Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicine composition containing metronidazole

A composition and technology of metronidazole, applied in the field of medicine, can solve problems such as easy damage to the acid-base environment of the vagina

Active Publication Date: 2015-04-29
BEIJING UNIS PHARMA
View PDF2 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(4) Excessive emphasis on hygiene: In order to maintain hygiene, some women often use medicinal lotion to lavage the vagina, which can easily destroy the acid-base environment of the vagina and cause bacterial vaginosis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicine composition containing metronidazole
  • Medicine composition containing metronidazole

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Metronidazole 375g, carbomer 934 450g, propylene glycol 1100g, solubilizer and pH regulator are sodium citrate and L-arginine 180g, sodium citrate 144g, L-arginine 36g.

[0070] Preparation method: take L-arginine, 50% by weight of sodium citrate, add 28 kg of water to dissolve completely, add carbomer 934, and stir evenly; add the remaining 50% by weight of sodium citrate, add 9.7 kg of water, and heat to 50°C; add metronidazole, stir evenly, add propylene glycol, stir evenly, fill, and obtain 10,000 gels.

Embodiment 2

[0072] Metronidazole 375g, carbomer 934 450g, propylene glycol 1100g, solubilizer and pH regulator are sodium citrate and L-arginine 180g, sodium citrate 140g, L-arginine 40g.

[0073] Preparation method: take L-arginine, 50% by weight of sodium citrate, add 28 kg of water to dissolve completely, add carbomer 934, and stir evenly; add the remaining 50% by weight of sodium citrate, add 9.7 kg of water, and heat to 50°C; add metronidazole, stir evenly, add propylene glycol, stir evenly, fill, and obtain 10,000 gels.

Embodiment 3

[0075] Metronidazole 375g, carbomer 934 450g, propylene glycol 1100g, solubilizer and pH regulator are sodium citrate and L-arginine 180g, sodium citrate 128.6g, L-arginine 51.4g.

[0076] Preparation method: take L-arginine, 50% by weight of sodium citrate, add 28 kg of water to dissolve completely, add carbomer 934, and stir evenly; add the remaining 50% by weight of sodium citrate, add 9.7 kg of water, and heat to 50°C; add metronidazole, stir evenly, add propylene glycol, stir evenly, fill, and obtain 10,000 gels.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicines, and discloses a medicine composition containing metronidazole. The medicine composition comprises metronidazole, carbomer 934, propylene glycol, a solubilizer, a pH regulator and a complexing agent. The invention also discloses another medicine composition containing metronidazole. Another medicine composition disclosed by the invention is prepared from the following components in parts by weight: 35-45 parts of metronidazole, 40-50 parts of carbomer 934, 100-120 parts of propylene glycol, a solubilizer and 15-20 parts of a pH regulator, namely sodium citrate and L-arginine. Tests indicate that vaginal gel prepared from the medicine composition has better safety and stability.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing metronidazole. Background technique [0002] Bacterial vaginosis (BV) is a mixed infection caused by Gardnerella vaginalis and some aerobic bacteria, which leads to an imbalance in the microecological balance in the vagina, resulting in increased vaginal discharge, fishy vaginal discharge, and itching and burning of the vulva. syndrome. It can be divided into haemophilus vaginitis, corynebacterium vaginitis, aerobic bacteria vaginitis, Gardnerella vaginitis and so on. The disease can also be transmitted through sexual contact, and the incidence rate is higher among people with disordered sexual relations. [0003] The causes of bacterial vaginosis mainly include the following aspects: (1) Indirect contact infection: contact with toilets, bathtubs, bath chairs, towels in public toilets contaminated by bacteria, and use of uncl...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/4164A61K47/32A61K47/18A61K47/12A61P31/04A61P15/02
Inventor 张轶蒋朝文曹捷
Owner BEIJING UNIS PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com