Floating and sustained-release pellet, pharmaceutical composition containing pellet and preparation method of pharmaceutical composition
A technology of sustained-release pellets and compositions, which is applied in the direction of drug combinations, medical preparations containing active ingredients, and medical preparations with non-active ingredients, etc. Controlled release effect and other issues, to achieve the effect of maintaining stability and prolonging the continuous floating time
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Embodiment 1
[0106] An embodiment of the floating slow-release pellets of the present invention, the structure of the floating slow-release pellets described in this embodiment is as attached figure 1 shown by the attached figure 1 It can be seen that the floating sustained-release pellets described in this embodiment are sequentially composed of a pill core 1, a bleaching aid layer 2, a sustained-release coating layer 3 and a protective layer 4 from inside to outside, and the floating sustained-release pellets described in this embodiment contain Components of the following masses:
[0107]
[0108] The floating sustained-release pellets described in this example are prepared by the following method:
[0109] (1) Preparation of pill cores: sieve pregabalin, fillers, blockers and binders, and then mix them uniformly in a three-dimensional mixer to obtain premixed powder; put the premixed powder in extrusion- In the spheronizer, add a wetting agent to obtain a 200-350 μm drug-containin...
Embodiment 2
[0115] An embodiment of the floating slow-release pellets of the present invention, the structure of the floating slow-release pellets described in this embodiment is the same as in Example 1; in the preparation method of the floating slow-release pellets, the diluent used in step (3) is purified water , other preparation processes are all the same as in Example 1. The floating sustained-release pellets described in this embodiment contain the following components:
[0116]
Embodiment 3
[0118] An embodiment of the floating slow-release pellets of the present invention, the structure and preparation method of the floating slow-release pellets described in this example are the same as in Example 2, and the floating slow-release pellets described in this example contain the following components:
[0119]
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