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Traditional Chinese medicine extraction process online analysis sample preprocessing apparatus

A technology for sample pretreatment and extraction process, which is applied in the field of sample pretreatment devices for on-line analysis of Chinese medicine extraction process, can solve the problems of clogging of sampling pipes and flow cells, difficulty in collecting sample spectra, complex components, etc., to achieve safety guarantee and avoid interference , The effect of removing impurity particles

Inactive Publication Date: 2015-03-11
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the Chinese herbal medicine extract has complex components and many impurities, which are easy to contaminate or even block the sampling pipeline and flow cell. Once the flow cell is polluted, it is difficult for the near-infrared spectrometer to collect usable sample spectra.

Method used

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  • Traditional Chinese medicine extraction process online analysis sample preprocessing apparatus
  • Traditional Chinese medicine extraction process online analysis sample preprocessing apparatus
  • Traditional Chinese medicine extraction process online analysis sample preprocessing apparatus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] see figure 1 , the online analysis of traditional Chinese medicine sample pretreatment device of the present invention consists of a first filter element 1 (80 μm), a booster pump 2, a first pneumatic valve 3, a second pneumatic valve 4, a third pneumatic valve 5, a fourth pneumatic valve 6, (50 μm ) second filter element 7, (50μm) third filter element 8, fifth pneumatic valve 9, sixth pneumatic valve 10, seventh pneumatic valve 11, eighth pneumatic valve 12, flow cell 13, optical fiber 14, sampling valve 15, reverse A water inlet 16, a waste liquid outlet 17 and a sampling port 18 are formed. The first filter element 1 is connected to the booster pump 2, the other end of the booster pump 2 is connected to the first pneumatic valve 3 and the third pneumatic valve 5, the other end of the first pneumatic valve 3 is connected to the second pneumatic valve 4, and the third pneumatic valve 5 is connected to the fourth pneumatic valve 6, the second filter element 7 is connec...

Embodiment 2

[0026] Example 2 On-line detection of water extraction process of Astragalus membranaceus

[0027] This example takes the extraction process of Radix Astragali as the object, by adopting the present invention to filter the feed liquid in the extraction process, utilizing the near-infrared spectrometer to collect the online spectrum of the extraction process, and establishing the concentration of four kinds of saponins and their summation value (Astragalus membranaceus total saponins) and the near-infrared spectrum, and the quantitative analysis model of total saponins of astragalus is used in the online monitoring of the extraction process of astragalus, which instantly reflects the dissolution information of total saponins in the extraction process of astragalus, and is the terminal judgment of the extraction process of astragalus And provide a reference for process optimization.

[0028] In this example, the extraction process of Astragalus lasts for 120 minutes. During th...

Embodiment 3

[0038] Example 3 On-line detection of Codonopsis pilosula, red ginseng, rehmannia glutinosa and hawthorn medicinal materials mixed water extraction process

[0039] Taking the mixed extraction process of Codonopsis ginseng, red ginseng, Rehmannia glutinosa and hawthorn as the object, by adopting the present invention to filter the material liquid in the extraction process, and using the near infrared spectrometer to collect the online spectrum of the extraction process, the near infrared spectrum of the extraction liquid is established. The quantitative calibration model between the spectrum and the content of important quality control indicators such as total flavonoids, total saponins, and total sugars realizes rapid quantitative analysis of the extract.

[0040] The samples used in this example are directly collected from the extraction workshop of a certain company, and are the extract samples obtained at different time points during the actual extraction process. The st...

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Abstract

The invention provides a traditional Chinese medicine extraction process online analysis sample preprocessing apparatus with automatic filtering and cleaning functions. The apparatus is formed by a pressurizing water pump, an automatic transfer valve, a filter, an automatic flushing device and an online detection and analysis device. The double channel filter is connected with the pipeline of the automatic flushing device through the transfer valve, and a system automatically flushes by selecting the on-off of the transfer valve and setting the operation period. The system adopts a central controller to carry out parameter set and automatic control. The apparatus is reasonably designed, can effectively remove impurity particles in a soup, ensures that a sample enters an online detection analyzer at a required temperature under a constant flow velocity, and is suitable for online analysis and monitoring of the production of a traditional Chinese medicinal soup from a traditional Chinese medicine.

Description

technical field [0001] The invention belongs to the field of extraction of traditional Chinese medicines, and relates to a pretreatment device for online analysis of samples in the extraction process of traditional Chinese medicines. Background technique [0002] Spectroscopy is an important process analysis technology. In order to implement process analysis technology in traditional Chinese medicine production enterprises, it is necessary to develop an online spectrum acquisition method. Taking the extraction process of Chinese medicinal materials as an example, in order to ensure the stability of the process, it is necessary to develop an online analysis method that can monitor the status of the sample in real time. Near-infrared spectroscopy has become the first choice for the analysis method due to its advantages of fast, accurate, and non-destructive samples. There are many modes of near-infrared spectroscopy applied to process analysis, including in line, on line, at l...

Claims

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Application Information

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IPC IPC(8): G01N1/34G01N21/3577G01N21/359
Inventor 瞿海斌李文龙程翼宇
Owner ZHEJIANG UNIV
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