Preparation method of composite particle of polymer embedded hydrophilic antitumor drug

Abstract

The invention specifically relates to a preparation method of a polymer drug carrier-loaded drug, and in particular relates to a composite particle of a polymer embedded hydrophilic antitumor drug prepared through in-situ dispersion polymerization, belonging to the cross technical field chemical engineering, pharmaceutical engineering and material engineering. The hydrophilic antitumor drug is embedded through an in-situ dispersion polymerization technology; a mixed solution of ethanol and de-ionized water serves as a dispersion medium; a monomer, the hydrophilic antitumor drug, an initiator and a dispersant are dissolved in the mixed solution to form a homogeneous solution; and a dispersion polymerization reaction is conducted to obtain the composite particle of the mono-disperse polymer embedded hydrophilic antitumor drug in micrometer size. The method disclosed by the invention, which embeds the drug in the polymer particle through one-step dispersion polymerization, is simple in preparation, and drug molecules are uniformly distributed in the polymer particle; the polymer particle is in micro-sized mono-dispersion; drug loading capacity and encapsulation efficiency of the drug are relatively high; and the preparation method has a broad application prospect in aspect of pharmaceutical preparations.

Description

technical field [0001] The present invention specifically relates to a preparation method of polymer drug carrier drug loading, in particular to the preparation of composite particles of polymer-embedded hydrophilic anti-tumor drugs by using in-situ dispersion polymerization method, which belongs to the interdisciplinary technology of chemical engineering, pharmaceutical engineering and material engineering field. Background technique [0002] The side effects of anti-tumor drugs are large. While killing tumor cells, they will cause damage to normal tissue cells in the body, reduce human immunity, and are not conducive to the recovery of tumor patients. Therefore, it is necessary to select a suitable drug carrier for anti-tumor drugs to package Buried, to eliminate or reduce the harm to the human body. [0003] Polymer materials with excellent biocompatibility are widely used in drug carriers. They not only have good processability, but also can regulate the release of drug...

AI Technical Summary

Problems solved by technology

[0005] Composite microspheres or microcapsules embedded with hydrophilic anti-tumor drugs obtained by the above method are complex and cumbersome to operate, the drug loading and coating rate are low, the drug and the polymer drug carrier are physically mixed, and the molecular distribution of the drug is relatively low. Inhomogeneity, prone to agglomeration, poor drug stability, thus affecting the therapeutic effect

In addition, the use of organic solvents in the embedding process is likely to cause secondary damage to the human body and cause environmental pollution