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A kind of compound sulfonamide nanoemulsion preparation used by livestock and poultry and preparation method thereof

A technology of compound sulfonamide and milk preparation, which is applied in the field of veterinary medicine, can solve the problems of slow elimination, achieve the effects of enhancing drug efficacy, improving bioavailability, and being easy to use and absorb

Active Publication Date: 2018-01-30
河南亚卫动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its antibacterial activity in the body is 40 times that of TMP, and no drug-resistant strains have been found so far; rapid absorption and slow elimination

Method used

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  • A kind of compound sulfonamide nanoemulsion preparation used by livestock and poultry and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A compound sulfonamide nanoemulsion preparation for livestock and poultry, which is composed of (all components are mass fractions): 2% sulfamethoxine sodium, 0.5% baquipril, 2% soybean oil, Tween 80 1 %, Span 80 1%, ethanol 10%, water 83.5%.

[0025] Preparation:

[0026] (1) Dissolve sulfamethoxine sodium in 10v% water to obtain medicinal solution 1;

[0027] (2) Heat and dissolve baquiprime in ethanol, and control the heating temperature at 60°C to obtain medicinal solution 2;

[0028] (3) Dissolve Tween 80 and Span 80 into soybean oil to obtain liquid medicine 3;

[0029] (4) Mix liquid medicine 2 and liquid medicine 3, and add liquid medicine 1 and the remaining water while stirring until the solution is clear.

Embodiment 2

[0031] A compound sulfonamide nanoemulsion preparation for livestock and poultry, consisting of (all components are mass fractions): 4% sulfamethoxine sodium, 0.8% baquiprime, 4% camellia oil, poloxamer 10%, propylene glycol 20%, water 61.2%.

[0032] Preparation method: (1) Dissolve sulfamethoxine sodium in 20v% water to obtain medicinal solution 1;

[0033] (2) Heat and dissolve baquiprime in propylene glycol, and control the heating temperature at 80°C to obtain medicinal solution 2;

[0034] (3) Dissolving poloxamer into camellia oil to obtain medicinal solution 3;

[0035] (4) Mix liquid medicine 2 and liquid medicine 3, and add liquid medicine 1 and the remaining water while stirring until the solution is clear.

Embodiment 3

[0037] A compound sulfonamide nanoemulsion preparation for livestock and poultry, consisting of (all components are mass fractions): 8% sulfamethoxine sodium, 1.6% baquiprine, 6% corn oil, and 2% olive oil , Maize 52 15%, dimethylformamide 10%, dimethylacetamide 20%, water 37.4%.

[0038] Preparation method: (1) Dissolve sulfamethoxine sodium in 20v% water to obtain medicinal solution 1;

[0039] (2) Baquiprime was heated and dissolved in a mixed solvent of dimethylformamide and dimethylacetamide, and the heating temperature was controlled at 70°C to obtain liquid medicine 2;

[0040] (3) Mix corn oil and olive oil, and dissolve Maize 52 into the aforementioned mixture to obtain liquid medicine 3;

[0041] (4) Mix liquid medicine 2 and liquid medicine 3, and add liquid medicine 1 and the remaining water while stirring until the solution is clear.

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Abstract

A compound sulfonamide nanoemulsion preparation for livestock and poultry and a preparation method thereof, belonging to the technical field of veterinary medicine, comprising the following raw materials in mass percentage: sulfamethoxine sodium 2-10%, baquiprime 0.5-2%, oil Phase 2~10%, emulsifier 2~20%, co-emulsifier 10~40%, and the rest is water. The benefits of the present invention are: (1) the combined use of sulfamethoxine sodium and baquiprine, a sulfa synergist specially used for livestock and poultry, further enhances the drug effect of sulfamethoxine sodium and makes the medicine Quickly kill pathogens in a short period of time, reduce the probability of bacteria producing drug-resistant mutations, and effectively control the emergence of drug resistance; (2) making this compound drug into a nanoemulsion can improve the bioavailability of the drug; (3) This product is an oil-in-water nanoemulsion, which can be diluted with water and drunk directly, which avoids the trouble of mixing ingredients and administering drugs, and is convenient to use.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and relates to a compound sulfonamide nanoemulsion preparation for livestock and poultry and a preparation method thereof. Background technique [0002] In recent years, the phenomenon of antibacterial drug resistance has become more and more serious. Many people think that the use of antibacterial drugs should be limited or even abandoned. Therefore, in the current situation, the scientific and rational use of antibacterial drugs and the avoidance of blind abuse are the effective ways to control bacterial resistance. Among them, reasonable compatibility is also one of the methods worthy of praise. [0003] Sulfamethoxine sodium is the sulfa drug with the strongest antibacterial effect in vivo and in vitro. It has dual pharmacological effects, which can not only be antibacterial, but also antiprotozoal. Streptococcus, pneumococcus, Salmonella, Staphylococcus, Bacillus mallei, Pasteur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K31/635A61P31/04A61K31/506
Inventor 赖登明张遂平郭芳茹苑青艳吴胜耀郭菊王菊萍闫树森牛咏梅
Owner 河南亚卫动物药业有限公司
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