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Copper metal complex and compound of copper metal complex and human serum albumin, as well as synthesis methods and application of copper metal complex and compound

A technology of human serum albumin and a synthesis method, applied in the field of copper metal complexes and their complexes with human serum albumin, to achieve the effect of good medicinal value

Inactive Publication Date: 2015-08-19
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no public report on the synthesis and pharmacological activity of copper (II) metal complexes with 2-dipyridylketal 4,4'-dimethyl-3-thiosemicarbazide as ligands

Method used

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  • Copper metal complex and compound of copper metal complex and human serum albumin, as well as synthesis methods and application of copper metal complex and compound
  • Copper metal complex and compound of copper metal complex and human serum albumin, as well as synthesis methods and application of copper metal complex and compound
  • Copper metal complex and compound of copper metal complex and human serum albumin, as well as synthesis methods and application of copper metal complex and compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: [Cu(Dp44mT)Cl] 2 Synthesis of complexes

[0034] The synthetic route is as follows:

[0035]

[0036] The specific synthesis method is:

[0037]1) Dissolve 10mmol of 2-dipyridyl ketone (1833.1mg) in 20ml of ethanol (the concentration of solvent ethanol is 50v / v%), stir at 60°C for 15min to obtain a solution, and add the above solution dropwise to Add 10mmol 4,4'-dimethyl-3-thiosemicarbazide (1191.9mg) in 20ml of ethanol (concentration of solvent ethanol: 50v / v%) solution, reflux and stir at 60°C for 24h to obtain a light yellow precipitate, The light yellow precipitate obtained above was filtered, washed three times with absolute ethanol and ether, and dried to obtain the ligand 2-dipyridyl ketal 4,4'-dimethyl-3-thiosemicarbazide;

[0038] 2) will contain CuCl 2 2H 2 O (170.48mg, 1mmol) 20ml of methanol (the concentration of solvent methanol is 60v / v%) solution, dropwise added to the solution containing 1mmol 2-dipyridyl ketal 4,4'-dimethyl-3-thiosemi...

Embodiment 2

[0051] Example 2: [Cu(Dp44mT)Cl] 2 Synthesis of complexes

[0052] 1) Dissolve 10mmol of 2-dipyridyl ketone (1833.1㎎) in 10ml of methanol (the concentration of solvent methanol is 80v / v%), stir at 50°C for 15min to obtain a solution, and add the above solution dropwise to Add 10mmol 4,4'-dimethyl-3-thiosemicarbazide (1191.9mg) in 20ml of ethanol (concentration of solvent ethanol: 20v / v%) solution, reflux and stir at 80°C for 18h to obtain a light yellow precipitate , after filtering the light yellow precipitate obtained above, washing with water three times, and drying, the ligand 2-dipyridyl ketal 4,4'-dimethyl-3-thiosemicarbazide was obtained;

[0053] 2) will contain CuCl 2 2H 2 O (170.48mg, 1mmol) 20ml of ethanol (concentration of solvent ethanol is 40v / v%) solution, dropwise added to the solution containing 1mmol 2-dipyridyl ketal 4,4'-dimethyl-3-thiosemicarbazide 20ml of ethanol (the concentration of solvent ethanol is 70v / v%) solution, reflux and stir at 50°C for 2h...

Embodiment 3

[0054] Example 3: [Cu(Dp44mT)Cl] 2 Synthesis of complexes

[0055] 1) Dissolve 10mmol of 2-dipyridyl ketone (1833.1㎎) in 10ml of methanol (the concentration of solvent methanol is 80v / v%), stir at 50°C for 15min to obtain a solution, and add the above solution dropwise to Add 10mmol 4,4'-dimethyl-3-thiosemicarbazide (1191.9mg) in 20ml of methanol (concentration of solvent methanol: 60v / v%) solution, stir at 35°C for 48h, and get a pale yellow precipitate The above-mentioned light yellow precipitate was filtered, washed three times with methanol, and dried to obtain the ligand 2-dipyridyl ketal 4,4'-dimethyl-3-thiosemicarbazide;

[0056] 2) will contain CuCl 2 2H 2 O (170.48mg, 1mmol) 20ml of ethanol (the concentration of solvent ethanol is 30v / v%) solution, dropwise added to the solution containing 1mmol 2-dipyridyl ketal 4,4'-dimethyl-3-thiosemicarbazide 20ml ethanol (the concentration of solvent ethanol is 20v / v%) solution, stirred at 40°C for 36h, filtered the reacted s...

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PUM

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Abstract

The invention discloses a copper metal complex and a compound of copper metal complex and human serum albumin, as well as synthesis methods and application of the copper metal complex and the compound. The synthesis method for the copper metal complex comprises the following steps of reacting 2-di-pyridyl ketone with 4,4minute-dimethyl-3-thiosemicarbazide to generate precipitates by taking an alcohol substance as a solvent, and collecting and washing the precipitates to obtain ligands; reacting the ligands with CuCl2.2H2O by taking an alcohol substance as a solvent, standing and crystallizing a reaction product, and collecting crystals to obtain the copper metal complex. The compound is obtained by incubating the copper metal complex and the human serum albumin by adopting a solution method. The structure of the copper metal complex is shown in Formula (I).

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a copper metal complex and its complex with human serum albumin, as well as their synthesis method and application. Background technique [0002] Cancer (mainly referring to malignant tumors) is one of the most serious diseases that endanger human health. The most common and serious malignant tumors in my country mainly include: breast cancer, cervical cancer, lymphoma, leukemia, lung cancer, liver cancer and other types (Farrell N , et al. Cancer Res., 1992), and antineoplastic drugs are gradually developed along with the great threat of cancer to human health. After decades of research and development by scientific researchers, different types of anti-tumor drugs with different efficacy characteristics and different mechanisms of action have been launched and applied in clinical treatment and adjuvant therapy. Among them, in 1965, Rosenberg et al. found that cisplatin had sign...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F1/08A61K31/555C07K14/765A61K38/38A61K47/42A61P35/00
CPCA61K38/385A61K47/42C07F1/08C07K14/765
Inventor 杨峰梁宏齐金旭
Owner GUANGXI NORMAL UNIV
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