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A pharmaceutical composition containing amlodipine and its application in the preparation of anti-stroke drugs

A technology of levoamlodipine and its composition, which is applied in the field of cerebrovascular drugs, can solve the problem of no golden eriodictine anti-stroke, and achieve the effects of reduced adverse reaction rate, reduced side effects, and low toxicity

Inactive Publication Date: 2017-01-18
THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no literature report on the anti-stroke effect of golden eriodictine, and there is no literature report on anti-stroke after it is combined with calcium channel blockers.

Method used

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  • A pharmaceutical composition containing amlodipine and its application in the preparation of anti-stroke drugs
  • A pharmaceutical composition containing amlodipine and its application in the preparation of anti-stroke drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 40 healthy male clean-grade Wistar rats, body weight 250-300g. The rats were randomly divided into the following five groups: normal control group, model control group, golden eriodictine group, amlodipine group, and golden eriodactyl-ammonium chloride group, with 8 rats in each group. After the test started, each group was intragastrically given the corresponding test substance in the following doses:

[0021] Normal control group: 0.5% sodium carboxymethylcellulose solution at 10mL / kg;

[0022] Model control group: 0.5% sodium carboxymethylcellulose solution at 10mL / kg;

[0023] Aureotin group: 90mg / kg aureotin (dissolve aureotin in 0.5% sodium carboxymethylcellulose solution);

[0024] Amlodipine group: 1 mg / kg of levamlodipine (dissolve levamlodipine besylate in 0.5% sodium carboxymethylcellulose solution);

[0025] Jinsheng-amlodipine group: 45mg / kg of golden eriodictyrin and 0.5mg / kg of levamlodipine (dissolve levamlodipine besylate and golden eriodictine in 0....

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Abstract

The invention discloses an anti-stroke pharmaceutical composition and application thereof, and belongs to the technical field of medicines. The pharmaceutical composition comprises active compositions and pharmaceutically-acceptable auxiliary materials, and the active compositions comprise the following components: (1) racemic amlodipine and levogyrate amlodipine or pharmaceutically-acceptable salts; and (2) chrysoeriol. Chrysoeriol combined with amlodipine has the effect of synergically resisting brain stroke, and the pharmaceutical composition prepared from chrysoeriol and amlodipine is applicable to prevent brain tissue from being damaged after brain stroke happens.

Description

technical field [0001] The invention relates to a cerebrovascular drug, in particular to a pharmaceutical composition containing amlodipine and its application in the preparation of anti-stroke drugs, belonging to the technical field of medicine. Background technique [0002] Stroke, also known as cerebral apoplexy or cerebrovascular accident, is a disease of the central nervous system caused by narrowing, occlusion or rupture of intracerebral arteries due to various causes, which in turn causes acute cerebral blood circulation disturbance. Because of its high morbidity, high disability, and high mortality, stroke has become a major disease that threatens human health and affects the quality of life, bringing heavy burdens to society and families. In European and American countries, stroke has always been the third cause of death and the first cause of disability. The latest epidemiological data show that in the United States, about 8 million people suffer from stroke every...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4422A61P9/10A61K31/352
CPCA61K31/352A61K31/4422A61K2300/00
Inventor 田小军苏洲郭双喜杜佳刘丽
Owner THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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