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Medicinal composition of indapamide and folic acid and application of medicinal composition

A technology of indapamide and its composition, which is applied in the pharmaceutical composition of indapamide and folic acid and its application field, to achieve the effect of reducing plasma Hcy level, increasing plasma folic acid level, and alleviating damage

Inactive Publication Date: 2014-12-24
SHENZHEN AUSA PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the clinical benefit / risk ratio of long-term application of indapamide in hypertensive patients needs to be further improved

Method used

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  • Medicinal composition of indapamide and folic acid and application of medicinal composition
  • Medicinal composition of indapamide and folic acid and application of medicinal composition
  • Medicinal composition of indapamide and folic acid and application of medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Preparation of Indapamide / Folic Acid (1.25mg / 0.4mg) Tablets (1000 Tablets)

[0030] Recipe composition:

[0031]

[0032] Preparation Process:

[0033] Mix folic acid and indapamide in equal increments, add lactose, microcrystalline cellulose, and pregelatinized starch, mix evenly, use an appropriate amount of 10% povidone ethanol solution to make a soft material, granulate, dry, and granulate , mix the granules with a water content of about 3% and an appropriate amount of magnesium stearate evenly, and make 1000 tablets according to a conventional method.

Embodiment 2

[0034] Example 2: Preparation of Indapamide / Folic Acid (2.5mg / 0.8mg) Tablets (1000 Tablets)

[0035] Recipe composition:

[0036]

[0037] The preparation process is the same as in Example 1.

Embodiment 3

[0038] Embodiment 3: Preparation of indapamide / folic acid (2.5mg / 0.8mg) capsules (1000 capsules)

[0039] Recipe composition:

[0040]

[0041] Preparation Process:

[0042] According to the prescription ratio, take lactose, microcrystalline cellulose, and sodium starch glycolate and dry them at about 100°C for about 2 hours respectively. The sodium starch glycolate is passed through a 100-mesh sieve, and the lactose and microcrystalline cellulose are passed through a 80-mesh sieve; After passing through a 100-mesh sieve, it is uniformly mixed with the above-mentioned auxiliary material mixture, granulated, then mixed with an appropriate amount of glyceryl behenate, and filled with No. 3 capsules. Make 1000 capsules.

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PUM

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Abstract

The invention relates to a medicinal composition prepared from indapamide, folic acid and a medicinally available carrier, and application of the composition for preparing a drug for treating hypertension with hyperhomocysteinemia and a disease of homocysteine rising. In the composition, the preferable content of indapamide is 0.625-2.5 mg, and the preferable content of folic acid is 0.4-0.8 mg. The medicinal composition disclosed by the invention has the benefits that indapamide and folic acid can be combined to reduce blood pressure, obviously lower level of homocysteine and raise the level of folic acid, so as to relieve damage of homocysteine to the blood vessel, strengthen targeted organ protection for a hypertension patient, and play a pharmacologic synergistic role. In addition, the medicinal composition can further allow the patient to take medicine conveniently and reduce the medical costs.

Description

technical field [0001] The invention relates to a pharmaceutical composition composed of indapamide and folic acid and its application in the preparation of medicines for treating hypertension accompanied by hyperhomocysteinemia or elevated homocysteine. belongs to the field of pharmacy. Background technique [0002] Hypertension is one of the most common chronic diseases, and it is also the most important risk factor for cardiovascular and cerebrovascular diseases. High, serious consumption of medical resources, a heavy burden on the family and society. The main goal of hypertension treatment is to minimize the overall risk of cardiovascular complications and death, and it is necessary to treat all reversible cardiovascular risk factors, subclinical target organ damage, and various coexisting clinical diseases [Chinese Hypertension Prevention and Treatment]. Guidelines Revision Committee. Chinese Guidelines for the Prevention and Treatment of Hypertension 2010. Chinese Jo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61P9/12A61P3/00A61P7/00A61K31/404
Inventor 张磊王存芳徐希平
Owner SHENZHEN AUSA PHARMA
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