Near-infrared fluorescence dye for targeting tumor tissue as well as preparation method and application

Abstract

The invention discloses near-infrared fluorescence dye for targeting tumor tissue. The structure of the near-infrared fluorescence dye for targeting tumor tissue is shown in formula I. Additionally, the invention further discloses a preparation method and an application of the near-infrared fluorescence dye. The near-infrared fluorescence dye has the characteristics of water solubility, near-infrared color rendering, tumor cell targeting and the like and is applicable to transmission in in-vivo environment; a near-infrared fluorescence area has color rendering, eliminates disturbance of other light sources and can serve as near-infrared dye; meanwhile, accumulation of the dye around the tumor tissue is improved according to a folic acid targeting principle, specific locus recognition capacity is provided, and the near-infrared fluorescence dye can serve as dye in a tumor resection operation and used for targeting near-infrared images of tumor cells. The property of the near-infrared fluorescence dye helps surgeons to look for and judge positions of tumor tissue in time in an operation process, the purpose of eradicating residual tumors is achieved, and the near-infrared fluorescence dye has a wide application prospect in the field of targeted color rendering of the tumor cells in an medical operation.

Description

technical field [0001] The invention belongs to the technical field of near-infrared fluorescent dyeing agents, and in particular relates to a near-infrared fluorescent dyeing agent for targeting tumor tissues, a preparation method and an application thereof. Background technique [0002] Medical imaging technology has greatly improved the accuracy of doctors' diagnosis of the cause and location of lesions, the stage of disease development, and later recovery treatment, such as X-ray computed tomography (CT), positron emission tomography (PET), single Photon Emission Computed Tomography (SPECT), Spectral Imaging (FI) and Magnetic Resonance Imaging (MRI). However, compared with the medical imaging technology in the diagnostic stage, the imaging diagnostic technology in surgery, especially the imaging technology for judging tumor tissue, directly affects the success or failure of resection surgery and the postoperative rehabilitation effect of patients. The unfortunate fact i...

AI Technical Summary

Problems solved by technology

This reality makes it impossible to completely remove tumor tissue in up to 25% of cases during resection of tumor tissue; this situation further leads to a local recurrence rate of cancer cells as high as 28%

In addition, although the existing technical means, such as CT and intraoperative ultrasound evaluation, can roughly determine and judge the extent of tumor tissue, 6% to 20% of tumor tissue metastasis cannot be detected, especially for ultra-small (<5mm ) metastases

Therefore, accurately judging the location of tumor tissue that needs to be removed, avoiding damage to the structure of normal tissue, and finding small metastatic lesions pose new challenges for clinical surgical techniques.

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