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Licorice liquid fermented product, cosmetics containing fermented product, preparation method and use thereof

A technology of liquid fermentation and cosmetics, applied in cosmetic preparations, cosmetics, medical preparations containing active ingredients, etc., can solve the problems of licorice and lactic acid bacteria without anti-inflammatory, anti-allergic, anti-itching, etc., to reduce body licking The effect of times

Active Publication Date: 2019-03-01
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, neither licorice nor lactic acid bacteria have been reported to have anti-inflammatory, anti-allergic, and anti-itch effects.

Method used

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  • Licorice liquid fermented product, cosmetics containing fermented product, preparation method and use thereof
  • Licorice liquid fermented product, cosmetics containing fermented product, preparation method and use thereof
  • Licorice liquid fermented product, cosmetics containing fermented product, preparation method and use thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 liquid medium influences the growth adaptability test of lactic acid bacteria

[0030] (1) by 1.0×10 5 cfu / ml inoculum amount Lactic acid bacteria were respectively inoculated in liquid culture medium containing 5.0%, 10.0%, 15.0%, and 20.0% licorice (both based on crude drug weight, the same below), and cultivated at 37°C and 50rpm for 3 to 5 On the first day, the number of lactic acid bacteria colonies in the fermentation broth was detected by plate coating method. The results are shown in Table 1.

[0031] The results in Table 1 show that when the content of licorice is 10.0%, the growth of lactic acid bacteria is good and basically consistent; when the concentration of licorice in the medium is greater than 10%, the growth of lactic acid bacteria is inhibited. Therefore, in the liquid fermentation base, the optimum content of licorice is 10%.

[0032] Table 1 Effects of licorice content and fermentation time on the culture of lactic acid bacteria

...

Embodiment 2

[0039] Embodiment 2 Efficacy test and irritation test of licorice liquid fermented product

[0040] Add the above-mentioned licorice root in the weight of crude drug into the culture medium in a percentage of 10.0%, and press 1.0×10 6 After being inoculated with lactic acid bacteria in the amount of cfu / ml, cultured for 5 days at 37° C. and 50 rpm to obtain said licorice liquid fermented product, the following efficacy test and irritation test were carried out.

[0041] 1. Xylene-induced mouse ear swelling test

[0042] 70 Kunming mice, half female, 18-22g, were randomly divided into normal control group, model control group, high, medium and low dose groups (10ml / kg, 5ml / kg, 2.5ml / kg ), licorice medicinal material group (10% concentration, 5ml / kg), lactic acid bacteria liquid fermentation product group (5ml / kg), 10 rats in each group. Except for the normal control group, the mice in other groups were smeared with xylene on the front and back sides of the right ear to induce...

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Abstract

The invention belongs to the field of biological fermentation and particularly relates to a licorice liquid fermentation product, a cosmetic containing the fermentation product and a preparation method and application thereof. The anti-inflammatory and antiallergic product having itching relieving effect is provided with the guidance of a 'biotransformation theory' and by adopting a licorice and lactobacillus liquid fermentation system. Licorice is added into a culture medium, and then the licorice and lactobacillus are fermented to obtain a liquid fermentation mixture, wherein the culture medium contains, by crude drug weight, the licorice 5-20%, and the inoculum size of the lactobacillus is 1.0*104-1.0*108cfu / ml.

Description

technical field [0001] The invention belongs to the field of biological fermentation, and in particular relates to liquorice liquid fermented products, cosmetics containing fermented products, their preparation methods and applications. Background technique [0002] Licorice is a tonic Chinese herbal medicine in traditional Chinese medicine. The medicinal licorice is the root and rhizome of the genus Glycyrrhizae of the leguminous family. The Chinese Pharmacopoeia records that licorice has the effects of invigorating the spleen and replenishing qi, clearing heat and detoxifying, eliminating phlegm and relieving cough, relieving spasm and relieving pain, and harmonizing various medicines. The main chemical components of licorice are flavonoids, subacids, and sweeteners. Western medicine has found that licorice has anti-inflammatory and anti-allergic functions, so it is mainly used as a palliative in Western medicine. In cosmetics, the flavonoids contained in licorice have th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/99A61K8/9789A61Q19/00A61K36/484A61P17/04A61P37/08A61P29/00
Inventor 罗霞江南魏巍余梦瑶许晓燕
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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