Application of composition in preparation of medicine for treating obesity
A composition and obesity technology, applied in the field of medicine, can solve problems such as obesity associated diseases
Inactive Publication Date: 2015-01-14
WUXI XINDA MEDICAL DEVICE
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- Abstract
- Description
- Claims
- Application Information
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Problems solved by technology
[0013] In the prior art, most of the treatment of obesity only considers the obesity itself, but does not consider the accompanying diseases of obesity, such as hypertension, hyperlipidemia, diabetes, etc.
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0023] An application of a composition in the preparation of a medicament for treating obesity, characterized in that the composition comprises a therapeutically effective amount of 1-isopropyl-1'-(1-methyl-2-oxo-2, 3-dihydro-1H-benzo[d]imidazole-5-carbonyl)-4,6-dihydrospiro[indazole-5,4′-piperidin]-7(1H)-one, and a therapeutically effective amount 4-[5-cyano-4-({2-fluoro-4-[(2-hydroxyethyl)sulfonyl]phenoxy}methyl)-1H-pyrazol-1-yl]piperidine- 1-isopropyl formate; the mass ratio of the two is 1:1.
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Abstract
The invention discloses application of a composition in preparation of a medicine for treating obesity. The composition contains a therapeutically-effective amount of 1-isopropyl-1'-(1-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-carbonyl)-4,6-dihydrospiro[indazol-5,4'-piperidine]-7(1H)-one and a therapeutically-effective amount of 4-[5-cyano-4-({2-fluoro-4-[(2-hydroxyethyl)sulfonyl]phenoxy}methyl)-1H-pyrazol-1-yl]piperidin-1-isopropyl formate which have the mass ratio of (3: 1) to (1: 3). By using the two kinds of drugs in a combined manner, symptoms, such as hypertension and diabetes, caused by the obesity can be treated while the obesity is treated.
Description
technical field [0001] The invention relates to a medicine, in particular to the application of a composition in the preparation of a medicine for treating obesity. Background technique [0002] Obesity is a state of excessive accumulation of body fat, especially triglycerides (triacylglycerols). Usually due to excessive food intake or changes in body metabolism, excessive fat accumulation in the body results in excessive weight gain and pathophysiological changes in the human body. Body mass index (BMI) is the square of weight (Kg) divided by height (m), and is an indicator for assessing the degree of obesity. In Europe and America, BMI≥25kg / m 2 Overweight, BMI≥30kg / m 2 for obesity. People in the Asia-Pacific region can be divided according to their BMI: healthy 18.5-22.9kg / m 2 ;Overweight 23-24.9kg / m 2 ; Level 1 obesity 25-29.9kg / m 2 ;2 degree obesity 30-34.9kg / m 2 ; Grade 3 obesity > 35kg / m 2 . [0003] Obesity can cause high blood pressure (the incidence of ...
Claims
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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/454A61P3/04A61P9/12A61P3/10A61K31/438
CPCA61K31/454A61K31/438
Inventor 王岳荣
Owner WUXI XINDA MEDICAL DEVICE
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