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Tablet comprising melissa officinalis folium extract for preventing or treating angiogenesis or mmp activity-mediated disease

An angiogenesis and activity-mediated technology, applied in metabolic diseases, pill delivery, drug combination, etc., can solve the problem of not fully considering the active ingredients, etc., and achieve the effect of excellent release rate

Inactive Publication Date: 2015-03-25
HANMI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] However, the above-mentioned prior arts do not sufficiently consider active ingredients exhibiting medicinal effects derived from lemon balm leaf extracts and suitable formulations for administration to human bodies

Method used

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  • Tablet comprising melissa officinalis folium extract for preventing or treating angiogenesis or mmp activity-mediated disease
  • Tablet comprising melissa officinalis folium extract for preventing or treating angiogenesis or mmp activity-mediated disease
  • Tablet comprising melissa officinalis folium extract for preventing or treating angiogenesis or mmp activity-mediated disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1: Analysis of components and ratios in a dried ethyl acetate extract of Lemon balm leaves

[0046] In order to extract active ingredients from raw material Lemon balm leaves, extracts were prepared as follows and used for component analysis.

[0047] Specifically, 200 kg of dried lemon balm leaves were reflux extracted with 75% ethanol totaling 20 times the weight of the dried lemon balm leaves for 4 hours, filtered through a cartridge filter, and concentrated for the first time under reduced pressure. . The thus obtained concentrate (amount: 50 kg) was fractionally distilled with a mixture of ethyl acetate and water (1:1 (v / v)) (amount: 50 kg), which was repeated twice. Next, the ethyl acetate layer was collected, concentrated for the second time under reduced pressure, dried and pulverized to obtain an ethyl acetate extract of Lemon balm leaves (amount: 8.2 kg). The above process was performed in triplicate to determine the reproducibility for the extractio...

Embodiment 2

[0056] Example 2: Preparation of Tablets Containing Lemon Balm Lemon Balm Leaf Extract - (1)

[0057]According to the amount (unit: mg) recorded in the following Table 3, by adding microcrystalline cellulose (MCC, Avicel PH101, FMC biopolymer) and light anhydrous silicic acid (Aerosil 200, Degussa) as excipients, Sodium starch glycolate (SSG, YUNG ZIP Chem) as a disintegrant and magnesium stearate (S-Mg, NOF Corporation) as a lubricant were mixed with the dried ethyl acetate of Lemon balm leaves prepared in Example 1. The extracts are mixed and then subjected to direct compression to prepare tablets.

Embodiment 3

[0058] Example 3: Preparation of Tablets Containing Lemon Balm Lemon Balm Leaf Extract - (2)

[0059] According to the amount (unit: mg) recorded in the following Table 3, by mixing the dried ethyl acetate of the Lemon balm leaf extract prepared in Example 1 with MCC and SSG, the mixture was mixed with the binder solution (dissolved in Hydroxypropylcellulose (HPC-L, Shin-Etsu)) in water was uniformly mixed, and the resulting mixture was granulated to prepare granules. The prepared granules were dried at 50° C. for 2 hours, passed through a 20-mesh sieve, mixed with light anhydrous silicic acid as an excipient and S-Mg as a lubricant, and then compressed to prepare a tablet.

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PUM

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Abstract

The present invention relates to a tablet for preventing or treating angiogenesis or matrix metalloproteinase (MMP) activity-mediated disease, the tablet comprising Melissa (Melissa officinalis) folium extract having rosmarinic acid, caffeic acid, and rutin as major active ingredients, and a pharmaceutically acceptable disintegrator. The tablet in which the dissolution rates of the rosmarinic acid or the caffeic acid are 80% or more within 30 minutes has an excellent release rate and is stable under accelerated conditions, and thus the tablet may be used effectively for the prevention or the treatment of angiogenesis or MMP activity-mediated disease, in particular, obesity.

Description

technical field [0001] The present invention relates to a tablet for preventing or treating diseases mediated by angiogenesis (angiogenesis) or matrix metalloproteinase (matrix metalloproteinase, MMP) activity, the tablet comprising Lemon balm (Melissa officinalis) leaf extract (wherein, marinic acid, caffeic acid and rutin (rutin, rutin) are the main active ingredients) and pharmaceutically acceptable disintegrants. Background technique [0002] Lemon balm (Melissa, Melissa officinalis), a perennial herb of the Lamiaceae family, is also called lemon balm. [0003] Lemon balm leaf extract contains flavonoids, terpene acids, volatile oils, glycosides and caffeic acid derivatives of alcohols and phenolic compounds. In particular, flavonoids contained in large amounts in lemon balm leaves include luteolin, cosmosin, rhamnocitrin, and isoquercitrin; and include ursolic acid as a terpene acid. Among these non-volatile components, rosmarinic acid is included, and caffeic acid de...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K36/53A61P3/04A61P3/00
CPCA61K9/2054A61K9/2059A61K36/53A61K2236/39A61P3/00A61P3/04A61K9/20
Inventor 尹银镇金京洙金用镒朴宰贤禹钟守
Owner HANMI PHARMA
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