Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Absorbable orthopedic internal fixation material based on silk fibroin and preparation method thereof

A technology for fixing materials and silk fibroin, which is applied in the field of materials, can solve the problems of affecting local wound healing, sinus formation, lack of product mechanical strength, poor mechanical strength, etc., achieve superior mechanical strength, facilitate implantation, and reduce stress The effect of occlusion

Inactive Publication Date: 2015-06-17
GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
View PDF5 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] With the rapid development of materials science, various absorbable materials have emerged and are rapidly applied in fracture internal fixation systems, including materials such as PLGA, PGA, and silk fibroin materials that have recently appeared. Among these materials, due to PLA / PGA can produce an acidic substance during the degradation process, thereby affecting local wound healing and sinus formation, and its mechanical strength is not good, so it is only used for non-weight-bearing bones at present, while silk fibroin material has good biocompatibility and is inflammatory It has little reaction and can be sterilized by autoclaving. It has been widely used in surgical operations, such as sutures, silk membranes and scaffold materials used in surgery. Because the traditional method of extracting silk fibroin is time-consuming and the resulting product is The mechanical strength is still lacking, so traditional silk fibroin is still not widely used in orthopedic internal fixation systems

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Absorbable orthopedic internal fixation material based on silk fibroin and preparation method thereof
  • Absorbable orthopedic internal fixation material based on silk fibroin and preparation method thereof
  • Absorbable orthopedic internal fixation material based on silk fibroin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of preparation method of the absorbable orthopedic internal fixation material based on silk fibroin of the present invention comprises the following steps:

[0025] 1. Measure 5000mL deionized water, add Na after boiling 2 CO 3 3g and stir evenly, add 100g of raw silk according to the bath ratio of 1:50 (w:v), boil for 30min for degumming.

[0026] 2. After degumming, clean it with deionized water, repeat 3 times, and place the degummed silk in an oven at 60°C to dry for later use.

[0027] 3. Weigh the degummed silk obtained in step 2 and add the ternary solution CaCl with a bath ratio of 1:10 2 ·CH 3 CH 2 OH·H 2 O (molar ratio 1:2:8), under the action of a water bath at 80-90°C until the silk is completely dissolved to obtain a silk fibroin solution.

[0028] The specific operation is: add 200g CaCl to 260ml ultrapure water 2 After completely dissolving, add 208ml of ethanol and 50g of degummed silk, and heat in a water-soluble pot at 80-90°C. In this o...

Embodiment 2

[0043] Except that in step 1, raw silk is added according to bath: 1: 100 (w: v), other operations are the same as in Example 1. The mechanical properties of the materials obtained in this embodiment are shown in Table 4-6.

[0044] Table 4 Performance parameters of three-point bending products

[0045]

[0046] Table 5 Performance parameters of compression mechanics test

[0047]

[0048] The performance parameter of table 6 tensile mechanics test

[0049]

[0050] Co-cultivation of the material prepared in this example with MC3T3 cells showed that the cells grew well and had normal morphology, indicating that the material had better biocompatibility.

Embodiment 3

[0052] In addition to step 3, the silk fiber was added to the ternary solution CaCl at a bath ratio of 1:50 2 ·CH 3 CH 2 OH·H 2 0, all the other operations are the same as in Example 1. The mechanical properties of the materials obtained in this embodiment are shown in Table 7-9.

[0053] Table 7 Performance parameters of three-point bending products

[0054]

[0055] Table 8 Performance parameters of compression mechanics test

[0056]

[0057] Co-cultivation of the material prepared in this example with MC3T3 cells showed that the cells grew well and had normal morphology, indicating that the material had better biocompatibility.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an absorbable orthopedic internal fixation material based on silk fibroin and a preparation method thereof. By changing the environment temperature and changing the mass-to-volume ratio of the silk fibroin, the prepared absorbable orthopedic internal fixation material based on silk fibroin is more excellent in mechanical strength, good in biocompatibility, little in inflammatory reaction and convenient to implant, can realize autoclaved sterilization and fixation maintaining for 4-8 weeks, can reduce the stress shielding to the maximum extent, and has a wide application prospect.

Description

technical field [0001] The invention belongs to the field of materials, and in particular relates to a preparation method of an absorbable orthopedic internal fixation material based on silk fibroin. Background technique [0002] With the rapid development of materials science, various absorbable materials have emerged and are rapidly applied in fracture internal fixation systems, including materials such as PLGA, PGA, and silk fibroin materials that have recently appeared. Among these materials, due to PLA / PGA can produce an acidic substance during the degradation process, which will affect local wound healing and sinus formation, and its mechanical strength is not good. Therefore, it is only used for non-weight-bearing bones at present, while silk fibroin material has good biocompatibility and is inflammatory. It has low reaction and can be sterilized by autoclaving. It has been widely used in surgical operations, such as sutures, silk membranes and scaffold materials use...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14
Inventor 蒲小兵夏虹尹庆水郑冠康洁李炳玲张余张涛
Owner GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com