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Decoquinate nanometer preparation and preparing method and application thereof

A technology of decoquinate and nano preparations, applied in the field of medicine

Active Publication Date: 2015-09-16
BLUE ELEGANT BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no product for the prevention and treatment of malaria with decoquinate as the active ingredient

Method used

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  • Decoquinate nanometer preparation and preparing method and application thereof
  • Decoquinate nanometer preparation and preparing method and application thereof
  • Decoquinate nanometer preparation and preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Composition:

[0065] Decoxyquinate (Sigma, St.Louis, MO.USA, USA) 200mg

[0066] Egg Yolk L-α-Phosphatidylcholine (PC) (Sigma, St.Louis, MO.USA) 334mg

[0067] Tween 80 (Tween 80) (Sigma, St.Louis, MO.USA, USA) 200mg

[0068] Weigh each component according to the above mass, add ethanol (the amount added depends on the sample size), heat to 65°C until each component is completely dissolved, remove the ethanol with a rotary evaporator, transfer the sample to a glass container, and make the ethanol further volatile. Collect powdery samples, add 20ml of water (glucose quality is 400mg). The sample was ultrasonicated for 3 hours at room temperature by an ultrasonic instrument with a power of 500W and a frequency of 40KHz (GT-2227QTS ultrasonic instrument of Guangdong Gute Ultrasonic Industrial Co., Ltd.), and the particles in the sample were reduced to below 300nm. After the sample was freeze-dried, decane oxide was obtained. Quinolate nano-preparation.

Embodiment 2

[0070] Composition:

[0071]

[0072]

[0073] The preparation process of the decoquinate nano-preparation is the same as in Example 1.

Embodiment 3

[0075] Composition:

[0076]

[0077] The preparation process of the decoquinate nano-preparation is the same as in Example 1.

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Abstract

The invention discloses a decoquinate nanometer preparation. The decoquinate nanometer preparation comprises decoquinate and an amphipathy surface active agent which is L-alpha phosphatidylcholine. The grain size of the decoquinate nanometer preparation is not larger than 300 nm. The dissolution rate of the active ingredient decoquinate is increased through introduction of the amphipathy surface active agent, the specific surface area of the decoquinate nanometer preparation with the grain size not larger than 300 nm is increased, the dissolution rate of the decoquinate is increased, and the absorption by the intestinal tract is effectively improved. In general, the dissolution rate of the decoquinate in the decoquinate nanometer preparation, the bioavailability and the malaria resisting drug effect are far higher than those of the micrometer decoquinate preparation. The invention further provides a preparing method for the decoquinate nanometer preparation. By means of introduction of the amphipathy surface active agent and an ultrasonic or high-pressure homogenate method, the micrometer decoquinate preparation is scattered into the decoquinate nanometer preparation.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a decoquinate nano-preparation and its preparation method and application. Background technique [0002] Malaria is a disease caused by the parasite Plasmodium that is transmitted by the bite of an Anopheles mosquito. After the malaria parasite reaches the human body through mosquito bites, it first develops from sporozoites into merozoites in the liver, and then infects red blood cells. Plasmodium infects red blood cells, causing symptoms such as fever, headache, fatigue and vomiting. These symptoms usually appear 10 to 15 days after the mosquito bite. Patients usually need timely treatment, otherwise it will damage the patient's vital organs and even threaten the patient's life safety. According to statistics from the World Health Organization in 2013, nearly 3.4 billion people in 97 countries are at risk of suffering from malaria, of which 1.2 billion are at hi...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/47A61K47/24A61K9/20A61K9/16A61K9/48A61P33/06
CPCY02A50/30
Inventor 王洪星陈雪清范银洲覃丽梅许婉婉秦莉赵思婷陈小平
Owner BLUE ELEGANT BIOTECH CO LTD
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