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A kind of pharmaceutical composition for treating diabetes and its application

A technology for diabetes and composition, which can be used in drug combinations, medical preparations containing active ingredients, metabolic diseases, etc., can solve the problems of single action target and large side effects, and achieves low toxic and side effects, low cost and wide practical value. Effect

Active Publication Date: 2018-03-20
成都普瑞法科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] At present, hypoglycemic drugs on the market are mainly chemically synthesized drugs with a single target. Although the curative effect is acceptable, the side effects are large
At present, there is no patent report on the combined application of geniposide and PGG in the treatment of diabetes

Method used

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  • A kind of pharmaceutical composition for treating diabetes and its application
  • A kind of pharmaceutical composition for treating diabetes and its application
  • A kind of pharmaceutical composition for treating diabetes and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Weigh 2 parts of pentagalloyl glucose (PGG) and 1.5 parts of geniposide according to the weight ratio, add pharmaceutically acceptable excipients such as β-cyclodextrin, granulate with a one-step granulator, and use water as a wetting agent. The air inlet temperature is 55-85°C, and the air outlet temperature is 45-65°C to obtain dry granules, which are packaged to obtain granule products. Lubricants can also be added and filled into capsules to obtain capsules.

Embodiment 2

[0060] Weigh 1 part of pentagalloylglucose (PGG) and 1 part of geniposide according to weight ratio, add corn starch, microcrystalline cellulose and other auxiliary materials, adopt wet granulation process to granulate, and dry the wet granules at 65°C for 1.5 After h, use a 24-mesh standard drug sieve to sieve and granulate, add magnesium stearate to compress into tablets, 0.5-0.8g per tablet, coat with a high-efficiency coating machine, and divide into tablets to obtain tablet products.

Embodiment 3

[0062] Weigh 2 parts of pentagalloylglucose (PGG) and 6 parts of geniposide according to the weight ratio, add honey, starch and other auxiliary materials and mix well to make a soft material, use a pelleting machine to make pellets, dry and pack at low temperature to obtain a honeyed pill product.

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Abstract

The invention relates to a pharmaceutical composition for treating diabetes and its application, belonging to the technical field of medicine. The technical problem solved by the present invention is to provide a pharmaceutical composition for treating diabetes. The pharmaceutical composition for treating diabetes of the present invention, the active ingredient is composed of the following components by weight: 1-18 parts of pentagalloyl glucose, 1-12 parts of geniposide. The present invention combines PGG and geniposide in the prevention and treatment of diabetes and its complications, combines the advantages of both in hypoglycemic, anti-inflammatory, anti-oxidation, protection of islet cells, and alleviation of insulin resistance, and provides a new way for clinical treatment of diabetes. Drugs for its complications provide a more comprehensive and effective option. The experimental materials involved in the invention come from original plants, the original plants have a wide range, low cost, clear activity of the extract, less toxic and side effects, and wide practical value.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating diabetes and its application, belonging to the technical field of medicine. Background technique [0002] According to the latest statistics from IDF, in 2013, the global prevalence of diabetes among adults aged 20-79 was 8.3%, and the number of patients has reached 382 million, 80% of which are in middle- and low-income countries, and these countries are rapidly increasing the trend of. It is estimated that by 2035, nearly 592 million people worldwide will suffer from diabetes. Of the current population with diabetes, 175 million (46%) are undiagnosed. In 2013, the global prevalence of impaired glucose tolerance (IGT) was 6.9%, with a total of 316 million patients; this number is expected to increase to 471 million by 2035. [0003] In 2013, a total of 5.1 million people died of diabetes-related diseases worldwide, accounting for 8.39% of all deaths, and the global medical cost of d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P3/10A61K31/7024
Inventor 谢期林罗明锋郭建龙谢海峰
Owner 成都普瑞法科技开发有限公司
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