Application of a kind of bidirectionally transformed mycelia and its extract in the preparation of anti-helicobacter pylori drugs

An anti-Helicobacter pylori and mycelium technology, applied in the directions of antibacterial drugs, drug combinations, plant/algae/fungus/moss components, etc., can solve problems such as no reported anti-Helicobacter pylori, insignificant effects, etc.

Active Publication Date: 2018-11-09
HUNAN XINHUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] According to literature records, Hericium erinaceus mycelium has anti-Helicobacter pylori effect, but the effect is not obvious, and Artemisia annua is mainly used for sterilization and anti-dysentery, and there is no report of anti-Helicobacter pylori
In the existing reports, there is no use of traditional Chinese medicine as the medium of Hericium erinaceus, let alone the use of Artemisia annua as the medium for bidirectional biological transformation.

Method used

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  • Application of a kind of bidirectionally transformed mycelia and its extract in the preparation of anti-helicobacter pylori drugs
  • Application of a kind of bidirectionally transformed mycelia and its extract in the preparation of anti-helicobacter pylori drugs
  • Application of a kind of bidirectionally transformed mycelia and its extract in the preparation of anti-helicobacter pylori drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A biological double-transformation "mycelium" extract, the preparation method of which comprises the following steps:

[0029] (1) Take 650g of wheat bran, 150g of cornmeal, 50g of rice bran, and 250g of Chinese medicinal material Artemisia annua powder (Artemisia annua), mix well, add 687.5g of water and mix well, and obtain mycelium culture medium, and then bottle it , Sterilize, insert Hericium erinaceus, transform and culture the mycelium at 20-27°C for 30-40 days, take out the "mycelium" of biological bidirectional transformation, and dry it to obtain the "mycelium" of biological bidirectional transformation ;

[0030] (2) The above-mentioned biological two-way transformation mycelia is extracted with 50% ethanol solution for the first time, extracted for 1 hour, then extracted with 50% ethanol solution for the second time, extracted for 1 hour; in the two extractions, the weight of 50% ethanol It is 4 times of the weight of the bidirectionally transformed myceliu...

Embodiment 2

[0033] A biological double-transformation "mycelium" extract, the preparation method of which comprises the following steps:

[0034](1) Take 700g of wheat bran, 200g of cornmeal, 100g of rice bran, and 666.7g of Chinese herbal medicine Artemisia annua powder (Artemisia annua), mix well, add 1000g of water and mix well, and obtain mycelium culture medium, and then bottle it , Sterilize, insert Hericium erinaceus, transform and culture the mycelium at 20-27°C for 30-40 days, take out the "mycelium" of biological bidirectional transformation, and dry it to obtain the "mycelium" of biological bidirectional transformation ;

[0035] (2) The above-mentioned biological two-way transformation mycelium is extracted for the first time with 75% ethanol solution for 1.5 hours, and then extracted for the second time with 75% ethanol solution for 1.5 hours; in the two extractions, the weight of 75% ethanol It is 6 times of the weight of the bidirectionally transformed mycelia.

[0036] (...

Embodiment 3

[0038] A biological double-transformation "mycelium" extract, the preparation method of which comprises the following steps:

[0039] (1) Take 750g of wheat bran, 250g of cornmeal, 150g of rice bran, and 1,500g of Chinese medicinal material Artemisia annua powder (Artemisia annua), mix well, add 1,500g of water and mix well to obtain mycelium culture medium, and then bottle it, Sterilize, insert Hericium erinaceus, transform and culture mycelium at 20-27°C for 30-40 days, take out the "mycelium" of bidirectional biotransformation, and dry it to obtain the "mycelium" of bidirectional biotransformation;

[0040] (2) The above-mentioned biological two-way transformation mycelia is extracted with 90% ethanol solution for the first time, extracted for 2 hours, then extracted with 90% ethanol solution for the second time, extracted for 2 hours; in the two extractions, the weight of 90% ethanol It is 8 times of the weight of the bidirectionally transformed mycelia.

[0041] (3) The ...

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Abstract

The invention discloses a biological bidirectional-transformation mycelium culture medium, a biological bidirectional-transformation mycelium and a biological bidirectional-transformation mycelium extract. The biological bidirectional-transformation mycelium culture medium is prepared by adding traditional Chinese medicine substance sweet wormwood herb to a subsidiary agricultural product culture medium. The biological bidirectional-transformation mycelium is prepared by performing mycelium transformation culture on the culture medium. The biological bidirectional-transformation mycelium extract is obtained by utilizing a water extraction treatment. The biological bidirectional-transformation mycelium extract has an anti-helicobacter pylori function which is remarkably better than that of hericium exinaceus hypha or the sweet wormwood herb, and can be applied to preparation of anti-helicobacter pylori medicines.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and in particular relates to a biological bidirectional transformation "mycelium" (the quotation marks in the text indicate the specific reference to the mycelium) and the application of its extract in the preparation of anti-helicobacter pylori drugs. Background technique [0002] Helicobacter pylori, Helicobacter pylori, referred to as Hp, is a unipolar, multi-flagellated bacterium with blunt rounded ends and helical bends. It is 2.5-4.0 μm long and 0.5-1.0 μm wide. On the surface of gastric mucosal epithelial cells, it often presents a typical spiral or arc shape. When growing on solid media, in addition to the typical morphology, sometimes rod or spherical shapes can appear. Helicobacter pylori is a microaerophilic bacterium that requires 5-8% oxygen in the environment and cannot grow in the atmosphere or in an absolutely anaerobic environment. (CHEMTRON) Helicobacter pylori det...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/06A61K36/282A61P31/04A61P1/04
Inventor 何述金周代俊
Owner HUNAN XINHUI PHARMA
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