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Teat sealant for preventing dry mastitis in dairy cows and preparation method thereof

A teat sealant and technology for dry period, which is applied in the field of teat sealant and its preparation for preventing dry period mastitis of dairy cows, can solve problems such as breast heat and pain, increase of milk somatic cells, etc., and achieve improvement of cure rate, Good therapeutic effect, the effect of alleviating inflammation

Active Publication Date: 2017-12-19
QILU ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problem that the existing teat sealant combined with antibiotics causes inflammatory pathological reactions such as breast heat and pain, swelling, and increased milk somatic cells and has a low cure rate, the present invention provides a method for preventing mastitis in the dry period of dairy cows. Teat sealant and method for its preparation

Method used

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  • Teat sealant for preventing dry mastitis in dairy cows and preparation method thereof
  • Teat sealant for preventing dry mastitis in dairy cows and preparation method thereof
  • Teat sealant for preventing dry mastitis in dairy cows and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1) Micronize bismuth subnitrate and geniposide separately, until the particle size is not greater than 25 microns (μm);

[0026] 2) Put 26.43g of liquid paraffin into a 250ml beaker, raise the temperature to 140°C, add 2.5g of aluminum stearate, 1.0g of silicon dioxide, 0.05g of 2,6-di-tert-butyl-p-cresol, and o-phenyl Phenol 0.02g, heated and stirred until completely dissolved to make it into a gel matrix, and cooled in a cold water bath to below 40°C;

[0027] 3) Take 5.0 g of the geniposide treated with micronization in step 1) and place it in the gel matrix, disperse it by ultrasonic, and homogenize it in a high-shear dispersing homogenizer for 10 minutes;

[0028] 4) Add 20.0g bismuth subnitrate in batches, add 2.0g in each batch, stir while adding, continue stirring for 20min after adding the 20.0g bismuth subnitrate; then add 45.0g bismuth subnitrate in batches, each time Add 2.0g, stir while adding, and continue stirring for 20 minutes after the addition is com...

Embodiment 2

[0031] 1) Micronize bismuth subnitrate and geniposide separately, until the particle size is not greater than 25 microns (μm);

[0032] 2) Put 39.93g of liquid paraffin into a 250ml beaker, raise the temperature to 140°C, add 4.0g of aluminum stearate, 1.0g of silicon dioxide, 0.05g of 2,6-di-tert-butyl-p-cresol, and o-phenyl Phenol 0.02g, heated and stirred until completely dissolved to make it into a gel matrix, and cooled in a cold water bath to below 40°C;

[0033] 3) Take 5.0 g of the geniposide treated with micronization in step 1) and place it in the gel matrix, disperse it by ultrasonic, and homogenize it in a high-shear dispersing homogenizer for 10 minutes;

[0034] 4) Add 15.0g bismuth subnitrate in batches, add 1.5g in each batch, stir while adding, continue stirring for 20min after adding the 15.0g bismuth subnitrate; then add 35.0g bismuth subnitrate in batches, each time Add 2.0g, stir while adding, and continue stirring for 20 minutes after the addition is com...

Embodiment 3

[0037] 1) Micronize bismuth subnitrate and geniposide separately, until the particle size is not greater than 25 microns (μm);

[0038] 2) Put 17.43g of liquid paraffin into a 250ml beaker, raise the temperature to 140°C, add 1.5g of aluminum stearate, 1.0g of silicon dioxide, 0.05g of 2,6-di-tert-butyl-p-cresol, and o-phenyl Phenol 0.02g, heated and stirred until completely dissolved to make it into a gel matrix, and cooled in a cold water bath to below 40°C;

[0039] 3) Take 5.0 g of the geniposide treated with micronization in step 1) and place it in the gel matrix, disperse it by ultrasonic, and homogenize it in a high-shear dispersing homogenizer for 10 minutes;

[0040] 4) Add 25.0g bismuth subnitrate in batches, add 2.5g in each batch, stir while adding, continue stirring for 20min after adding the 25.0g bismuth subnitrate; then add 50.0g bismuth subnitrate in batches, each time Add 2.5g, stir while adding, and keep stirring for 20 minutes after the addition is complet...

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Abstract

The invention discloses a teat sealant for preventing dry mastitis of dairy cows and a preparation method thereof, belonging to the field of veterinary medicine. The teat sealant of the present invention is composed of 40wt%-75wt% non-toxic metal compound, 2wt%-10wt% geniposide and 10wt%-50wt% gel matrix; wherein the gel matrix consists of 70 wt%-90 wt% dispersion medium, 5 wt%-12 wt% gelling agent, 2 wt%-5 wt% suspending agent, 0.1 wt%-0.3 wt% antioxidant and 0.04 wt%- 0.15 wt% preservative composition. The active ingredient geniposide in the teat sealant of the present invention cooperates with the non-toxic metal compound, which has a high cure rate for mastitis in dry milk cows and effectively alleviates the inflammatory response of clinical mastitis.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a teat sealant for preventing dry mastitis in dairy cows and a preparation method thereof. Background technique [0002] Mastitis is a common and frequently-occurring disease of dairy cows and one of the most important diseases affecting the development of the dairy industry. It not only reduces the amount of milk produced and the quality of dairy products, but even causes damage to the udder, causing huge economic losses to the dairy industry. At present, there are about 220 million dairy cows in the world, 1 / 3 of which suffer from various types of mastitis, and the annual loss due to mastitis is as high as 35 billion U.S. dollars, and the loss in the United States alone reaches 2 billion U.S. dollars. According to 30 years of investigation and research data, the average detection rate of mastitis in dairy cows in my country is 50% to 70%, and the average positive ra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/30A61K33/24A61K31/7048A61K9/06A61P15/14A61P31/04
Inventor 王海挺张智德刘金华孔梅吴连勇王甜
Owner QILU ANIMAL HEALTH PROD
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