A kind of preparation method of carboxylated nanocrystalline cellulose reinforced calcium phosphate scaffold

Abstract

A method for preparing a carboxylated nanocrystalline cellulose reinforced calcium phosphate scaffold, the steps of which are: A nanocrystalline cellulose is carboxylated and modified to obtain a carboxylated nanocrystalline cellulose suspension; B preparation of a composite powder: after carboxylation Add soluble calcium salt and soluble phosphate solution sequentially to the nanocrystalline cellulose suspension at a molar ratio of Ca to P of 1.67:1; in situ synthesize hydroxyapatite in the carboxylated nanocrystalline cellulose suspension, by washing, Suction filtration, drying and other operations can obtain the carboxylated nanocrystalline cellulose hydroxyapatite composite powder; C, preparation of the scaffold: the carboxylated nanocrystalline cellulose hydroxyapatite composite powder is used as the solid phase powder of the scaffold alone, Or mix it with other calcium salt powder evenly as the solid phase powder of the stent; add the stent forming liquid, solidify in the water bath after forming, and you can get it. The carboxylated nanocrystalline cellulose-reinforced calcium phosphate scaffold prepared by the method has high compressive strength.

Description

technical field [0001] The invention relates to a calcium phosphate support, in particular to the preparation of a carboxylated nanocrystalline cellulose reinforced calcium phosphate support, which belongs to the field of composite materials. Background technique [0002] Calcium phosphate scaffold (CaP-S) refers to bone scaffolds prepared from calcium phosphate materials (calcium hydrogen phosphate, tetracalcium phosphate powder, α-tricalcium phosphate, β-tricalcium phosphate, hydroxyapatite, etc.). Tissue engineering scaffolds, with good biocompatibility and biodegradability, have been used as clinical bone repair materials. However, CaP-S is an inorganic non-metallic material, which is brittle and has low mechanical strength. For example, its compressive strength is only equivalent to that of cancellous bone, which limits its clinical application. Therefore, it is necessary to improve the mechanical strength of CaP-S to meet the clinical requirements for the mechanical s...

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Problems solved by technology

However, these enhancers lack excellent biocompatibility, will not degrade in the human body, will remain in the body after implantation, and will have adverse effects on humans. Surgical Pain and Financial Burden

CN201410137741.4 discloses an electrospun fiber-reinforced calcium phosphate bone cement composite material and its application, which improves the initial compressive strength of CPC, and degrades the electrospun fiber later, which increases the porosity of CPC, which is beneficial to the growth of tissues , but the fiber preparation process is more complicated, and it is difficult to obtain monodisperse fibers, and the agglomerated fibers are likely to cause stress concentration in CPC

The compressive strength of the enhanced CaP-S prepared by the existing preparation method is generally below 40 MPa, and it is not compatible with the characteristics required by the scaffold such as mechanical strength, biocompatibility and biodegradability

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