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Leukemia and myeloma treating plant extract and natural chemical monomer

A plant extract, leukemia technology, applied in the field of medicine, can solve the problems of incurability, large side effects, high price, etc.

Inactive Publication Date: 2004-12-29
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are many types of drugs for the treatment of leukemia and multiple myeloma, with different curative effects. Most of them are chemically synthesized drugs. These drugs have large side effects and cannot be cured
In recent years, foreign countries have successively developed some new chemotherapeutic drugs with strong pertinence, good curative effect and relatively small side effects, but they are expensive.

Method used

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  • Leukemia and myeloma treating plant extract and natural chemical monomer
  • Leukemia and myeloma treating plant extract and natural chemical monomer
  • Leukemia and myeloma treating plant extract and natural chemical monomer

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Embodiment Construction

[0100] 1. Adding Narcissus extract to a variety of leukemia cell lines, multiple myeloma cell lines and other malignant tumor cell lines to culture together has a very obvious inhibitory effect on the growth of these cells. For example, the proliferation inhibition rate of multiple myeloma cell line ARH-77 can reach more than 90%. Using flow cytometry technology, fluorescent photography technology, electron microscopy technology, gene amplification technology in vitro, gel electrophoresis technology, etc., it was further confirmed that the inhibitory effect of Narcissus extract on these cells was through inhibiting protein synthesis, inhibiting cell proliferation, and promoting cell apoptosis. death to achieve.

[0101] 2. Lycorine was used to treat leukemia and multiple myeloma cell lines, and it was found that the cell volume became smaller, the cells were rare, and the cell proliferation rate was significantly inhibited. Using flow cytometry technology, fluorescent photogr...

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Abstract

The present invention is plant extractive and natural compound for treating leukaemia and multiple myeloma. The natural compound includes amarylline, homoamarylline, narcissus krasin, ungernine, preungernine, amarylline and pseudoamarylline is used mainly in treating multiple myeloma. The said plant extractive, compound and their derivative are matched with other medicine to form compound medicine for treating leukaemia and multiple myeloma with less toxic side effect and higher curative effect. The plant extractive and the natural compound can inhibit cell protein synthesis, inhibit cell proliferation and promoting cell death to reach the aim of treating leukaemia and multiple myeloma.

Description

technical field [0001] The present invention relates to medicines, and further refers to plant extracts and natural compound monomers thereof. Background technique [0002] Leukemia and multiple myeloma are common hematological malignancies with a high incidence rate. In my country, there are about 3 to 4 leukemia patients per 100,000 population. The incidence rate in western developed countries is generally higher than that in my country. For example, the incidence rate in the United States is 6.8 to 9.3 per 100,000 population; in my country, multiple myeloma is about 1 per 100,000 population, and in western developed countries it is 4 per 100,000 population. There are many types of drugs for treating leukemia and multiple myeloma, with different curative effects. Most of them are chemically synthesized drugs. These drugs have large side effects and cannot be cured. In recent years, foreign countries have successively developed some new chemotherapeutic drugs with strong pe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/407A61K31/475A61P35/00
Inventor 胡维新刘静何莉芳
Owner CENT SOUTH UNIV
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