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Preparation method and application of refined tablet for treating coronary disease

A technology of Guanxin Tablets and Radix Paeoniae Rubra, which is applied in the field of preparation of refined Guanxin Tablets, can solve the problems of large dosage for patients, many impurities, rough process, etc., and achieve the effect of reducing dosage

Inactive Publication Date: 2014-01-08
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of refined Guanxin Tablets. However, the method of decocting in water is rough, backward, and has many impurities, which leads to excessive dosage for patients, which is inconvenient to take and seriously affects This product has been applied clinically

Method used

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  • Preparation method and application of refined tablet for treating coronary disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Get 375g of Salvia miltiorrhiza, 187.5g of Radix Paeoniae Rubra, 187.5g of Rhizoma Chuanxiong, 187.5g of Safflower, and 125g of Dalbergia radix, join in CO2 supercritical extractor, ethanol is used as entrainer, and entrainer accounts for 4% by volume of total extraction solvent, extracts Pressure 15MPa, temperature 30°C, CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

Embodiment 2

[0018] Take 375g of salvia miltiorrhiza, 187.5g of red peony, 187.5g of Chuanxiong, 187.5g of safflower, and 125g of jiangxiang, and add them to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

Embodiment 3

[0020] Take 375g of salvia miltiorrhiza, 187.5g of red peony, 187.5g of Chuanxiong, 187.5g of safflower, and 125g of jiangxiang, and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

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Abstract

The invention provides a preparation method of a refined tablet for treating a coronary disease. The refined tablet for treating coronary disease is prepared by carrying out supercritical fluid extraction on the following raw herbal materials: 375g of root of red-rooted salvia, 187.5g of radix paeoniae rubra, 187.5g of ligusticum wallichii, 187.5g of carthamus tinctorious and 125g lignum acronychiae, so that the content is greatly increased, and the dose is reduced. The invention also provides application of the refined tablet for treating the coronary disease in the preparation of a medicine for inhibiting the proliferation of a mouse myeloma cell SP2 / 0.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of refined Guanxin tablets. Background technique [0002] Refined Guanxin Tablets are recorded in the Pharmacopoeia, the prescription is 375g of Salvia miltiorrhiza, 187.5g of Radix Paeoniae Rubra, 187.5g of Chuanxiong, 187.5g of Safflower, 125g of Jiangxiang, the above five flavors, and the volatile oil extracted from Jiangxiang, and the distilled aqueous solution is collected separately; the rest of Radix Paeoniae Rubra Wait for Siwei to heat and reflux twice with 85% ethanol, the first time for 3 hours, the second time for 2 hours, filter, combine the filtrate, recover ethanol, combine with the above aqueous solution, and concentrate under reduced pressure to a relative density of 1.35-1.40 (50 ℃), add appropriate amount of auxiliary materials, make granules, dry, add balsamic volatile oil, mix well, press ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K9/20A61P9/10A61P7/00A61P19/08A61P35/00
Inventor 不公告发明人
Owner NANJING ZHENGLIANG MEDICAL TECH
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