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Method for analyzing pathogenesis of cornea related diseases

A mechanism analysis, corneal technology, applied in the field of biomedicine, can solve the problems of Fox endothelial corneal dystrophy, poor understanding of the pathogenic mechanism of corneal diseases, etc.

Inactive Publication Date: 2015-09-16
JIANGSU UNIV
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Problems solved by technology

[0002] As we all know, the cornea is an essential functional tissue for human beings. It is a transparent layer located at the front of the eyeball. It plays an important role in the protection of refraction and eyeball; because of the special structure and important role of the cornea, cornea-related diseases will have a huge impact on the normal production and life of human beings. At present, the world has invested huge resources for different Although great progress has been made in the research on corneal diseases, the microscopic pathogenic mechanism of many corneal diseases is still poorly understood, such as the common Fox endothelial corneal dystrophy, so corneal transplantation is still the main curative method

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  • Method for analyzing pathogenesis of cornea related diseases
  • Method for analyzing pathogenesis of cornea related diseases
  • Method for analyzing pathogenesis of cornea related diseases

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[0021] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments.

[0022] 1 Example disease introduction

[0023] Fox endothelial corneal dystrophy is a relatively common corneal disease mainly affecting the elderly; the main symptom is that due to the massive death of cells in the endothelial layer, the descemet's membrane is adversely affected, eventually thickening, clouding, and stinging blister. Ultimately vision loss or even blindness; although people have reached a consensus on the cause of the disease at the physiological level, the current diagnosis and analysis of corneal-related diseases mainly rely on optical instruments, limited by the energy and wavelength of the light source, for the descemet membrane The microscopic causes of thickening and blisters are still poorly understood; it is well known that the main components of the cornea a...

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Abstract

The invention relates to a method for analyzing pathogenesis of cornea related diseases, and belongs to the field of biomedical technologies. Specifically, the invention relates to a method for recognizing and analyzing the pathogenesis of the cornea related diseases at a nanometer scale by using a specific instrument. According to the invention, an auxiliary analysis method for the pathogenesis of the cornea related diseases is provided from such two aspects as morphology and related mechanical properties at the nanometer scale by using a quantitative nanomechanics atomic force microscope, and detailed elaboration is conducted by taking a Fuchs endothelial cornea dystrophy disease as an example, thereby providing the universality of the method in cornea related disease research.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular, the invention relates to a method for identifying and analyzing the pathogenic mechanism of corneal-related diseases on a nanometer scale by using a specific instrument. Background technique [0002] As we all know, the cornea is an essential functional tissue for human beings. It is a transparent layer located at the front of the eyeball. It plays an important role in the protection of refraction and eyeball; because of the special structure and important role of the cornea, cornea-related diseases will have a huge impact on the normal production and life of human beings. At present, the world has invested huge resources for different Although considerable progress has been made in research on corneal diseases, the microscopic pathogenic mechanisms of many corneal diseases are still poorly understood, such as the common Fox endothelial corneal dystrophy, so corneal transpl...

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Application Information

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IPC IPC(8): G01Q60/24
Inventor 董明东张帅夏丹
Owner JIANGSU UNIV
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