Starch-based hemostasis sponge and preparation method of hemostasis sponge

Abstract

The invention relates to a medical hemostasis instrument and in particular relates to a starch-based hemostasis sponge and a preparation method of the hemostasis sponge. The starch-based hemostasis sponge is prepared from the following raw materials in parts by weight: 80-95 parts of starch, 2-10 parts of hydroxypropyl methylcellulose calcium, 2-5 parts of a cross-linking agent and 1-5 parts of a plasticizer. The preparation method of the hemostasis sponge comprises the following steps: step one, crosslinking starch with hydroxypropyl methylcellulose calcium by virtue of the cross-linking agent; step two, purifying; and step three, freeze-drying and sterilizing to prepare the finished starch-based hemostasis sponge. According to the starch-based hemostasis sponge and the preparation method of the hemostasis sponge, the hemostasis sponge is prepared by crosslinking starch with hydroxypropyl methylcellulose calcium; the hydroxypropyl methylcellulose calcium is high in water absorption rate, excellent in formability, high in strength and not liable to break, and has a plurality of functions of stopping bleeding, packing and repairing.

Description

technical field [0001] The invention relates to a medical hemostatic appliance, in particular to a starch-based hemostatic sponge and a preparation method thereof. Background technique [0002] Hemostatic sponge plays an important role in the hemostasis, filling and repair of wounds, surgical tissue wounds and defective tissues. There are mainly four kinds of hemostatic sponges that are commercialized now: gelatin hemostatic sponge, collagen hemostatic sponge, chitosan hemostatic sponge, and PVF hemostatic sponge. [0003] The disadvantages of gelatin hemostatic sponge are: gelatin is derived from pig bone or bovine bone, which can cause allergic reactions, there is also the risk of mad cow disease, and the water absorption rate is low; [0004] The disadvantages of collagen hemostatic sponge are: collagen is derived from animal bones, causing allergic reactions, and there is a risk of mad cow disease, and the price is expensive; [0005] The disadvantages of chitosan hemo...

AI Technical Summary

Problems solved by technology

[0003] The disadvantages of gelatin hemostatic sponge are: gelatin is derived from pig bone or bovine bone, causing allergic reactions, and there is a risk of mad cow disease, and the water absorption rate is low;

[0004] The disadvantages of collagen hemostatic sponge are: collagen is derived from animal bones, causing allergic reactions, and there is a risk of mad cow disease, and the price is expensive;

[0005] The disadvantages of chitosan hemostatic sponge are: slow absorption and high price;

[0006] The disadvantages of PVF hemostatic sponge are: formaldehyde is toxic and expensive

The common disadvantages of these patents are that the water absorption rate is not high, the molding performance is poor, the strength is low and brittle, and even the starch granules may fall off from the sponge, which seriously affects the application.

[0009] In addition, there are 2 patents on the preparation of starch foam with starch as raw material. Patent CN101003646A discloses a production method of foamable biomaterials and biofoam products. The preparation method is screw extrusion and calendering into pipes or plates. , very low water absorption, not spongy, can not be used as a hemostatic sponge

CN1439033A discloses a kind of starch foam body, and its preparation method is screw extruding, is prepared into film or sheet material, and water absorption rate is very low, is not spongy, can not be used as hemostatic sponge