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Method for extracting high-purity oleuropein from jasminum grandiflorum

A technology of oleuropein and frangipani is applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., and can solve the problem of low content of oleuropein

Active Publication Date: 2015-06-24
承德医学院中药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem in the prior art that the content of oleuropein enriched from frangipani is not high, the present invention provides a method for extracting high-purity oleuropein from frangipani

Method used

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  • Method for extracting high-purity oleuropein from jasminum grandiflorum
  • Method for extracting high-purity oleuropein from jasminum grandiflorum

Examples

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Embodiment 1

[0164] Example 1: Extracting high-purity oleuropein from frangipani

[0165] The implementation steps of this embodiment are as follows:

[0166] A. Ethanol aqueous leaching

[0167] According to the weight ratio of frangipani flower buds to 60% ethanol aqueous solution by weight of 1:12, the dry frangipani flower bud raw materials with a water content of 2.0% by weight are soaked in ethanol aqueous solution at room temperature for 3 times, each time for 50h, The extracts obtained each time are filtered, the filtrates are combined, and then concentrated and dried at a temperature of 46°C to obtain frangipani extract M 1 ;

[0168] B. Macroporous resin column adsorption

[0169] Macroporous resin pretreatment: The XDA-16 macroporous resin sold by Xi'an Lanxiao Technology New Materials Co., Ltd. is soaked in 95% ethanol aqueous solution by weight for 22 hours, then wet-packed, and then used 95% ethanol by weight Elute with aqueous solution until the effluent is mixed with wate...

Embodiment 2

[0176] Example 2: Extracting high-purity oleuropein from frangipani

[0177] The implementation steps of this embodiment are as follows:

[0178] A. Ethanol aqueous leaching

[0179] According to the weight ratio of frangipani flower buds and 55% ethanol aqueous solution by weight of 1:11, the dry frangipani flower bud raw materials with a water content of 1.9% by weight are soaked in ethanol aqueous solution at room temperature for 3 times, each time for 47h, The extracts obtained each time are filtered, the filtrates are combined, and then concentrated and dried at a temperature of 49°C to obtain frangipani extract M 1 ;

[0180] B. Macroporous resin column adsorption

[0181] Macroporous resin pretreatment: The HPD-100 type macroporous resin sold by Cangzhou Baoen Adsorption Material Technology Co., Ltd. is soaked in 90% ethanol aqueous solution by weight for 25 hours, then wet-packed, and then used 90% ethanol aqueous solution by weight Elute until the effluent is mixe...

Embodiment 3

[0188] Example 3: Extracting high-purity oleuropein from frangipani

[0189] The implementation steps of this embodiment are as follows:

[0190] A. Ethanol aqueous leaching

[0191] According to the weight ratio of frangipani flower buds to 65% by weight ethanol aqueous solution of 10:1, the dry frangipani flower bud raw materials with a water content of 1.6% by weight are soaked in ethanol aqueous solution at room temperature for 4 times, each time for 46 hours, The extracts obtained each time are filtered, the filtrates are combined, and then concentrated and dried at a temperature of 50°C to obtain frangipani extract M 1 ;

[0192] B. Macroporous resin column adsorption

[0193] Macroporous resin pretreatment: XDA-1 type macroporous resin sold by Xi'an Lanxiao Technology New Materials Co., Ltd. is soaked in 92% ethanol aqueous solution by weight for 26 hours, then wet packed, and then used 92% ethanol by weight Elute with aqueous solution until the effluent is mixed wi...

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Abstract

The invention relates to a method for extracting high-purity oleuropein from jasminum grandiflorum. The method includes digestion of ethanol water, adsorption of a large-hole resin column and a polyamide column and preparation of oleuropein. Purity of the prepared oleuropein is up to 98.0-99.5% by weight, extraction rate of oleuropein is up to 2-4%, and the method is stable, good in reproducibility, convenient and very applicable to industrial production.

Description

【Technical field】 [0001] The invention belongs to the technical field of extraction of active ingredients of traditional Chinese medicines. More specifically, the present invention relates to a method for extracting high-purity oleuropein from frangipani. 【Background technique】 [0002] Jasminum officinale L.var.grandiflorum is the dried flower bud of Jasminum officinale L.var.grandiflorum, also known as Jasminum officinale L.var.grandiflorum. Our folks use it to treat indigestion, duodenal ulcer, chronic hepatitis, cirrhosis and other diseases. Jasmine is widely cultivated all over the world, and its resources are very rich. The research results show that Frangipani mainly contains iridoid glycosides, triterpenoid saponins and flavonoids, among which the content of iridoid glycosides oleuropein is relatively high, which has great research and development value. [0003] The molecular formula of oleuropein is C 25 h 32 o 13 , has a variety of biological activities, suc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/04C07H1/08
CPCC07H1/08C07H17/04
Inventor 赵桂琴尹志峰李洪波毛晓霞苏占辉
Owner 承德医学院中药研究所
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