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Drug composition for treating cerebral infarction or/and coronary heart disease stenocardia and preparation method and application thereof

A technology for coronary heart disease angina pectoris and a composition is applied in the field of pharmaceutical compositions for the treatment of cerebral infarction or/and coronary heart disease angina pectoris, and can solve problems such as difficulty in obtaining curative effects and the like

Active Publication Date: 2015-04-22
SICHUAN CHUANDA WEST CHINA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Existing studies have shown that cardiovascular and cerebrovascular diseases are a complex, dynamic and continuous process, a multi-link, multi-level, multi-factor, multi-path, multi-site process, such as only treating a certain link , it is difficult to achieve the ideal curative effect

Method used

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  • Drug composition for treating cerebral infarction or/and coronary heart disease stenocardia and preparation method and application thereof
  • Drug composition for treating cerebral infarction or/and coronary heart disease stenocardia and preparation method and application thereof
  • Drug composition for treating cerebral infarction or/and coronary heart disease stenocardia and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: pharmaceutical composition tablet of the present invention

[0023] Weigh 16g of paeoniflorin, 6g of hydroxysafflower pigment A, and 0.2g of rutin, mix well, add 140g of starch, 33g of dextrin and 5.5g of powdered sugar, add 5% starch slurry to make soft material, pass through a 16-mesh sieve to make wet granules , dry the wet granules at 60-70°C, sieve the dry granules with a 20-mesh sieve, add 2% magnesium stearate, mix them evenly, and compress them into tablets.

Embodiment 2

[0024] Embodiment 2: pharmaceutical composition capsule of the present invention

[0025] Weigh 14g of paeoniflorin, 8g of hydroxysafflower pigment A, and 0.4g of rutin, mix well, add 110g of starch, 63g of dextrin and 5g of powdered sugar, add 85% ethanol to make soft material, pass through a 20-mesh sieve to make wet granules, The wet granules were dried at 60-70°C, and the dry granules were sieved with a 20-mesh sieve to make 200g, and divided into 0.2g / capsules to make 1,000 granules in total.

Embodiment 3

[0026] Embodiment 3: pharmaceutical composition granule of the present invention

[0027] Weigh 60g of paeoniflorin, 30g of hydroxysafflower pigment A, and 3g of rutin, mix evenly, fluidize with lactose in an intermittent fluidized bed, dry, add 85% ethanol to make soft material, pass through a 20-mesh sieve to make wet granules , dry the wet granules at 60-70°C, sieve the granules with a 20-mesh sieve, make 1000g, and pack them into 3g / bags.

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Abstract

The invention relates to a drug composition for treating cerebral infarction or / and coronary heart disease stenocardia. The drug composition is prepared from the following active ingredients of, by weight, 1-10 parts of paeoniflorin, 1-5 parts of hydroxyl safflower pigment A and 0.1-0.5 part of rutin. The invention further provides a preparation method and application of the drug composition. The problems that only one single drug is used, action targets are fewer, the drug achieves the treatment purpose through one target, and the consumed drug dosage is large are solved. Based on the principle of achieving the same goal by different ways, the three drugs acting on different mechanisms are combined, the drugs are synergistic and interact, the effect of the drugs is superior to the summing effect of the independent drug solid, and therefore the purpose of treating or preventing cardiovascular and cerebrovascular diseases is achieved. Paeoniflorin, hydroxyl safflower pigment A and rutin are different in action mechanisms in the aspect of treating the cardiovascular and cerebrovascular diseases and have the synergistic effect when matched in the application process, and the treatment effect is superior to that of single application only when the three drugs are combined together to be applied.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cerebral infarction or / and coronary heart disease angina pectoris. Background technique [0002] my country is a country with a high incidence of cerebrovascular diseases. With the continuous improvement of people's material living standards and the increase of the aging population, the incidence is rapidly increasing. Cerebral infarction, cerebral arteriosclerosis, coronary heart disease, angina pectoris and other cardiovascular and cerebrovascular diseases seriously threaten human life and health. According to epidemiological investigations, the incidence and death of cardiovascular and cerebrovascular diseases have The mortality rate of cardiovascular and cerebrovascular diseases in my country has jumped to the top of various diseases. [0003] Cerebral infarction refers to multiple ischemic softening infarcts in the brain, also known as multiple encephalomalacia, accompanied by para...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/10A61K31/351
CPCA61K9/1652A61K9/19A61K9/2036A61K9/2059A61K31/351A61K31/7048A61K47/26A61K2300/00
Inventor 聂阳金莎丽毛洁何盛江
Owner SICHUAN CHUANDA WEST CHINA PHARMA
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