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A kind of composite medical hydrogel dressing material and preparation method thereof

A hydrogel and medical technology, applied in the field of medical dressing materials and their preparation, can solve the problems of reducing the mechanical strength and low breaking strength of hydrogels, achieve good biocompatibility, improve the breaking strength, and increase the water absorption swelling rate. Effect

Inactive Publication Date: 2017-02-08
北京中科贴针灸健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its breaking strength is low, which reduces the mechanical strength of the hydrogel, so there is still room for improvement in its mechanical strength

Method used

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  • A kind of composite medical hydrogel dressing material and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Take deionized water and pour it into the reactor, raise the temperature of the reactor to 65°C, and slowly add alginic acid with a molecular weight of 20-100kDa and gelatin with a molecular weight of 25-60kDa into the reactor after the temperature stabilizes, add Mechanically stir the alginic acid and gelatin at the same time, and the mechanical stirring speed is 150r / min; (2) After adding the alginic acid and gelatin, continue to stir for 15 minutes, and then add polyvinyl alcohol and hydroxypropyl alcohol with a molecular weight of 100-150kDa to the reactor Methyl cellulose and propylene glycol were added while being mechanically stirred at a stirring speed of 60r / min; (3) After the above materials were mixed, the hydrogel was cooled to room temperature, and the alginic acid in the prepared hydrogel dressing material 25wt% gelatin, 3wt% polyvinyl alcohol, 20wt% hydroxypropyl methylcellulose, 5wt% propylene glycol, and water as the balance.

Embodiment 2

[0035] (1) Take deionized water and pour it into the reactor, raise the temperature of the reactor to 85°C, and slowly add alginic acid with a molecular weight of 20-100kDa and gelatin with a molecular weight of 25-60kDa into the reactor after the temperature stabilizes, add Mechanically stir the alginic acid and gelatin at the same time, and the mechanical stirring speed is 100r / min; (2) After adding the alginic acid and gelatin, continue to stir for 10min, and then add polyvinyl alcohol and hydroxypropyl alcohol with a molecular weight of 100-150kDa to the reactor Methyl cellulose and propylene glycol were added while being mechanically stirred at a stirring speed of 30r / min; (3) After the above materials were mixed, the hydrogel was cooled to room temperature, and the alginic acid in the prepared hydrogel dressing material 10wt% gelatin, 10wt% polyvinyl alcohol, 5wt% hydroxypropyl methylcellulose, 2wt% propylene glycol, and water as the balance.

Embodiment 3

[0037] (1) Take deionized water and pour it into the reactor, raise the temperature of the reactor to 65°C, and slowly add alginic acid with a molecular weight of 20-100kDa and gelatin with a molecular weight of 25-60kDa into the reactor after the temperature stabilizes, add Mechanically stir the alginic acid and gelatin at the same time, and the mechanical stirring speed is 150r / min; (2) After adding the alginic acid and gelatin, continue to stir for 15 minutes, and then add polyvinyl alcohol and hydroxypropyl alcohol with a molecular weight of 100-150kDa to the reactor Methyl cellulose and propylene glycol were added while being mechanically stirred at a stirring speed of 60r / min; (3) After the above materials were mixed, the hydrogel was cooled to room temperature, and the alginic acid in the prepared hydrogel dressing material 20wt% gelatin, 5wt% polyvinyl alcohol, 15wt% hydroxypropyl methylcellulose, 3wt% propylene glycol, and water as the balance.

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Abstract

The invention belongs to the field of new medical materials, and discloses a composite medical hydrogel dressing material and a preparation method thereof. The composite medical hydrogel dressing material comprises the following components in percentage by weight: 10-25wt% of alginic acid, 5-15wt% of gelatin, 3-10wt% of polyvinyl alcohol, 5-20wt% of hydroxypropyl methyl cellulose, 2-5wt% of propylene glycol and the balance of water. The preparation method comprises the following steps: (1) pouring deionized water into a reactor, rising the temperature of the reactor to 65-85 DEG C, slowly adding alginic acid and gelatin into the reactor after the temperature is stabilized, and mechanically stirring; (2) after alginic acid and gelatin are completely added, adding polyvinyl alcohol, hydroxypropyl methyl cellulose and propylene glycol, and mechanically stirring; and (3) cooling to room temperature. By adopting the preparation method disclosed by the invention, the hydrogel dressing material with excellent performance and good biocompatibility can be prepared.

Description

technical field [0001] The invention belongs to the field of new medical materials, and relates to a medical dressing material and a preparation method thereof, in particular to a [0002] Composite medical hydrogel dressing material and preparation method thereof. Background technique [0003] Hydrogel refers to a gel that uses water as a dispersion medium. A water-soluble polymer with a cross-linked structure introduces a part of hydrophobic groups to form a water-swellable cross-linked polymer. It is a polymer network system, which is soft in nature, can maintain a certain shape, and can absorb a large amount of water. All water-soluble or hydrophilic polymers can form hydrogels through certain chemical cross-linking or physical cross-linking. According to different sources, hydrogels can be divided into natural hydrogels and synthetic hydrogels; according to their properties, they can be divided into electrically neutral hydrogels and ionic hydrogels; The situation i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/42A61L15/28A61L15/32A61L15/24A61L15/20
Inventor 吴振彪
Owner 北京中科贴针灸健康科技有限公司
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