Tetracaine hydrochloride oral effervescent tablet and preparation method thereof

A technology of tetracaine hydrochloride and effervescent tablets, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, anesthetics, etc., can solve the problems of inability to expose the glottis and threaten the life safety of patients, so as to reduce pain and improve comfort. degree of effect

Inactive Publication Date: 2015-03-25
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for patients with difficult airway, after induction of general anesthesia, the glottis cannot be exposed, or the endotracheal tube cannot be inserted into the glottis after blind exploration, which will seriously threaten the patient's life safety

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Tetracaine hydrochloride oral effervescent tablets, composed of the following components: tetracaine hydrochloride 10-30mg, tartaric acid 100mg, sodium bicarbonate 150mg, aspartame 2.5mg, sodium chloride 10mg, mannitol 100mg, 10% PVP Absolute ethanol solution 72.5mg, PEG6000 10mg.

[0019] The method for preparing tetracaine hydrochloride oral effervescent tablet may further comprise the steps:

[0020] (1) Turn on the indoor purifier for 1-2 hours, control the room temperature to 20-25°C, and control the relative humidity to below 35%;

[0021] (2) Weigh 100mg of tartaric acid, 150mg of sodium bicarbonate, 2.5mg of aspartame, 10mg of sodium chloride, and 100mg of mannitol, respectively pass through a 60-100 mesh sieve, add them into a three-dimensional mixer, and stir for 15-60 minutes;

[0022] (3) Precisely weigh 10-30mg of tetracaine hydrochloride, add it to the above mixed material by equal increment method, stir for 10-30 minutes, make the material fully mixed, a...

Embodiment 2

[0025] Tetracaine hydrochloride oral effervescent tablets, composed of the following components: tetracaine hydrochloride 10-30mg, tartaric acid 125mg, sodium bicarbonate 175mg, aspartame 2.5mg, sodium chloride 10mg, mannitol 125mg, 10% PVP Absolute ethanol solution 131.25mg,

[0026] PEG6000 10mg.

[0027] The method for preparing tetracaine hydrochloride oral effervescent tablet may further comprise the steps:

[0028] (1) Turn on the indoor purifier for 1-2 hours, control the room temperature to 20-25°C, and control the relative humidity to below 35%;

[0029] (2) Weigh 125mg of tartaric acid, 175mg of sodium bicarbonate, 2.5mg of aspartame, 10mg of sodium chloride, and 125mg of mannitol, respectively pass through a 60-100 mesh sieve, add them into a three-dimensional mixer, and stir for 15-60 minutes;

[0030] (3) Precisely weigh 10-30mg of tetracaine hydrochloride, add it to the above mixed material by equal increment method, stir for 10-30 minutes, make the material fu...

Embodiment 3

[0033] Tetracaine hydrochloride oral effervescent tablets are composed of the following components: tetracaine hydrochloride 10-30mg, tartaric acid 200mg, sodium bicarbonate 300mg, aspartame 5mg, sodium chloride 20mg, mannitol 200mg, 10% PVP without Water ethanol solution 145mg, PEG6000 20mg.

[0034] The method for preparing tetracaine hydrochloride oral effervescent tablet may further comprise the steps:

[0035] (1) Turn on the indoor purifier for 1-2 hours, control the room temperature to 20-25°C, and control the relative humidity to below 35%;

[0036] (2) Weigh 200mg of tartaric acid, 300mg of sodium bicarbonate, 5mg of aspartame, 20mg of sodium chloride, and 200mg of mannitol, respectively pass through a 60-100 mesh sieve, add them into a three-dimensional mixer, and stir for 15-60 minutes;

[0037] (3) Precisely weigh 10-30mg of tetracaine hydrochloride, add it to the above mixed material by equal increment method, stir for 10-30 minutes, make the material fully mixed...

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PUM

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Abstract

The invention discloses a tetracaine hydrochloride oral effervescent tablet. The tetracaine hydrochloride oral effervescent tablet is prepared from the following components including tetracaine hydrochloride, tartaric acid, sodium bicarbonate, aspartame, sodium chloride, mannitol, an adhesive and a lubricant. A preparation method of the tetracaine hydrochloride oral effervescent tablet comprises the following steps: respectively sieving the tartaric acid, the sodium bicarbonate, the mannitol, the aspartame and the sodium chloride, adding into a mixer together, stirring, then adding the tetracaine hydrochloride into the mixture, fully stirring, then adding a PVP absolute ethyl alcohol solution, fully stirring to prepare a soft material, sieving the soft material, drying, carrying out size stabilization, adding PEG6000, fully stirring, and tabletting to obtain the tetracaine hydrochloride oral effervescent tablet. The tetracaine hydrochloride oral effervescent tablet has the remarkable effects that after the tablet is put into an oral cavity, a great amount of bubbles are immediately generated under the action of an effervescent disintegrating agent to enable the tablet to be rapidly disintegrated and melted, and the tetracaine hydrochloride is widely and directly contacted with the oral cavity part, so that the local anesthetic action is better exerted, the comfort degree of a patient in the awake intubation process is increased, and pains of the patient are reduced to the maximum.

Description

[0001] technical field [0002] The invention belongs to anesthetics in the field of medicine, in particular to an anesthetic tablet containing an effervescent disintegrant and a preparation method thereof. [0003] Background technique [0004] In clinical anesthesia, tracheal intubation to control breathing in patients under general anesthesia is one of the essential measures to manage the airway. However, for patients with difficult airway, after induction of general anesthesia, the glottis cannot be exposed, or the endotracheal tube cannot be inserted into the glottis after blind exploration, which will seriously threaten the patient's life safety. In mild cases, the operation was canceled, and in severe cases, hypoxia CO 2 Accumulation, cardiac arrest. Therefore, clinical anesthesiologists usually choose awake tracheal intubation for such patients with difficult tracheal intubation. Endotracheal intubation in the awake state is an extremely painful process for the p...

Claims

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Application Information

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IPC IPC(8): A61K9/46A61K31/245A61P23/00
Inventor 赵博高文蔚夏中元
Owner WUHAN UNIV
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