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Preparation method and quality control method of coptis root detoxifcation soup particles

The technology of Huanglian Jiedu Decoction and formula granules is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, antidote and the like, which can solve problems such as precipitation, and achieve the effects of simple preparation method, obvious effect and precise curative effect.

Active Publication Date: 2015-08-12
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to overcome the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a preparation method and quality control method of Huanglian Jiedu Decoction formula granules, which can effectively solve the problem of precipitation when the extract of Huanglian Jiedu Decoction is concentrated. The active ingredients in the raw materials are kept to a maximum extent, which can be widely used in large-scale production; the quality control method is simple, comprehensive, and can effectively control the quality of the produced Huanglian Jiedu Decoction Formula Granules, which can be used in daily quality control work

Method used

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  • Preparation method and quality control method of coptis root detoxifcation soup particles
  • Preparation method and quality control method of coptis root detoxifcation soup particles
  • Preparation method and quality control method of coptis root detoxifcation soup particles

Examples

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Effect test

Embodiment 1

[0044] a. Take 750g of Coptis chinensis, 500g of Scutellaria baicalensis, 500g of Cortex Phellodendron, and 750g of Gardenia, add water to decoct twice, add 25kg of water for the first time, decoct for 1 hour; add 30kg of water for the second time, decoct for 1.5 hours, and combine the filtrate , filter;

[0045] b. Concentrate the filtrate under reduced pressure in vacuo to an extract with a relative density of 1.04 at 95°C. At this time, a large amount of precipitation occurs in the extract, add 351g of β-cyclodextrin, keep the extract at 95°C, fully stir, and mix well to obtain clear ointment;

[0046] c. Take the above clear paste, add an appropriate amount of maltodextrin, spray dry, control the air inlet temperature at 175°C~185°C, and the outlet air temperature at 85°C~95°C to obtain dry extract powder, then add an appropriate amount of maltodextrin, and mix , carry out dry granulation, and finally obtain granules with a particle size in the range of 16-40 mesh and uni...

Embodiment 2

[0050] a. Take 450g of Coptidis Rhizome, 300g of Scutellaria Baicalensis, 300g of Phellodendron Phellodendron, and 450g of Gardenia, add water to decoct twice, add 15kg of water for the first time, decoct for 1.5 hours; add 12kg of water for the second time, decoct for 1 hour, and combine the filtrate , filter;

[0051] b. Concentrate the filtrate under reduced pressure in vacuum to an extract with a relative density of 1.05 at 95°C. At this time, a large amount of precipitation appears in the extract, add 210g of β-cyclodextrin, keep the extract at 100°C, stir and mix well Deqing ointment;

[0052] c. Take the above clear paste, add an appropriate amount of maltodextrin, spray dry, control the air inlet temperature at 175°C~185°C, and the outlet air temperature at 85°C~95°C to obtain dry extract powder, then add an appropriate amount of maltodextrin, and mix , carry out dry granulation, and finally obtain granules with a particle size in the range of 16-40 mesh and uniform c...

Embodiment 3

[0056] a. Take 900g of Coptis chinensis, 600g of Scutellaria baicalensis, 600g of Cortex Phellodendron, and 900g of Gardenia, add water to decoct twice, add 24kg of water for the first time, decoct for 2 hours; add 36kg of water for the second time, decoct for 1.5 hours, and combine the filtrate , filter;

[0057] b. The filtrate is concentrated under reduced pressure in vacuum to an extract with a relative density of 1.03 at 95°C. At this time, a large amount of precipitation occurs in the extract, and 421g of β-cyclodextrin is added. The extract is kept at 90°C, fully stirred, and mixed to obtain clear ointment;

[0058] c. Take the above clear paste, add an appropriate amount of maltodextrin, spray dry, control the air inlet temperature at 175°C~185°C, and the outlet air temperature at 85°C~95°C to obtain dry extract powder, then add an appropriate amount of maltodextrin, and mix , carry out dry granulation, and finally obtain granules with a particle size in the range of ...

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Abstract

The invention discloses a preparation method and a quality control method of coptis root detoxifcation soup particles. The preparation method comprises decocting coptis root, radix scutellariae, phellodendron and cape jasmine decoction pieces in water 2 times, filtering the decoctions, merging the filtrate, carrying out vacuum concentration on the filtrate, adding beta-cyclodextrin into the filtrate, carrying out stirring to obtain clear paste, carrying out spray drying on the clear paste, and carrying out dry method granulation to obtain the coptis root detoxifcation soup particles. The quality control method comprises thin layer qualitative identification and HPLC content determination. The preparation method effectively solves the problem that the coptis root detoxifcation soup produces precipitates in condensation, maximumly retains effective components in raw materials, and can be widely used in massive production. The quality control method realizes simple, comprehensive and effective control of coptis root detoxifcation soup particle quality and can be used in daily quality control.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and in particular relates to a preparation method of Huanglian Jiedu Decoction formula granules and a quality control method thereof. Background technique [0002] Huanglian Jiedu Decoction was first recorded in Ge Hong's "Elbow Reserve Emergency Prescription", which was used to treat typhoid fever, but the name of the prescription was not given; Tang Wang Tao's "Waitai Miyao" cited Cui's prescription, and it was first named Huanglian Jiedu Decoction , has a history of 1700 years of application. The prescription is composed of Coptis chinensis, Scutellaria baicalensis, Cortex Phellodendron, and Gardenia, and is a representative prescription for clearing away heat and detoxifying. This formula combines Coptis chinensis, Scutellaria baicalensis, Phellodendron Phellodendron, and Gardenia in one side, which are bitter and cold, and Coptis chinensis is used as th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K9/16A61P39/02G01N30/90G01N30/02
Inventor 谭登平霍文杰杜兰哲官永河李慧王闽予
Owner GUANGDONG YIFANG PHARMA
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