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A combined medicine combination with anti-Candida albicans effect, its preparation method and dosage form, and application of nasturtium ethanolic extract

A technology of ethanol extraction and Candida albicans, which is applied in the field of medicine, can solve the problems that the antifungal effect of nasturtium has not been reported in the literature, and achieve the effects of improving the body's immune function, increasing antibacterial effect, and having a wide range of sources

Active Publication Date: 2018-04-27
河北百善医药科技有限公司
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AI Technical Summary

Problems solved by technology

Clinically, it is mainly used for the treatment of cold, fever, tonsillitis, pharyngitis, urinary tract infection, etc., but there is no literature report on the antifungal effect of nasturtium

Method used

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  • A combined medicine combination with anti-Candida albicans effect, its preparation method and dosage form, and application of nasturtium ethanolic extract
  • A combined medicine combination with anti-Candida albicans effect, its preparation method and dosage form, and application of nasturtium ethanolic extract
  • A combined medicine combination with anti-Candida albicans effect, its preparation method and dosage form, and application of nasturtium ethanolic extract

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Embodiment 1

[0027] Example 1: A combined drug combination with anti-Candida albicans effect:

[0028] A combined drug combination of anti-Candida albicans effect, including the former drug of fluconazole, wherein, the combined drug combination also includes the ethanol extract of Trollica chinensis, wherein the weight ratio of fluconazole and the ethanol extract of Trollius chinensis is 1:2.5;

[0029] Described nasturtium ethanol extract is prepared by the following method:

[0030] After the nasturtium is dried and crushed, add 70% ethanol at a ratio of 1g:20ml, extract twice in a water bath at 70°C, each time for 2h, filter, combine the extracts, recover ethanol, and dry the extract after recovering ethanol in a water bath at 70°C. That is the ethanol extract of Trollus chinensis.

[0031] The beneficial effects of a combined drug combination with anti-Candida albicans effect of the present invention and the effect of the Trollica ethanol extract on enhancing the anti-Candida albica...

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Abstract

The invention relates to a combination drug combination with anti-candida albicans effect, its preparation method, dosage form and application of the ethanol extract of nasturtium flower, belonging to the technical field of medicine. The combined drug combination includes the original drug of fluconazole and the ethanol extract of Trollica chinensis, wherein the weight ratio of the original drug of fluconazole and the ethanol extract of Trollica chinensis is 1:2.5. The combined drug combination of the present invention has the following advantages: synergistic effect and complementary advantages; obvious effect and safety, and the ethanol extract of nasturtium can increase the antibacterial effect of fluconazole, reduce the dosage of fluconazole and its adverse reactions, and can reduce The drug resistance of Candida albicans to fluconazole can increase its antibacterial activity; the ethanol extract of nasturtium can improve the immune function of the body and enhance the disease resistance, and no toxic and side effects have been found in the combined application of the two.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a joint drug combination for anti-candida albicans, its preparation method and dosage form, and the application of the ethanol extract of nasturtium. Background technique [0002] Candida vaginitis is a common gynecological disease in women. A large number of studies have shown that 85%-90% of infections are caused by Candida albicans. Candida albicans is the main conditional pathogen of the human body, and people with low immune function are prone to disease. At present, azole antifungal drugs are mostly used clinically for candidal vaginitis, but with the extensive application of them, drug resistance to azole drugs gradually appears, resulting in reduced or ineffective drug efficacy. Therefore, it is very necessary to find drugs or methods to reduce the drug resistance of Candida albicans and increase the curative effect of azole drugs. [0003] Trollius chinen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61P15/02A61P31/10A61K31/4196
Inventor 韩志强韩淑英王明泽王志璐王潇颖
Owner 河北百善医药科技有限公司
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