰洁
Owner CHINA PHARM UNIV
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