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A Three-dimensional Microscaffold Composite Porous Metal Scaffold Adhering to Platelets

A porous metal and platelet technology, applied in the field of biomedical materials, can solve the problems of small application range, lack of biological activity, insufficient mechanical strength of biodegradable materials, etc., and achieve the effect of no immune rejection and convenient source.

Active Publication Date: 2017-04-19
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The platelet-adhering three-dimensional micro-stent composite porous metal stent of the present invention not only overcomes the defect that the porous metal stent lacks biological activity, but also overcomes the defect that the biodegradable material has insufficient mechanical strength resulting in a small application range

Method used

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  • A Three-dimensional Microscaffold Composite Porous Metal Scaffold Adhering to Platelets
  • A Three-dimensional Microscaffold Composite Porous Metal Scaffold Adhering to Platelets
  • A Three-dimensional Microscaffold Composite Porous Metal Scaffold Adhering to Platelets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 Preparation of platelet-adhered three-dimensional microscaffold composite porous titanium alloy scaffold

[0052] 1. Preparation of porous titanium alloy scaffold

[0053] (1) Import the CT image into 3D image software such as Mimics or CAD to obtain a 3D image of the target bone tissue. The average pore column is 100 μm and the pore diameter is 300 μm. The image is filled and expanded with regular hexahedral units to obtain a personalized porous connected 3D image. digital model.

[0054] (2) EOS M280 metal material 3D printer was used to print porous titanium alloy scaffolds based on the design model with titanium alloy (Ti-6Al-4V) as the raw material.

[0055] 2. Preparation of gelatin three-dimensional microscaffold composite porous titanium alloy scaffold

[0056] (1) The gelatin particles were soaked in deionized water for 2 hours, and at the same time stirred at 37° C. under the action of a magnetic stirrer at 300 r / min until completely dissolved, wit...

Embodiment 2

[0062] Example 2 Preparation of platelet-adhered three-dimensional microstent composite porous titanium alloy scaffold

[0063] 1. Preparation of porous titanium alloy scaffold

[0064] (1) Import the CT image into three-dimensional image software such as Mimics or CAD to obtain a three-dimensional image of the target bone tissue. The average pore column is 300 μm and the pore diameter is 1000 μm. The image is filled and expanded with regular dodecahedron units to obtain personalized porous Connected 3D digital models.

[0065] (2) EOS M280 metal material 3D printer was used to print porous titanium alloy scaffolds based on the design model with titanium alloy (Ti-6Al-4V) as the raw material.

[0066] 2. Preparation of gelatin three-dimensional microscaffold composite porous titanium alloy scaffold

[0067] (1) The gelatin particles were soaked in deionized water for 2 hours, and at the same time stirred at 37° C. under the action of a magnetic stirrer at 300 r / min until com...

Embodiment 3

[0073] Example 3 Preparation of platelet-adhered three-dimensional microscaffold composite porous titanium alloy scaffold

[0074] 1. Preparation of porous titanium alloy scaffold

[0075] (1) Import the CT image into three-dimensional image software such as Mimics or CAD to obtain a three-dimensional image of the target bone tissue. The average pore column is 300 μm and the pore diameter is 1000 μm. The image is filled and expanded with regular dodecahedron units to obtain personalized porous Connected 3D digital models.

[0076] (2) EOS M280 metal material 3D printer was used to print porous titanium alloy scaffolds based on the design model with titanium alloy (Ti-6Al-4V) as the raw material.

[0077] 2. Preparation of gelatin three-dimensional microscaffold composite porous titanium alloy scaffold

[0078] (1) The gelatin particles were soaked in deionized water for 2 hours, and at the same time stirred at 37° C. under the action of a 300 r / min magnetic stirrer until com...

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Abstract

The invention discloses a three-dimensional micro stent composite porous metal support for adhering blood platelets. The method for preparing the composite porous metal support for adhering blood platelets comprises the following steps: preparing a porous metal support by utilizing a 3D printing technology; preparing a three-dimensional micro stent inside the porous metal support by adopting a thermo-crosslinking method; and finally, performing freeze-drying on blood platelet-enriched plasma to be adhered to the three-dimensional micro stent. The composite porous metal support for adhering blood platelets provides the best growth microenvironment for growth of bone cells, cell factors can be slowly activated and released after the blood platelets subjected to freeze-drying treatment are hydrated, formation of bone tissues, fibrous tissues and new vessels is induced, and a good support material with biological activity is provided for clinical bone tissue repair.

Description

technical field [0001] The utility model belongs to the technical field of biomedical materials, and relates to a 3D printed medical porous metal bracket with a bionic three-dimensional micro-stent, in particular to a porous metal bracket with a platelet layer attached to the surface of the three-dimensional micro-stent to make it biologically active. Background technique [0002] As one of the biomedical metal functional materials, titanium alloy is widely used in human surgical implants, such as oral implants, bone defect repair materials, and pseudo-joint implants. It is non-toxic, lightweight, good biocompatibility and corrosion resistance, and has an elastic modulus that better matches that of human cortical bone. However, due to the biological inertness of the titanium alloy surface, it is not conducive to the growth of osteoblasts, so porous and surface coating modified titanium alloy scaffolds have received more and more attention. However, the existing mechanical p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/06A61L27/24A61L27/54A61L27/56B22F3/105B33Y10/00
CPCY02P10/25
Inventor 朱威吴志宏翁习生刘健许海燕尹博吴贵
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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