Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Novel skeleton alkaloid compound and extraction separation method thereof

A separation method and technology of alkaloids, applied in the direction of active ingredients of heterocyclic compounds, drug combination, organic chemistry, etc., can solve the problems of weak pharmacological activity and so on

Active Publication Date: 2015-11-25
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
View PDF4 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the separation and the pharmacological activity research of the new framework compound of purslane in the application have not been reported, and the chemical constituent majority that separates from purslane is known at present, and pharmacological activity is relatively weak, therefore, to purslane The development and isolation of new compounds in purslane is urgently needed

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel skeleton alkaloid compound and extraction separation method thereof
  • Novel skeleton alkaloid compound and extraction separation method thereof
  • Novel skeleton alkaloid compound and extraction separation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027] The invention provides a new skeleton alkaloid compound, the molecular formula is C 18 h 26 N 2 O. The chemical structural formula is as follows.

[0028]

[0029] The new skeleton alkaloid compound is named Oleracimine according to the structure, and Table 1 is the NMR data of the new skeleton alkaloid compound: 1 H-NMR with 13 C-NMR in CDCl 3 middle. Among them, "-" means that =NH is connected to C169.4 above.

[0030] Table 1: NMR data of new framework alkaloid compounds.

[0031] serial number δ C Types of δ H 2 46.8 CH 2 a: 1.47 d (J=13.5); b: 2.02 d (J=13.5) 3 38.9 C

4 50.6 C

5 52.3 CH 2 a: 2.28 d (J=15.3); b: 2.56 d (J=15.3) 6 65.7 C

7 206.2 C

8 121.3 C

9 141.0 C

10 143.5 C

11 110.7 C

12 169.4 C

- =NH 4.07 s 13 28.6 CH 3 1.34 s 14 32.5 CH 3 1.29 s 15 29.1 CH 3 1.30 s 16 27.4 CH 3 1...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Granularityaaaaaaaaaa
Login to View More

Abstract

The invention discloses a novel skeleton alkaloid compound. The novel skeleton alkaloid compound has a molecular formula of C18H26N2O, is named as Oleracimine and is shown in the chemical structural formula (I). The invention provides an extraction separation method of the novel skeleton alkaloid compound. The extraction separation method orderly comprises water decoction extraction, macroporous adsorption resin extraction, ethyl acetate extraction, silica gel column chromatography, ODS medium-pressure column treatment and Sephadex LH-20 treatment. The extraction separation method realizes simple and fast extraction separation of the novel skeleton alkaloid compound with a unique skeleton. The novel skeleton alkaloid compound has the effect of easing pain and can be used for preparation of pain easing drugs. The novel skeleton alkaloid compound is shown in the formula (I).

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to a new skeleton alkaloid compound in purslane medicinal material and an extraction and separation method thereof. Background technique [0002] purslane( Portulacaoleracea L. ) is a plant of the family Portulaca oleracea, which is used for toxic heat and bloody dysentery, carbuncle and furuncle, eczema, erysipelas, snake bites, blood in the stool, hemorrhoids, metrorrhagia, etc. The 2010 edition of "The Pharmacopoeia of the People's Republic of China" records that the dried aerial part of purslane is used as medicine, which has the effects of clearing away heat and detoxification, cooling blood and stopping bleeding, and stopping dysentery; modern pharmacological studies have shown that purslane has anti-inflammatory, pain-relieving, antibacterial and antiviral properties. , lowering blood pressure, blood lipids, anti-oxidation, anti-cance...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D487/08A61K31/55A61P29/00
CPCC07D487/08
Inventor 英锡相康廷国英哲铭张文洁艾军军
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com