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Drug for treating and/or preventing tumor

A tumor and drug technology, applied in the field of biomedicine, can solve problems affecting the efficacy of drugs, unfavorable recovery, and increased frequency of drug interactions

Inactive Publication Date: 2015-02-04
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because chemotherapy or radiotherapy kills cancer cells, normal cells will also be damaged to varying degrees, which will cause greater side effects, reduce the quality of life of patients, and is not conducive to recovery
Although cancer treatment technology is constantly improving, low-toxicity, effective and inclusive treatment options are still relatively rare. Currently, multi-drug combination therapy is a treatment trend for cancer treatment
However, due to the large variety of drugs used in multi-drug combination, the frequency of drug interactions increases, which not only affects the efficacy of drugs, but also increases the toxicity of drugs, resulting in serious side effects and endangering the life safety of patients.

Method used

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  • Drug for treating and/or preventing tumor
  • Drug for treating and/or preventing tumor
  • Drug for treating and/or preventing tumor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1. The ability of the composition composed of sodium ascorbate and disulfiram to selectively inhibit the growth of tumor cells in vitro

[0034] 1. The synergistic effect of sodium ascorbate and disulfiram in tumor treatment

[0035] 1. Cell imaging experiments

[0036] 1) Cell culture: HCC-9204 cells in the logarithmic growth phase were digested with 0.05% trypsin and resuspended cells were collected in RMPI 1640 medium containing 10% FBS, and inoculated into 10 cm culture dishes (the volume of the cell solution was 10 mL, and the cells were Density is 2×10 4 / mL), a total of 4 dishes were inoculated, placed at 37 ° C, 5% CO 2 Cultured in a constant temperature incubator for 24 hours.

[0037] 2) Drug preparation: Sodium ascorbate was prepared into a 100 mM stock solution with PBS buffer solution, and disulfiram was prepared with DMSO into a 100 mM stock solution. Use RMPI 1640 medium to dilute 100mM sodium ascorbate stock solution into 1mM sodium ascorbate...

Embodiment 2

[0067] Example 2. The ability of the composition composed of sodium ascorbate and disulfiram to selectively inhibit the growth of tumor cells in vivo

[0068] Dissolve 0.6g of sodium ascorbate in 2mL of PBS buffer solution to form a sodium ascorbate solution with a concentration of 0.3g / mL; dissolve 6mg of disulfiram in 500μL of DMSO solution and add 1.5mL of PBS buffer solution to dilute to form a concentration of 3mg / mL disulfiram solution; Dissolve 1.2g sodium ascorbate in 2mL PBS buffer solution to make a sodium ascorbate solution with a concentration of 0.6g / mL; Dissolve 12mg disulfiram in 500μL DMSO solution and add 1.5mL Dilute with PBS buffer solution and configure disulfiram solution with a concentration of 6mg / mL. Mix 1 mL of sodium ascorbate solution with a concentration of 0.6 g / mL and 1 mL of disulfiram solution with a concentration of 6 mg / mL to prepare sodium ascorbate and disulfiram solution. Disulfiram composition solution, in this sodium ascorbate and disulfi...

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Abstract

The invention discloses a drug for treating and / or preventing tumor. The drug comprises active components, namely a component A and a component B, wherein the component A is ascorbic acid soluble salt or ascorbic acid, and the component B is disulfiram. The compound drug which comprises sodium ascorbate and the disulfiram can effectively inhibit the growth of in-vivo in-vitro cancer cells, achieves the synergistic effect, achieves the selective killing effect on tumor cells and can be used as a low-toxicity effective compound drug for treating and / or preventing the tumor.

Description

technical field [0001] The invention relates to a drug for treating and / or preventing tumors in the field of biomedicine. Background technique [0002] Malignant tumors (also known as cancers) are diseases caused by abnormal mechanisms controlling cell growth and proliferation. In addition to growing uncontrollably, cancer cells can also partially invade surrounding normal tissues and even transfer to other parts of the body through the circulatory system in the body. Cancer has become one of the main causes of death worldwide and seriously threatens human health. Liver cancer is a malignant tumor of the liver. It is a common and frequently-occurring disease in surgical diseases. Liver cancer can be divided into two categories: primary and secondary. Primary malignant tumors of the liver originate from the epithelial or mesenchymal tissues of the liver. The former is called primary liver cancer, which is a malignant tumor with a high incidence in my country and is extremely...

Claims

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Application Information

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IPC IPC(8): A61K31/375A61P35/00A61K31/145
CPCA61K31/145A61K31/375A61K2300/00
Inventor 林坚黄裕兵田永路钟武
Owner PEKING UNIV
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