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Application of saussurea involucrate culture in preparing product capable of suppressing skin pigmentation

A technology of skin pigmentation and snow lotus culture, which is applied in the application field of products, can solve the problems that the freckle removal effect of snow lotus culture has not been found, and the freckle removal effect of snow lotus has not been mentioned.

Active Publication Date: 2015-01-28
DALIAN PRACTICAL BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Invention patent ZL201110415844.9 discloses a composition for whitening and beautifying women. The culture of snow lotus is one of the ingredients, but the patent only reveals that snow lotus has immune regulation, blood lipid regulation, anti-aging, anti-fatigue, hypoxia resistance, and anti-radiation and anti-inflammatory and analgesic effects
[0006] Invention patent ZL201210106883.5 discloses a freckle-removing composition and its preparation method, but also does not mention that snow lotus has freckle-removing effect
[0007] There is no report that the culture of snow lotus has the effect of removing freckles

Method used

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  • Application of saussurea involucrate culture in preparing product capable of suppressing skin pigmentation
  • Application of saussurea involucrate culture in preparing product capable of suppressing skin pigmentation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 Melanin removal experiment

[0025] The freckle removal ability of Saussurea edulis culture can be evaluated by measuring the inhibition rate of Saussurea edulis and Saussurea edulis culture on melanin synthesis of melanoma cells.

[0026] Human melanoma cells A375 were inoculated in a 24-well plate at a density of 2×104 / ml, and cultured in a 37-degree, 5% CO2 incubator. After 24 hours, the medium was changed, and culture medium containing different concentrations of snow lotus or snow lotus was added, 500 μl per well. The medium is RPMI1640 medium containing 10% calf serum, and 1 × 10 5 U / L of penicillin and 100mg / L of streptomycin. The medium was supplemented with 2 mM theophylline and 0.5% dimethyl sulfoxide. After culturing for 72 hours, wash the cells with phosphate buffer, add 150 μl of 1M sodium hydroxide solution, and boil for 5 minutes to lyse the cells and dissolve the melanin. The lysate was transferred to a 96-well plate, 100 μl per well, an...

Embodiment 2

[0030] 1. Formula and preparation method of snow lotus or snow lotus culture capsule

[0031] ⑴Materials: 100g of snow lotus or snow lotus culture;

[0032] Excipients: maltodextrin 94g, silicon dioxide 6g;

[0033] Make 1000 capsules, each capsule is 0.20g.

[0034] (2) Sieving: pass the culture of snow lotus and maltodextrin through a 80-mesh sieve, and silicon dioxide through a 100-mesh sieve, and set aside;

[0035] (3) Mixing: first mix the snow lotus culture and maltodextrin to obtain mixed powder A, then mix mixed powder A and silicon dioxide in an equal increment method to obtain mixed powder, pass the mixed powder through a 60-mesh sieve, and then Mix in a plastic bag for another 20 minutes to obtain a total mixed powder.

[0036] ⑷Capsule filling and polishing.

[0037] 2. Observation of clinical efficacy in the treatment of chloasma

[0038] 100 patients were treated, including 38 males and 62 females, ranging in age from 20 to 55 years old; the course of disea...

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Abstract

The invention discloses application of a saussurea involucrate culture in preparing a product capable of suppressing skin pigmentation. The suppression of the skin pigmentation is to beautify the skin, whiten freckles or remove the freckles; the product is food, a medicine or a whitening cosmetic. A cell test and a clinical test prove that the saussurea involucrate culture can suppress the skin pigmentation and achieve the effects of beautifying the skin, whitening the freckles and removing the freckles, so that the saussurea involucrate culture can be used for preparing the food, the medicine or the cosmetic for beautifying the skin, whitening freckles or removing the freckles.

Description

technical field [0001] The invention relates to the application of snow lotus culture, in particular to the application of snow lotus culture in preparing products for inhibiting skin pigmentation. Background technique [0002] Human skin contains a variety of pigments, such as yellow pigment, brown pigment and melanin, and these pigments are generally referred to as "melanin". The color of the skin is affected by many factors, among which the distribution of melanin in the dermis of the skin plays a decisive role in the color of the skin, and the excessive deposition of melanin in the skin, that is, the abnormal hyperplasia of melanin, is the main cause of skin spots. Reduce local skin pigmentation, can achieve whitening, freckle or blemish effect. [0003] Chloasma, freckles, and sunburn are common types of skin pigmentation, all of which are closely related to pigmentation. Chloasma, also known as butterfly spots, pregnancy spots, liver spots, dark spots, etc., is simil...

Claims

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Application Information

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IPC IPC(8): A61K36/285A61K8/97A23L1/29A61Q19/02A61P17/00A23L33/00
CPCA23V2002/00A61K8/97A61K9/4866A61K36/285A61Q19/00A61Q19/02A23V2200/318
Inventor 刘汉石范文霞张献刘雅萍陈晓霞
Owner DALIAN PRACTICAL BIOTECH
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