Application of tauroursodeoxycholic acid salt used as active ingredient in preparation of drug for treating echinococcosis

Abstract

The invention discloses application of tauroursodeoxycholic acid salt used as an active ingredient in preparation of a drug for treating echinococcosis. The tauroursodeoxycholic acid salt is used as the active ingredient for killing pathogen-echinococcus granulosus of the echinococcosis; an obvious echinococcosis protoscolex restraining and killing effect is achieved, and thus, the treatment of the echinococcosis is realized.

Description

technical field [0001] The invention relates to the pharmaceutical effect and biological effect of tauroursodeoxycholate, belonging to the field of medicinal chemistry. Background technique [0002] Echinococcus granulosus (Echinococcus granulosus, Eg), also known as cystic echinococcosis (CE), is caused by the middle-stage larvae of Echinococcus granulosus (Eg) Zoonotic parasitic diseases for health and livestock development. The disease is distributed globally and is mainly prevalent in Xinjiang, Qinghai, Inner Mongolia, Tibet and other provinces with developed animal husbandry in my country. Cystic echinococcosis primarily affects the liver, but can also develop in the lungs. At present, the treatment for this disease is mainly a surgical method, that is, complete resection of the outer and outer capsules of the hepatic hydatid adventitia. Although the complete excision of the outer and outer capsules of the hepatic hydatid cysts adopted in recent years can greatly red...

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Problems solved by technology

Therefore, on the whole, extravasation of the scoliosis and improper handling of the scoliosis during surgery are insurmountable defects in the surgical treatment of cystic echinococcosis.

[0003] For the problems referred to above, this area tries to adopt high-concentration acidic (HCl) and alkaline solution (KOH) in vitro, and the local chemotherapeutic drug commonly used in clinic has 20% hypertonic saline, but has certain destructive effect to surrounding normal liver tissue; Studies in the field have also found that bile can inhibit the development of hydatid cysts, but bile has complex components, multiple targets, and variable pharmacological effects. For example, the retention of bile and bile acids in the liver and blood will produce a variety of toxic effects, including cytotoxicity. The effects of acute and chronic toxicity can cause liver damage and damage to multiple systems and organs throughout the body, and eventually lead to liver cirrhosis, liver failure and death; studies have also found that bile acids can damage pancreatic acinar cells, etc.

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