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Quality stability control method for Chinese prescription particle extraction process

A technology of traditional Chinese medicine formula granules and quality stability, which is applied in non-electric variable control, control/regulation system, and simultaneous control of multiple variables, etc., can solve the problems of incomplete extraction of active ingredients, long extraction time, uneven temperature, etc. Achieve the effect of ensuring process and quality stability, high content of active ingredients, and overcoming quality instability

Active Publication Date: 2015-05-20
ANHUI CHINA RESOURCES JINCHAN PHARMA CO LTD
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AI Technical Summary

Problems solved by technology

The extraction temperature affects the dissolution rate of the active ingredients. If the temperature is too low, the extraction of the active ingredients will be incomplete, resulting in unqualified final products; if the temperature is too high, it may cause the decomposition of heat-sensitive ingredients, and may even lead to the dissolution of the drug. The liquid is fried, which will eventually lead to unqualified products
However, most of the current Chinese medicine extraction tanks have the problem of uneven temperature in the tank, which leads to long extraction time, poor extraction effect, low heat exchange efficiency, high energy consumption, and even seriously affects the quality of the product.

Method used

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  • Quality stability control method for Chinese prescription particle extraction process
  • Quality stability control method for Chinese prescription particle extraction process
  • Quality stability control method for Chinese prescription particle extraction process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 100 Kg of honeysuckle decoction pieces and add 800 Kg of water to soak for 30 minutes, heat to boil and keep boiling for 2 hours. Heating is carried out through the extraction tank double-layer jacket segmental heating and tank bottom heating technology. After heating for 15 minutes, the extract boils. Real-time monitoring of the temperature and pressure in the extraction tank, the steam flow rate and the temperature of the cooling water entering and leaving the condenser, the design temperature difference between the cooling water entering and exiting is 12~18°C, the temperature setting in the tank is 96~102°C, and the pressure is 0~0.02 MPa. Arrange 6 temperature probes in the tank, which are respectively distributed at the upper end, middle end and bottom of the extraction tank near the jacket and near the center line. Cooling water inlet and outlet temperature difference Δt and cooling water inlet and outlet speed v It has a certain functional relationship. W...

Embodiment 2

[0030] Take 100 Kg of Ligusticum chuanxiong and add 600 Kg of water to soak for 120 minutes, heat to boil and keep boiling for a few hours. The volatile oil of Rhizoma Chuanxiong is collected, and the oil-water interface detection technology is used for the oil-water separator to realize automatic oil-water separation. The oil-water interface detection technology can make the moisture content in the volatile oil lower than 3%. Get the obtained volatile oil and adopt gas chromatography to detect the moisture content in the volatile oil. The water content in the obtained volatile oil is shown in the table below.

[0031] Gas chromatography conditions: column: GDX101 column (3m × Φ4 mm); detector: thermal conductivity detector; injector temperature: 150 ~ 170 ℃; column temperature: 120 ~ 140 ℃; detector temperature: 140 ~160℃; carrier gas: helium; carrier gas flow: 40 ~ 50 mL / min.

[0032]

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Abstract

The invention discloses a quality stability control method for a Chinese prescription particle extraction process. A segmented heating technology for a double-layer jacket of an extraction tank and a tank bottom heating technology are adopted for controlling; a cooperative control way concerned with temperature, pressure, cooling water flow and steam flow is adopted, the steam input amount and cooling water flow are adjusted in real time, and the temperature fluctuation in the extraction tank is reduced; automatic oil-water separation is realized through an oil-water interface detection technology in an oil-water separator. The quality stability control method is applied to the extraction process of Chinese prescription particles, the temperature rising speed is not lower than 4 DEG C per minute, the temperature fluctuation of the extraction tank in the extraction process is lower than 3 percent, the obtained extracting solution has high liquid yield, high solid content and high effective component content, the batch difference is lower than 5 percent, the process and quality stability of the extraction process are ensured, and the problem of instable quality in the conventional extraction process is solved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine pharmacy, in particular to a method for controlling the quality stability of the extraction process of traditional Chinese medicine formula granules. Background technique [0002] The pharmaceutical process of traditional Chinese medicine formula granules generally includes: pretreatment of medicinal materials (harvesting-washing-drying)-extraction-separation-purification-(crushing)-screening analysis-mixing-granulation. The extraction process is an important link in the production of traditional Chinese medicine formula granules, and plays a vital role in the safety, effectiveness, and stability of the final product. Extraction is the process of dissolving the active ingredients in traditional Chinese medicine from plant tissues with an appropriate solvent. The extraction temperature affects the dissolution rate of the active ingredients. If the temperature is too low, the extraction ...

Claims

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Application Information

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IPC IPC(8): G05D27/02B01D11/02
Inventor 高波罗川
Owner ANHUI CHINA RESOURCES JINCHAN PHARMA CO LTD
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