Cacumen Platycladi polyphenol capable of reducing activity of uric acid, and preparation method and application of Cacumen Platycladi polyphenol

A oriental orientalis leaf, uric acid-lowering technology is applied to bone diseases, medical raw materials derived from gymnosperm subphylum, drug combinations, etc., and achieves the effects of simple and reasonable preparation process, good thermal stability, and good uric acid-lowering activity.

Active Publication Date: 2015-11-18
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] To sum up, at present, regarding the use of oriental cypress leaves as raw materials, successively undergo ultra-high pressure leaching, atmospheric pressure and high temperature leaching, filtration concentration, macroporous adsorption resin purification, and use the separated and purified polyphenols of oriental cypress leaves to carry out uric acid-lowering activity. There are no reports yet

Method used

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  • Cacumen Platycladi polyphenol capable of reducing activity of uric acid, and preparation method and application of Cacumen Platycladi polyphenol
  • Cacumen Platycladi polyphenol capable of reducing activity of uric acid, and preparation method and application of Cacumen Platycladi polyphenol
  • Cacumen Platycladi polyphenol capable of reducing activity of uric acid, and preparation method and application of Cacumen Platycladi polyphenol

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] (1) 150g of orientalis leaves were dried at 50°C for 6h, then pulverized with a powder machine to obtain the orientalis leaves powder.

[0050] (2) Mix and stir the orientalis leaf powder and water according to the material-to-liquid ratio of 1:15g / mL, seal it with a packaging bag, place it in a polytetrafluoroethylene pressure-transmitting sleeve, and extract it under ultra-high pressure to control the treatment process The medium sample temperature is 35°C, the high pressure treatment condition is 450MPa, and the holding time is 10min. After the treatment, the extract was centrifuged (4000r / min, 15min), and the filtrate was collected.

[0051] (3) Heat the filter residue after high pressure treatment with water until the ratio of solid to liquid is 1:15g / mL, the temperature of hot water is 70°C, and the extraction time is 6h. The resulting extract was centrifuged (4000r / min, 15min), and the filtrate was collected.

[0052] (4) Combine the two leaching filtrates, rem...

Embodiment 2

[0056] (1) 150g of orientalis leaves were dried at 70°C for 5h, then pulverized with a powder machine to obtain the orientalis leaves powder.

[0057] (2) Mix and stir the orientalis leaf powder and water according to the material-to-liquid ratio of 1:20g / mL, seal it with a packaging bag, place it in a polytetrafluoroethylene pressure-transmitting sleeve, and extract it under ultra-high pressure to control the treatment process The medium sample temperature is 35°C, the high pressure treatment condition is 300MPa, and the holding time is 15min. After the treatment, the extract was centrifuged (4000r / min, 15min), and the filtrate was collected.

[0058] (3) Heat the filter residue after high pressure treatment to a solid-liquid ratio of 1:12g / mL, the temperature of the hot water is 80°C, and the leaching time is 4h. The resulting extract was centrifuged (4000r / min, 15min), and the filtrate was collected.

[0059] (4) Combine the two extraction filtrates, remove the insoluble ...

Embodiment 3

[0063] (1) Dry the leaves of orientalis at 90° C. for 3 hours, and then pulverize them with a powder machine to obtain powder of leaves of orientalis.

[0064] (2) Mix and stir the orientalis leaf powder and water according to the material-to-liquid ratio of 1:30g / mL, seal it with a packaging bag, place it in a polytetrafluoroethylene pressure-transmitting sleeve, and extract it under ultra-high pressure to control the treatment process The medium sample temperature is 35°C, the high pressure treatment condition is 100MPa, and the holding time is 20min. After the treatment, the extract was centrifuged (4000r / min, 15min), and the filtrate was collected.

[0065] (3) Add water to the filter residue after high pressure treatment to a solid-liquid ratio of 1:10g / mL, the temperature of the hot water is 95°C, and the extraction time is 3h. The resulting extract was centrifuged (4000r / min, 15min), and the filtrate was collected.

[0066] (4) Combine the two extraction filtrates, re...

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Abstract

The invention relates to Cacumen Platycladi polyphenol capable of reducing activity of uric acid, and a preparation method and application of the Cacumen Platycladi polyphenol. The Cacumen Platycladi polyphenol is obtained by ultra-high-pressure leaching, normal-pressure high-temperature leaching, filtration concentration and macroporous adsorption resin purification. The Cacumen Platycladi polyphenol is high in safety and high in thermal stability. A xanthine oxidase inhivitory activity test proves that the Cacumen Platycladi polyphenol has good uric acid reducing activity, and can be used for preparing functional foods with a uric acid reducing effect or assistant treatment medicines for diseases such as hyperuricemia and gout. A preparation technology is reasonable, simple and environment-friendly, and the Cacumen Platycladi polyphenol is easy to produce widely and industrially.

Description

technical field [0001] The invention relates to the field of natural extracts, in particular to a preparation method and application of arborvitae leaf polyphenols with uric acid-lowering activity. Background technique [0002] Arborvitae ( Platycladus orientalis (L.) Franco ), also known as Xiangkeshu, Xiangshu, Flat Juniper, Cedar, Phellodendron, belonging to the gymnosperm phylum ( Gymnospermae ), Pines and Cypresses ( Coniferopsida ), Pine Pines ( Coniferales ), Cypress ( Cupressaceae ), Arborvitae ( Platycladus ). Sub-categories include Jinta cypress, golden ball cypress, thousand-headed cypress, and narrow-crown arborvitae. The twigs, leaves and fruits of Arborvitae can be used as medicine. It tastes bitter, astringent, and slightly cold in nature. It enters the lung, liver, and large intestine meridian. It has the effects of cooling blood and stopping bleeding, black beard and hair, and relieving cough and asthma. In ancient times, the branches and leaves ...

Claims

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Application Information

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IPC IPC(8): A61K36/14A61P19/06
CPCA61K36/14
Inventor 任娇艳林泽华郑亚美揭异刘丹
Owner SOUTH CHINA UNIV OF TECH
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