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Dai medicinal compound extract for preventing and treating Alzheimer disease and application of Dai medicinal compound extract

A technology for Alzheimer's disease and extracts, applied in the field of Dai medicine compound extracts and Dai medicine compound extracts for the prevention and treatment of Alzheimer's disease, which can solve the problem that the application of Alzheimer's disease has not been reported. , to achieve the effect of less toxic and side effects, low price and good curative effect

Inactive Publication Date: 2015-07-22
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the application of this Dai medicine group in the prevention and treatment of Alzheimer's disease has not been reported

Method used

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  • Dai medicinal compound extract for preventing and treating Alzheimer disease and application of Dai medicinal compound extract
  • Dai medicinal compound extract for preventing and treating Alzheimer disease and application of Dai medicinal compound extract
  • Dai medicinal compound extract for preventing and treating Alzheimer disease and application of Dai medicinal compound extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Preparation of Dai medicine compound extract

[0031] 1. Accurately weigh the following raw materials: 4 parts of Elderberry, 4 parts of Ganoderma lucidum, 2 parts of Tengzi, 2 parts of Manjusri, 1 part of Echinacea, and 1 part of Melissa.

[0032] 2. Preparation method: mix and pulverize ten kinds of medicinal materials such as ginseng, pass through No. 2 sieve of the Pharmacopoeia, add 70% ethanol with 10 times the quality of medicinal materials, heat and reflux for extraction once, each time for 1 hour, combine the extracts, concentrate under reduced pressure (70 ℃) to obtain a relative density of 1.15 extract, dilute the extract with 5 times the mass of water, mix it with an equal volume of D-101 macroporous adsorption resin, and put the sample on the D-101 macroporous adsorption resin column , the amount of loading is 20 times the ratio of the amount of extract to the amount of resin, static adsorption for 30 minutes, and then sequentially carried out wit...

Embodiment 2

[0033] Example 2 Preparation of Dai medicine compound extract

[0034] 1. Accurately weigh the following raw materials: 5 parts of Elderberry, 5 parts of Ganoderma lucidum, 3 parts of Tengzi, 3 parts of Manjusri, 2 parts of Echinacea, and 2 parts of Melissa.

[0035] 2. Preparation method: mix and pulverize ten kinds of medicinal materials such as ginseng, pass through No. 2 sieve of the Pharmacopoeia, add 70% ethanol with 20 times the quality of medicinal materials, heat and reflux extraction twice, each time for 1 hour, combine the extracts, concentrate under reduced pressure (60 ℃) to obtain the extract with a relative density of 1.20, dilute the extract with 5 times the mass of water, mix it with an equal volume of D-101 macroporous adsorption resin, and put the sample on the D-101 macroporous adsorption resin column , the amount of sample loading is 30 times the ratio of the amount of extract to the amount of resin, static adsorption for 30 minutes, and then sequentially ...

Embodiment 3

[0036] Example 3 Preparation of Dai medicine compound extract

[0037] 1. Accurately weigh the following raw materials: 6 parts of Elderberry, 6 parts of Ganoderma lucidum, 4 parts of Tengzi, 4 parts of Manjusri, 3 parts of Eucalyptus japonica, and 3 parts of Melissa.

[0038] 2. Preparation method: mix and pulverize ten kinds of medicinal materials such as ginseng, pass through No. 2 sieve of the Pharmacopoeia, add 70% ethanol with 30 times the quality of medicinal materials, heat and reflux extraction for 3 times, each time for 1 hour, combine the extracts, concentrate under reduced pressure (50 ℃) to obtain the extract with a relative density of 1.5, dilute the extract with 5 times the mass of water, mix it with an equal volume of D-101 macroporous adsorption resin, and put the sample on the D-101 macroporous adsorption resin column , the amount of loading is 40 times the ratio of the amount of extract to the amount of resin, static adsorption for 30 minutes, then successiv...

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PUM

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Abstract

The invention discloses a Dai medicinal compound extract, which is processed and prepared from sambucus chinensis, entada phaseoloides, crinum asiaticum, flemingia macrophylla and iberis umbellate. The Dai medicinal compound extract can be used for preventing and treating Alzheimer disease. The invention further discloses application of the Dai medicinal compound extract in preparation of a healthcare product and a medicine for preventing and treating the Alzheimer disease. The Dai medicinal compound extract disclosed by the invention is good in curative effect, fewer in toxic and side effects, cheap in price, and suitable for wide popularization in clinic.

Description

technical field [0001] The invention belongs to the field of medical applications, and relates to a compound extract of Dai medicine, in particular to a compound extract of Dai medicine for preventing and treating Alzheimer's disease and its application. Background technique [0002] Alzheimer's Disease (AD, also known as senile dementia) is the most common neurodegenerative disease and the main cause of dementia so far. Among all dementia patients, up to 50%-60% are AD. AD is a typical age-related disease. Among the elderly aged 60-64, the incidence of AD is only less than 1%, but with age, the incidence is almost exponentially increasing. In Western countries Among them, the incidence rate of people over the age of 85 reaches as high as 24%-33%. From the representative data of developing countries, the patients suffering from dementia in these countries account for 60% or more of the world's total. AD is very common and an important public health problem. Statistics sh...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P25/28
Inventor 刘斌龙旭阳张雅杰张延武耿放王发善闫姝葛雅南熊辉胡中花顾婷张宁
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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