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5alpha-reductase inhibitor and application thereof

A kind of reductase, inhibition technology, applied in lychee shell extract and its application in personal care products

Inactive Publication Date: 2015-06-03
SHANGHAI JAHWA UNITED +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the inhibitory effect of litchi shell on 5α-reductase

Method used

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  • 5alpha-reductase inhibitor and application thereof
  • 5alpha-reductase inhibitor and application thereof
  • 5alpha-reductase inhibitor and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: the extraction of litchi shell

[0031] Add 8 times the amount of 30% ethanol to 50 g of litchi shells, heat and reflux for extraction for 1 hour, and filter. Take the filtrate, recover ethanol under reduced pressure and dry to obtain litchi shell extract.

Embodiment 2

[0032] Example 2: Inhibitory effect of litchi shell extract on 5α-reductase

[0033] The litchi shell extract prepared in Example 1 was dissolved and diluted into 5 concentration gradients with 45% (v / v) DMSO (Tris buffer 55%): 3.4% by weight, 1.7% by weight, 0.85% by weight, 0.43% by weight, 0.21% by weight. 5α-reductase inhibition experiments were performed as described below. The reaction system of the experimental platform is 1ml, and the sample additive amount is 0.1ml, so the initial concentration starts from 0.34% by weight of the crude drug, and the system concentrations are: 0.34% by weight, 0.17% by weight, 0.085% by weight, 0.043% by weight, and 0.021% by weight ; Because the system contains 4.5% (v / v) DMSO, so the 4.5% (v / v) DMSO solvent control is set simultaneously, and the dutasteride of 1mg / L is a positive control.

[0034] 5α-reductase experimental platform

[0035] The enzyme was extracted from the liver of SD rats and stored frozen for later use; the enzy...

Embodiment 3

[0039] Example 3: Preparation of oil-controlling skin care water containing litchi shell extract

[0040] According to the ingredients and dosage in Table 1, the oil-control skin care water containing the lychee shell extract of the present invention was prepared.

[0041] Table 1

[0042] Element

[0043] Phase B

[0044] Preparation method: Weigh the three phases A, B, and C according to the above proportions, stir each one evenly, slowly add phase B to phase A while stirring, add phase C after stirring, stir and dissolve evenly to obtain the finished oil control skin care water.

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Abstract

Provided are uses of lychee skin extract as a 5α-reductase inhibitor: use of lychee skin extract as a 5α-reductase inhibitor in preparation of personal care products having sebum balancing and anti-acne efficacy, and use of lychee skin extract as a 5α-reductase inhibitor in preparation of personal care products having hair loss prevention efficacy.

Description

technical field [0001] The invention relates to a traditional Chinese medicine with 5α-reductase inhibitory effect and its application in personal care products, in particular to litchi shell extract and its application in personal care products. Background technique [0002] Acne and alopecia are common chronic diseases in clinic and occur in a wide range of people. Although acne and alopecia are not life-threatening, they often cause serious mental burden to patients. With the increasingly fierce competition in today's society and the deterioration of the living environment, the incidence of acne and hair loss has been on the rise in recent years, but effective products for acne and hair loss are still relatively scarce. [0003] There are many factors that cause acne and hair loss, but modern medicine believes that local androgen metabolism abnormalities may be the main cause of disease. Because excessive androgen can lead to increased volume of sebaceous glands and incr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61Q19/10A61Q19/00A61Q5/02A61Q5/12A61P17/10A61P17/08A61P17/14
CPCA61K8/9789A61K2800/782A61P17/08A61P17/10A61P17/14A61Q7/00
Inventor 卢玲巧祝乐赵亚向胜习吕洛戴竟
Owner SHANGHAI JAHWA UNITED
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