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Isotopic tracing method for monitoring cancer cell osseous metastasis

An isotope tracing, bone metastasis technology, applied in the field of nuclear technology application, can solve the problems of difficult to achieve early detection of cancer cell bone metastasis, low sensitivity, etc., to achieve the effect of early detection time and improved survival rate

Active Publication Date: 2015-06-10
GUANGXI NORMAL UNIV
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Problems solved by technology

The invention solves the problem that the sensitivity of the existing monitoring means is relatively low and it is difficult to realize the early monitoring of cancer cell bone metastasis

Method used

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  • Isotopic tracing method for monitoring cancer cell osseous metastasis
  • Isotopic tracing method for monitoring cancer cell osseous metastasis
  • Isotopic tracing method for monitoring cancer cell osseous metastasis

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Embodiment Construction

[0054] The principles and features of the present invention will be described below in conjunction with specific drawings, and the examples given are only used to explain the present invention, not to limit the scope of the present invention.

[0055] Such as figure 1 Shown, the implementation process of the present invention is:

[0056] (1) 41 Generation of Ca-labeled tracers: Take 1g of the abundance>99% 40 CaCO 3 , into a quartz bottle, and irradiated on the heavy water reactor (CARR) of the China Institute of Atomic Energy for 100 hours. The thermal neutron flux of the reactor is (5.0±0.5)×10 14 piece / s·cm 2 , the specific activity after irradiation is (5.0±0.2)×10 6 Bq / g, ie 41 Ca and 40 The atomic number ratio of Ca is about 7:10 5 ,get 41 CaCO 3 , and then dissolved in 10ml of 36% w / w concentrated HCl solution to generate 41 CaCl 2 solution, that is 41 Ca-labeled tracer;

[0057] (2) use 41 Ca-labeled tracer-labeled experimental nude mice: the experiment...

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Abstract

The invention discloses an isotopic tracing method for monitoring cancer cell osseous metastasis. The method refers to a measurement method by taking 41Ca as a tracer agent and taking accelerator mass spectrometry (AMS) as a tracer agent and is used for monitoring the occurrence, development and resolution processes of the cancer cell osseous metastasis, and belongs to the technical field of nuclear technologies. The method disclosed by the invention comprises the following steps: (1) generating a 41Ca marked tracer agent; (2) marking an experimental nude mouse by using the 41Ca marked tracer agent; (3) collecting a urine sample of the nude mouse in the step (2), and separating the element Ca; (4) measuring the 41Ca / 40Ca isotope abundance ratio in the calcium fluoride powder obtained in the step (3); and (5) drawing a standard curve; and (6) analyzing the difference, so as to obtain the cancer cell osseous metastasis degree. According to the method disclosed by the invention, the problems that the sensitivity of a conventional monitoring means is relatively low and the early monitoring of the cancer cell osseous metastasis is difficultly realized are solved, and the method has high clinical application values and social benefits.

Description

technical field [0001] The present invention relates to an isotope tracer method for monitoring cancer cell bone metastasis, specifically, it is based on 41 Ca is a tracer, and the measurement method using accelerator mass spectrometry (AMS) as a tracer is used to monitor the occurrence, development and regression process of cancer cell bone metastasis, which belongs to the application field of nuclear technology. Background technique [0002] In the past 30 years, cancer research all over the world has gone deep into basic and clinical fields, and a consensus has been gradually reached on the multidisciplinary comprehensive treatment of various cancers. However, the 5-year survival rate of cancer patients is still stagnating and encountering bottlenecks. The important reasons are Is the cancer prone to distant spread. When distant metastases occur in cancer patients, nearly 60% are bone metastasis, and about 30% of them are asymptomatic. Bone metastasis is a common and fa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62A61K51/00
Inventor 沈洪涛姜山何明董克君庞芳芳史颜君夏春波刘曼君
Owner GUANGXI NORMAL UNIV
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