Process for extracting high-content liquid gingerol

An extraction process, gingerol technology, applied in the field of plant extracts and its preparation, can solve the problems of heavy metal residues in product changes, low separation efficiency, high production costs, etc., to achieve better product quality, good repeatability, and quality Guaranteed effect

Inactive Publication Date: 2015-03-25
QINGDAO ZHONGREN ZHIYE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] So far, the methods for preparing high-content gingerol mainly include solvent extraction and separation-multiple solvent extraction, supercritical extraction combined with column chromatography, etc. These methods In the process of separation and purification, high temperature is required, or a large amount of organic solvent is used, or it is in contact with separation materials containing a lot of heavy metals, which may easily lead to product changes or heavy metal residues, and the process is complicated, the separation efficiency is low, and the production cost High disadvantage

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  • Process for extracting high-content liquid gingerol

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Effect test

Embodiment 1

[0035] The preparation method of the high-content liquid gingerol described in the present embodiment may further comprise the steps:

[0036] (1) Use 0.5 kg of ginger resin, its gingerol content is 38.2%, the conditions for supercritical carbon dioxide extraction are: extraction pressure / temperature 30MPA / 40°C, primary separation pressure / temperature 12MPA / 45°C, secondary separation pressure / Temperature 5MPA / 35°C. The ginger resin is obtained in the primary separator, and mainly volatile components in the secondary separator. Adding 2.25 kilograms of weight percent concentration in the ginger resin is 70% ethanol aqueous solution, stirs, removes a small amount of insolubles by filtration, obtains a clear ginger resin alcohol solution;

[0037] (2) if figure 1 As shown, the above-mentioned ginger resin alcohol solution was transferred to a glass liquid-liquid extractor (diameter 90 mm × height 1100 mm), and then the petroleum ether (boiling range 60 ~ 90 ° C) was passed ...

Embodiment 2

[0042] The preparation method of the high-content liquid gingerol described in the present embodiment may further comprise the steps:

[0043] (1) Use 1.0 kg of ginger resin, whose gingerol content is 39.4%. The conditions for supercritical carbon dioxide extraction are: extraction pressure / temperature 30MPA / 45°C, primary separation pressure / temperature 13MPA / 45°C, secondary separation pressure / Temperature 5MPA / 35°C. The ginger resin is obtained in the primary separator, and mainly volatile components in the secondary separator. Adding 4.0 kilograms of weight percent concentration therein is 75% ethanol aqueous solution, stirs, removes a small amount of insoluble matter by filtration, obtains clear ginger resin alcohol solution;

[0044] (2) The alcoholic solution of the above-mentioned ginger resin is transferred to a glass liquid-liquid extractor (diameter 90 mm × height 1100 mm), and then the petroleum ether (boiling range 60~90 ℃) is passed through the bottom of th...

Embodiment 3

[0048] The preparation method of the high-content liquid gingerol described in the present embodiment may further comprise the steps:

[0049] (1) Use 2.0 kg of ginger resin, whose gingerol content is 37.1%. The conditions for supercritical carbon dioxide extraction are: extraction pressure / temperature 32MPA / 45°C, primary separation pressure / temperature 14MPA / 50°C, secondary separation pressure / Temperature 5MPA / 35°C. The ginger resin is obtained in the primary separator, and mainly volatile components in the secondary separator. Adding 7.5 kilograms of weight percent concentration wherein is the aqueous ethanol solution of 80%, stirs, removes a small amount of insoluble matter by filtration, obtains clear ginger resin alcohol solution;

[0050] (2) The alcoholic solution of the above-mentioned ginger resin is transferred to a glass liquid-liquid extractor (110 mm in diameter × 1300 mm in height), and then petroleum ether (boiling range 60~90 ° C) is passed through the extra...

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Abstract

The invention discloses a process for extracting high-content liquid gingerol. The process comprises the following steps: by virtue of the characteristic that the solubility degrees of different components in natural and high-quality ginger oleoresin which is extracted by using supercritical carbon dioxide are greatly different in ethanol and petroleum ether of a certain concentration, continuously extracting fat soluble impurity components in ethanol phase by using petroleum ether, further extracting by using diethyl ether, separating and purifying, thereby obtaining high-content liquid gingerol. The high-content liquid gingerol is a light brown red liquid with relatively poor flowability, is quietly elegant and pure in fragrance and long-lasting in base fragrance, the content of gingerol is greater than 90%, and the residual amounts of heavy metals such as arsenic, cadmium, lead and mercury are all less than 0.1ppm.

Description

technical field [0001] The invention relates to a plant extract and a preparation method thereof, in particular to a high-content gingerol and a preparation method thereof. Background technique [0002] Ginger is a medicinal and edible plant that is closely related to people's life and health. Regardless of ancient or modern times, or at home and abroad, ginger and its products have never left people's lives. Studies have shown that the main active ingredients of raw (dry) ginger are volatile oil and gingerol. Gingerol is a general term for a variety of substances with similar structures in raw (dried) ginger, all of which contain 3-methoxy-4-hydroxyphenyl functional groups, mainly including gingerols (Gingerols) , Shogals, Paradols, Zingerones, Gingerdiones, Gingerdiols, and gingerol is its main component. [0003] Modern pharmacological research has found that gingerol is the main active ingredient in the pharmacological effects of ginger and its preventive and health ca...

Claims

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Application Information

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IPC IPC(8): C07C49/255C07C45/78
CPCC07C45/78C07C49/255Y02P20/54
Inventor 侯维
Owner QINGDAO ZHONGREN ZHIYE BIOTECH
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