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Extraction method and application of plant composition containing hypericum perforatum

A technology of Hypericum perforatum and extraction method, which is applied in the directions of drug combinations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of large dosage, many impurities, inconvenient taking of patients, etc., and achieve the effect of reducing dosage.

Inactive Publication Date: 2015-11-25
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of microwave technology in the extraction and preparation of plant compositions containing Hypericum perforatum, but the method of decocting in water is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take. Seriously affected the clinical application of this product

Method used

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  • Extraction method and application of plant composition containing hypericum perforatum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 70 parts of Hypericum perforatum, 50 parts of Coryne chinensis, 60 parts of wild citron, 40 parts of Cinnamon, pulverize, add 2L of 70% ethanol, and put it into a microwave extraction device for microwave extraction. The extraction power is 400-600W. Extract 2 times, 4-8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and Dry to obtain the microwave extract, add conventional excipients to prepare tablets, each tablet is 0.4g.

Embodiment 2

[0016] Take 70 parts of Hypericum perforatum, 50 parts of Coryne chinensis, 60 parts of wild citron, 40 parts of Cinnamon, pulverize, add 2L of 70% ethanol, and put it into a microwave extraction device for microwave extraction. The extraction power is 400-600W. Extract 2 times, 4-8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and Dried to obtain a microwave extract, which is prepared into capsules by adding conventional auxiliary materials.

Embodiment 3

[0018] Take 70 parts of Hypericum perforatum, 50 parts of Coryne chinensis, 60 parts of wild citron, 40 parts of Cinnamon, pulverize, add 2L of 70% ethanol, and put it into a microwave extraction device for microwave extraction. The extraction power is 400-600W. Extract 2 times, 4-8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and Dry to obtain microwave extract, add conventional excipients to prepare granules.

[0019] Hedyotistenelliflora Blume is Hedyotistenelliflora Blume, a plant of the genus Auricularia of Rubiaceae, which is used as medicine with the whole herb. Collected in summer and autumn, washed and dried or used fresh. Qingrejiedu, swelling and pain. For cancer, appendicitis, dysentery; external use for bruises, snake bites.

[0020] Wild citron flower (scientific name: Capparis bodinieri...

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Abstract

The invention provides an extraction method for a plant composition containing hypericum perforatum. The plant composition is prepared from the following crude drugs: 70 parts of hypericum perforatum, 50 parts of meadowrue root and rhizome, 60 parts of capparis bodinieri and 40 parts of hedyotis tenelliflora through a microwave extraction method, so that the content is increased greatly and the dosage is reduced. The invention further provides application of the plant composition containing hypericum perforatum to preparation of drugs for restraining MOLT-4 cell proliferation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to an extraction method and application of a plant composition containing Hypericum perforatum. Background technique [0002] The plant composition containing Hypericum perforatum is made from 70 parts of Hypericum perforatum, 50 parts of Horsetail, 60 parts of wild citron flower, and 40 parts of Herba Cincinnati as raw materials. The current extraction method is to add water and decoct twice, each time After 2-3 hours, combine the decoction, filter, concentrate into a thick paste, granulate, dry, and coat with sugar. [0003] In the prior art, there is no report on the use of microwave technology in the extraction and preparation of plant compositions containing Hypericum perforatum, but the method of decocting in water is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take. Seriously ...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P35/02
Inventor 赵明亮
Owner NANJING ZHENGLIANG MEDICAL TECH
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