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Uses of compositions containing roasted extract and xanthohumol

A technology of composition and extract, applied in the directions of medical preparations, drug combinations, plant raw materials, etc. containing active ingredients, can solve problems such as verification, and achieve the effect of detoxification prevention

Inactive Publication Date: 2015-04-08
TA XAN AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

4–6 mg / kg xanthohumol administered daily in drinking water as described in Monteiro et al. (2008), Xanthohumol inhibits inflammatory factor production and angiogenesis in breast cancer xenografts, J. Cell Biochem., e-pub Afterwards, tumor growth was inhibited by 35%, however this result could not be statistically verified at the 95% level

Method used

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Examples

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Embodiment 1

[0097] Example 1: The preparation of the pharmaceutical composition for medical purposes described in the application

[0098]Malt comprising 1.9 kg of roasted barley malt (Carafa(TM), type 2, Fa. Weyermann, Bamberg) and 0.1 kg of Pilsen type malt was mashing and the mash was separated according to the Brewers Congress method After (mash), 25 g / l of XN-enriched hop extract (XanthoExtrakt, Simon H. Steiner Hopfen GmbH, XN 2.0%) was added during the boiling of the roasted malt. After separation of the hot residue and separation with diatomaceous earth, the roasted malt containing XN was concentrated in vacuo (200 mbar, about 55° C.) to obtain an extract with a content of about 50% w / w. The syrupy extract ("density 1.25" kg / l) had an XN content of about 1320 mg / kg. The roasted malt extract containing XN can be directly mixed with any conventional pharmaceutical carriers and additives as required.

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PUM

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Abstract

The present invention primarily relates to specific uses of a composition containing a roasted extract and xanthohumol for health-promoting purposes. In particular, the invention relates to a composition, preferably pharmaceutical composition, comprising xanthohumol (XN), preferably in a therapeutically effective amount, for (i) use in the treatment and / or prevention of cancer, and / or (ii) use in the treatment and / or prevention of osteoporosis, and / or (iii) use in the treatment and / or prevention of metabolic syndrome, and / or (iv) use in the treatment and / or prevention of diabetes, and / or (v) use in the treatment and / or prevention of cardiovascular disease(s), and / or (vi) use as anti-oxidant, and / or (vii) use as detoxifying agent, and / or (viii) inhibiting metabolic activation of procarcinogenes, and / or (ix) use as anti-mutagenic and / or anti-genotoxic agent, and / or (x) use as anti-estrogenic and / or estrogenic agent, and / or (xi) inducing apoptosis, and / or (xii) use as anti-angiogenetic agent, and / or (xiii) use as anti-inflammatory agent, and / or (xiv) inhibiting NF-kappaBeta, and / or (xv) use in the treatment and / or prevention of infection(s), in particular, use as antimicrobial agent, wherein the composition comprises or consists of (a) a roasted extract and (b) XN, preferably a hop extract comprising XN, and / or wherein the composition is obtainable or obtained by mixing (a) a roasted extract and (b) XN or, preferably, a hop extract comprising XN.

Description

technical field [0001] The present invention mainly relates to the specific use of compositions comprising roasted extracts and xanthohumol for health promotion purposes. Background technique [0002] It is well known that xanthohumol has very diverse positive effects on human and animal health. For example, in addition to antimicrobial effects, preventive activity against a wide range of diseases caused by various mechanisms was also observed. [0003] For example, cancer preventive activity, protection against osteoporosis, metabolic syndrome, diabetes and cardiovascular disease have been reported. [0004] It should be mentioned that these sub-divisions cannot be strict. For example, antioxidative effects are positive in the prevention of tumors as in, for example, metabolic syndrome or other diseases, and studies related to xanthohumol have not been performed so far. [0005] Numerous studies have described cancer prevention mechanisms and have been studied in vitro, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61K36/00
CPCA61K31/12A61K36/185A61P11/00A61P11/06A61P13/12A61P15/00A61P19/02A61P19/10A61P29/00A61P3/00A61P3/14A61P31/00A61P31/04A61P31/12A61P33/00A61P35/00A61P39/02A61P39/06A61P43/00A61P5/30A61P5/32A61P9/00A61P9/10A61P3/10A61K2300/00A61K36/74A61K36/8998A61K36/899
Inventor W.巴克A.朱尔彻S.旺德利克
Owner TA XAN AG
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