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Application of AMF (amifostine) in tumors with high Cyclin D1 expression

A cyclin, high expression technology, applied in the field of biomedicine

Active Publication Date: 2015-07-29
潍坊峡山精准数基生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are no literature reports on the potential target molecules or signaling pathways of amifostine's anti-tumor effect

Method used

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  • Application of AMF (amifostine) in tumors with high Cyclin D1 expression
  • Application of AMF (amifostine) in tumors with high Cyclin D1 expression
  • Application of AMF (amifostine) in tumors with high Cyclin D1 expression

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Embodiment Construction

[0029] The present invention will be further clarified through the detailed description of specific embodiments below, but it is not intended to limit the present invention, but only for illustration.

[0030] Bioinformatics method predicts that amifostine can inhibit the high expression of CyclinD1

[0031] (1) Bioinformatics methods

[0032] ① Data source: Searching for free gene expression databases open on the Internet with "amifostine" as the keyword, these databases include: Gene expression omnibus (GEO), gene chip expression database Affymetrix (Hu35KsubB, Hu35KsubD, HG-U95A, HG-U133A, HG-U133B, HG-U95Av2, HuGeneF, HG-Focus, HG-U-133 Plus), Clontech (Atlas Human Toxicology 1.2 Array, Atlas Plastic Human 8K Microarray, Atlas Glass Human 3.8 I Microarray and MWG Human 30k Array); gene expression databases SAGE, GeneCard, InterPro, ProtoNet, UniProt, and BLOCKS.

[0033] ②Validity test of data: test the obtained raw data to judge whether it is suitable for further analys...

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Abstract

The invention discloses an application of AMF (amifostine) in treatment of tumors with high Cyclin D1 expression. According to research, AMF inhibits tumor cell growth by inhibiting cancer gene CyclinD1 expression in a targeted manner and resists the tumors by inhibiting the CyclinD1 expression in a targeted manner, and the functions are successfully verified through megakaryocyte leukemia cell lines Dami; and AMF successfully cures mantle cell lymphoma with high Cyclin D1 expression and high leukocyte expression as characteristics in clinical practice.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the application of amifostine in tumors with high expression of cyclin D1. Background technique [0002] Cyclin D1 (CyclinD1) is highly expressed in a variety of tumor cells, including mantle cell lymphoma, acute and chronic leukemia, breast cancer, esophageal cancer, lung cancer, prostate cancer, thyroid cancer, myeloma, head and neck tumors, sarcoma, Gastric cancer, cervical cancer, colon cancer, glioma, etc., are ideal targets for tumor therapy. However, there is currently a lack of clinically targeted targeted therapy drugs. [0003] The molecular mechanism of cyclin D1 (CyclinD1) carcinogenesis is as follows: [0004] 1. Biological functions of CyclinD1 and p16 and their regulation mechanism on cell cycle [0005] The division of eukaryotic cells must start DNA synthesis through G1→S phase transition, and enter mitosis through G2→M phase transition, in which CyclinD1 is closely r...

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Application Information

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IPC IPC(8): A61K31/661A61P35/00A61P35/02
Inventor 杨波卢学春迟小华
Owner 潍坊峡山精准数基生物科技有限公司
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