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Bioconversion mycelium and application of bioconversion mycelium extract in preparation of anticoagulant drugs

A technology of biotransformation and mycelium, applied in biochemical equipment and methods, methods based on microorganisms, microorganisms, etc., can solve the problems of preservation conditions that damage enzyme active substances, and the effect is not obvious

Active Publication Date: 2015-05-13
HUNAN XINHUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] According to literature records, Hericium erinaceus mycelium has anticoagulant effect, but the effect is not obvious, and many anticoagulant active substances of earthworm are enzymes. Both the process and the storage conditions have greatly damaged the enzyme activity in it.

Method used

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  • Bioconversion mycelium and application of bioconversion mycelium extract in preparation of anticoagulant drugs
  • Bioconversion mycelium and application of bioconversion mycelium extract in preparation of anticoagulant drugs
  • Bioconversion mycelium and application of bioconversion mycelium extract in preparation of anticoagulant drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A biotransformation "mycelia" extract, the preparation method of which comprises the following steps:

[0027] (1) Take 650g of wheat bran, 150g of cornmeal, 70g of rice bran, 8g of white sugar, and 250g of Chinese herbal medicine Dilong powder (Dilong), mix well, add 687.5g of water and mix well, and obtain the mycelium culture medium. Then bottle, sterilize, insert Hericium erinaceus, transform and culture mycelium at 20-27°C for 30-40 days, take out the biotransformation "mycelium" and dry it to obtain the biotransformation "mycelium" ";

[0028] (2) Take the biotransformation "mycelia" and carry out the first water normal temperature flash extraction for 15 minutes, then perform the second water normal temperature flash extraction for 15 minutes; the first water normal temperature flash extraction , the weight of water is 4 times of the weight of the biotransformation "mycelium"; in the second water normal temperature flash extraction, the weight of water is 2 time...

Embodiment 2

[0031] A biotransformation "mycelia" extract, the preparation method of which comprises the following steps:

[0032](1) Take 700g of wheat bran, 200g of cornmeal, 90g of rice bran, 10g of white sugar, and 666.7g of Chinese herbal medicine Dilong powder (Dilong), mix well, add 1000g of water and mix well, and obtain the mycelium culture medium. Then bottle, sterilize, insert Hericium erinaceus, transform and culture mycelium at 20-27°C for 30-40 days, take out the biotransformation "mycelium" and dry it to obtain the biotransformation "mycelium" ";

[0033] (2) Take the biotransformation "mycelium", carry out the first water normal temperature flash extraction for 20 minutes, then perform the second water normal temperature flash extraction for 20 minutes; the first water normal temperature flash extraction , the weight of water is 5 times of the weight of the biotransformation "mycelium"; in the second water normal temperature flash extraction, the weight of water is 3 times...

Embodiment 3

[0036] A biotransformation "mycelia" extract, the preparation method of which comprises the following steps:

[0037] (1) Take 750g of wheat bran, 250g of cornmeal, 110g of rice bran, 12g of white sugar, and 1500g of Chinese herbal medicine Dilong powder (Dilong), mix well, add 1500g of water and mix well, and obtain the mycelium culture medium. Bottling, sterilizing, inserting Hericium erinaceus, transforming and culturing the mycelium at 20-27°C for 30-40 days, taking out the biotransformation "mycelium" and drying it to obtain the biotransformation "mycelium" ;

[0038] (2) Take the biotransformation "mycelia" and carry out the first water normal temperature flash extraction for 25 minutes, then perform the second water normal temperature flash extraction for 25 minutes; the first water normal temperature flash extraction , the weight of water is 6 times of the weight of the biotransformation "mycelium"; in the second water normal temperature flash extraction, the weight o...

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Abstract

The invention discloses a bioconversion mycelium medium, bioconversion mycelium and a bioconversion mycelium extract, the bioconversion mycelium medium is produced by adding traditional Chinese medicine earthworm into an agricultural and sideline product culture medium, the bioconversion mycelium is a product obtained by inoculating hericium erinaceus into the bioconversion mycelium medium for mycelium conversion culture, the bioconversion mycelium extract is a product obtained by water extraction treatment, and the bioconversion mycelium extract has anticoagulation effect which is obviously better than the anticoagulation effect of hericium erinaceus mycelium or earthworm, and can be used for the preparation of anticoagulant drugs.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and specifically relates to a biotransformation "mycelium" (the quotation marks in the text indicate the specific reference to the mycelium) and the application of its extract in the preparation of anticoagulant drugs. Background technique [0002] Blood coagulation refers to the process in which blood changes from a flowing liquid state to an immobile gel state, and is an important part of the physiological hemostasis process. The essence of blood coagulation is the process of converting soluble fibrinogen in plasma into insoluble fibrin. When the formed fibrin interweaves into a network, blood cells and other blood components can be trapped, thereby forming a blood clot. Blood coagulation is a series of complex enzymatic reaction process, which requires the participation of various coagulation factors. The activation of prothrombin is carried out under the action of prothrombin enz...

Claims

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Application Information

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IPC IPC(8): C12N1/14A61K36/06A61P7/02C12R1/645
CPCA61K36/07C12N1/14
Inventor 何述金常耀台周代俊张如
Owner HUNAN XINHUI PHARMA
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