Preparation method of glycosylated surfactant

A surfactant and sugar-based technology, applied in the field of preparation of sugar-based active agents, to achieve good application prospects, high surface activity and environmental friendliness

Inactive Publication Date: 2015-06-24
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are various kinds of sugar-based surfactants, but they cannot meet the needs of various industries. Therefore, it is urgent to synthesize a kind of surfactants with mild reaction conditions and high surface activity.

Method used

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  • Preparation method of glycosylated surfactant
  • Preparation method of glycosylated surfactant
  • Preparation method of glycosylated surfactant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A kind of preparation method of sugar-based surfactant , including the following steps:

[0023] Step 1: Weigh 6g of glucose, dissolve it in 100mL of methanol at 60°C, then add octadecylamine to glucose molar ratio of 1:1, and stir and react with glucose at 60°C for 8h to prepare Get alkylglucosimine, then add excess NaBH 4 And stir at room temperature or under an ice-water bath until no bubbles are generated, and the crude product of alkyl glucosamine is obtained;

[0024] Step 2: washing the prepared crude alkylglucosamine with iced absolute ethanol and methanol, and suction filtering to obtain alkylglucosamine;

[0025] Step 3: Dissolve the prepared alkylglucosamine in 100mL of methanol at a temperature of 70°C, and then add glyoxylic acid to make it react with the alkyl Glucosamine was stirred and reacted at 70°C for 10 hours to obtain the crude sugar-based surfactant;

[0026] Step 4: Remove the reaction solvent and unreacted glyoxylic acid from the prepared cr...

Embodiment 2

[0029] A kind of preparation method of sugar-based surfactant , including the following steps:

[0030] Step 1: Weigh 6g of glucose, dissolve it in 100mL of methanol at 55°C, and then add hexadecylamine to the molar ratio of hexadecylamine to glucose at a ratio of 1:1 to make it react with glucose at 55°C for 8 hours to prepare Get alkylglucosimine, then add excess NaBH 4 And stir at room temperature or under an ice-water bath until no bubbles are generated, and the crude product of alkyl glucosamine is obtained;

[0031] Step 2: washing the prepared crude alkylglucosamine with iced absolute ethanol and methanol, and suction filtering to obtain alkylglucosamine;

[0032] Step 3: Dissolve the prepared alkylglucosamine in 100mL of methanol at a temperature of 60°C, and then add glyoxylic acid to make it react with the alkyl Glucosamine was stirred and reacted at 60°C for 10 hours to obtain the crude sugar-based surfactant;

[0033] Step 4: Remove the reaction solvent and unr...

Embodiment 3

[0035] A kind of preparation method of sugar-based surfactant , including the following steps:

[0036] Step 1: Weigh 6g of glucose, dissolve it in 100mL of methanol at 50°C, then add dodecylamine and glucose in a ratio of 1:1 molar ratio of dodecylamine to glucose, and stir and react with glucose for 8 hours at 50°C to prepare Get alkylglucosimine, then add excess NaBH 4 And stir at room temperature or under an ice-water bath until no bubbles are generated, and the crude product of alkyl glucosamine is obtained;

[0037] Step 2: washing the prepared crude alkylglucosamine with iced absolute ethanol and methanol, and suction filtering to obtain alkylglucosamine;

[0038] Step 3: Dissolve the prepared alkylglucosamine in 100mL of methanol at a temperature of 60°C, and then add glyoxylic acid to make it react with the alkyl Glucosamine was stirred and reacted at 60°C for 10 hours to obtain the crude sugar-based surfactant;

[0039] Step 4: Remove the reaction solvent and unr...

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Abstract

The invention relates to a preparation method of a glycosylated surfactant. The preparation method comprises the following steps: firstly weighing glucose, dissolving the glucose in a methanol solution, then adding long-chain n-alkylamine according to the molar ratio of long-chain n-alkylamine to glucose of (1:1)-(1:6) to react with glucose to prepare alkyl glucosimine, then adding an excessive amount of NaBH4 to perform reaction to prepare an alkyl glycosamine crude product; sequentially washing the crude product with iced anhydrous ethanol and methanol solutions, and performing suction filtration to obtain alkyl glycosamine; further dissolving prepared alkyl glycosamine in the methanol solution, then adding glyoxylic acid according to the molar ratio of glyoxylic acid to alkyl glycosamine of (2:1)-(6:1) to react with alkyl glycosamine so as to prepare a glycosylated surfactant crude product; removing a reaction solvent and unreacted glyoxylic acid in the crude product by a rotating evaporation instrument to obtain the glycosylated surfactant. According to the preparation method provided by the invention, the novel glycosylated surfactant is prepared by reaction of glyoxylic acid and self-made alkyl glycosamine.

Description

technical field [0001] The invention relates to the technical field of fine chemicals, in particular to a preparation method of a glycosyl-type active agent. Background technique [0002] Sugar-based surfactants not only have good surface activity, but also use natural glucose as raw material, which is easy to biodegrade, mild to the human body, and non-polluting to the environment. Therefore, the synthesis and performance of sugar-based surfactants Research has received extensive attention in recent years. [0003] At present, there are various types of sugar-based surfactants, but they cannot meet the needs of various industries. Therefore, it is urgent to synthesize a kind of surfactants with mild reaction conditions and high surface activity. Contents of the invention [0004] In order to enrich the types of surfactants, the object of the present invention is to provide a method for preparing a sugar-based surfactant, so as to realize the synthesis of a sugar-based su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/04C07C229/12B01F17/28B01F17/38C09K23/28C09K23/38
Inventor 任龙芳惠林涛王学川强涛涛
Owner SHAANXI UNIV OF SCI & TECH
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