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Polymer composite material with hemostasis and anti-adhesion properties and preparation method and application thereof

A composite material and polymer technology, applied in polymer materials and medical fields, can solve problems such as poor adhesion and aggravation of cerebrospinal fluid leakage, and achieve convenient application, good biocompatibility, and prevention of adhesions Effect

Inactive Publication Date: 2015-09-23
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this type of material has the following disadvantages: due to the characteristics of the solid state of the material itself, it cannot be well adhered to the surface of the organ during use.
However, there are other reports that ADCON-L may inhibit dural healing and aggravate CSF leakage

Method used

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  • Polymer composite material with hemostasis and anti-adhesion properties and preparation method and application thereof
  • Polymer composite material with hemostasis and anti-adhesion properties and preparation method and application thereof
  • Polymer composite material with hemostasis and anti-adhesion properties and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: the synthesis of PLGA-PEG-PLGA block copolymer

[0031] Add 30 g PEG (1500) into a 250 mL four-neck flask, heat the oil bath to 130 °C, vacuum filter for 3 h with stirring to remove the residual moisture in the PEG, and then add 58 g DL-lactate under the protection of argon After the ester (LA) and 6 g glycolide (GA) were completely melted, 0.1 wt% stannous octoate was added, and the oil bath was heated to 150 °C to continue the reaction for 12 h. After the reaction was completed, the unreacted monomers and low-boiling products in the system were removed by vacuum filtration for 2 h. Finally, the initial product was placed in hot water at 80°C, stirred and washed, allowed to stand for precipitation, and the upper layer solution was removed. The washing was repeated three times, and the residual water was removed by freeze-drying to obtain the final product with a yield of about 80%. The number-average and weight-average molecular weight ( M n , M w )...

Embodiment 2

[0032] Embodiment 2: the synthesis of MPEG-PLGA block copolymer

[0033] Add 11 g of monomethoxy-terminated polyethylene glycol MPEG (550) into a 250 mL four-necked flask, heat the oil bath to 130 °C, and vacuum filter for 3 h while stirring to remove residual moisture in MPEG, and then 26.7 g DL-lactide (LA) and 4.3 g glycolide (GA) were added under gas protection, and after complete melting, 0.1 wt% stannous octoate was added, and the oil bath was heated to 150 °C to continue the reaction for 12 h. After the reaction was completed, the unreacted monomers and low-boiling products in the system were removed by vacuum filtration for 2 h. The initial product was dissolved in dichloromethane solution and precipitated with ether, the yield was about 85%. The number-average and weight-average molecular weight ( M n , M w ) are 2850 and 3730 respectively, the molecular weight distribution coefficient ( M w / M n ) is 1.31.

Embodiment 3

[0034] Embodiment 3: the synthesis of PCGA-PEG-PCGA block copolymer

[0035] Add 30 g PEG (1500 °C) into a 250 mL four-neck flask, heat the oil bath to 130 °C, and vacuum filter for 3 h with stirring to remove the residual moisture in the PEG, during which the argon gas was replaced more than three times. Then, 50 g ε-caprolactone (CL) and 25 g glycolide (GA) were added under the protection of argon. After complete melting, 0.1 wt% stannous octoate was added, and the temperature of the oil bath was raised to 150 °C to continue the reaction for 12 h. After the reaction was completed, the unreacted monomers and low-boiling products in the system were removed by vacuum filtration for 2 h. The initial product was dissolved in dichloromethane solution, ether precipitated, and the yield was about 80%. The number-average and weight-average molecular weight ( M n , M w ) are 7260 and 9570 respectively, the molecular weight distribution coefficient ( M w / M n ) is 1.32.

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Abstract

The invention belongs to the technical field of high polymer materials and medical treatment, and particularly relates to a polymer composite material with hemostasis and anti-adhesion properties and a preparation method and application thereof. The system of the composite material is formed by an amphipathy segmented copolymer, a solvent taking water as a main part, and a hemostatic drug jointly; the polymer composite material can be subject to thermotropic gelation phase transformation along with high temperature, is in a solution state when temperature is lower than sol-gel transformation temperature, and spontaneously forms gel when the temperature is higher than the sol-gel transformation temperature, and this process is reversible; a solution system has thermosensitivity property and can spontaneously form the gel under body temperature; after being coated on a postoperative wound face, the material solution has hemostasis and anti-wound-face-adhesion effects.

Description

technical field [0001] The invention belongs to the field of polymer materials and medical technology, and in particular relates to a physically cross-linked thermogenic hydrogel material loaded with hemostatic drugs. Background technique [0002] Postoperative adhesion is an important problem that has plagued the surgical field for a long time. During the wound healing process, the newly formed scar tissue adheres to other tissues, causing postoperative pain and other complications, requiring a second operation, which brings great pain to the patient. Epidural scar adhesions after laminectomy often compress nerve roots, leading to recurrence of low back and leg pain; adhesions after abdominal surgery can lead to a series of complications such as adhesive small bowel obstruction, pelvic pain, and female infertility Intrauterine adhesions cause clinical complications such as hypomenorrhea, amenorrhea, and infertility in women; tendon adhesions after tendon repair surgery wil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/06A61L31/14
Inventor 俞麟陈琳丁建东
Owner FUDAN UNIV
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